MSD
Overview
The Quantitative Pharmacology and Pharmacometrics (QP2) department drives model-informed drug discovery and development (MIDD) to enable efficient drug discovery, development, and regulatory decisions. The Pharmacometrics group provides leadership, modeling expertise, and innovative tools to drive portfolio impact from discovery through life-cycle management. With MIDD as an essential component of decision-making at our company, this position offers an opportunity for the Pharmacometrics leader to influence pipeline strategy and lead a team of pharmacometricians. Responsibilities
Guide a team of approximately 5-6 pharmacometricians to achieve program goals by identifying and implementing novel quantitative approaches (e.g., comparator modeling, clinical trial simulations, quantitative systems pharmacology, disease progression models, artificial intelligence algorithms, and machine learning methods) to improve cycle time, cost/size of trials, and the number of trials; implement tools and regulatory frameworks to enable rapid approvals and drive Go/No-Go decisions.
Foster collaboration within QP2 to achieve results and remove barriers across portfolio or scientific priorities.
Initiate and manage external collaborations to develop new methodologies and lead external outreach to the scientific pharmacometrics community.
Evaluate and maintain appropriate quality systems and IT infrastructure to support emerging capabilities.
Responsible for priority-setting, performance management, hiring and retention, and talent development/management for direct reports.
Required Experience
A Ph.D. or equivalent degree with 7+ years of experience OR a PharmD or equivalent degree with 9+ years of experience OR an MS or equivalent degree with 11+ years of experience, where experience means increasing responsibility and independence in a similar role in pharmaceutical drug development or academia.
Educational background in pharmacometrics, pharmaceutical sciences, mathematics, statistics/biostatistics, computational biology/chemistry, chemical/biomedical engineering, or a related field.
Deep expertise in pharmacometrics (e.g., population PK/PKPD analyses, model-based meta-analysis, dose–response and exposure–response analyses, disease modeling, trial simulation, optimal study designs, strategic decision analyses, economic modeling, and AI/ML methods) with ability to link MIDD to portfolio and regulatory decisions.
Deep knowledge of drug development, pharmacokinetics and pharmacology, and basic science skills.
Preferred Experience
Extensive experience in developing quantitative strategies to impact pipeline decisions.
Drug development and regulatory experience across therapeutic areas, with a track record of PMx impact in driving model-informed drug development strategies across programs.
Strong interpersonal and communication skills for productive teamwork among diverse audiences.
Current employees apply for this role here. Current contingent workers apply for this role here. Additional Information
US and Puerto Rico Residents Only:
We are committed to inclusion and provide accommodations during the hiring process upon request. Equal Employment Opportunity:
We provide equal opportunities to all employees and applicants and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other legally protected characteristics. As a federal contractor, we comply with affirmative action requirements for protected veterans and individuals with disabilities. For more information about rights under U.S. EEO laws, visit the EEOC Know Your Rights and EEOC GINA Supplement pages. Hybrid Work Model (U.S.)
Effective September 5, 2023, employees in office-based positions in the U.S. will follow a Hybrid model with three on-site days per week and one remote day, subject to site-specific requirements. Some roles require in-person attendance or are remote per business needs. Salary
The salary range for this role is $206,200.00 - $324,600.00. Compensation is based on education, qualifications, experience, location, and business needs. Benefits
We offer a comprehensive benefits package including medical, dental, vision, retirement (401(k)), paid holidays, vacation, and sick leave. More information is available on the company compensation and benefits page. Application
You can apply through the company careers site. The application deadline is stated in the posting.
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The Quantitative Pharmacology and Pharmacometrics (QP2) department drives model-informed drug discovery and development (MIDD) to enable efficient drug discovery, development, and regulatory decisions. The Pharmacometrics group provides leadership, modeling expertise, and innovative tools to drive portfolio impact from discovery through life-cycle management. With MIDD as an essential component of decision-making at our company, this position offers an opportunity for the Pharmacometrics leader to influence pipeline strategy and lead a team of pharmacometricians. Responsibilities
Guide a team of approximately 5-6 pharmacometricians to achieve program goals by identifying and implementing novel quantitative approaches (e.g., comparator modeling, clinical trial simulations, quantitative systems pharmacology, disease progression models, artificial intelligence algorithms, and machine learning methods) to improve cycle time, cost/size of trials, and the number of trials; implement tools and regulatory frameworks to enable rapid approvals and drive Go/No-Go decisions.
Foster collaboration within QP2 to achieve results and remove barriers across portfolio or scientific priorities.
Initiate and manage external collaborations to develop new methodologies and lead external outreach to the scientific pharmacometrics community.
Evaluate and maintain appropriate quality systems and IT infrastructure to support emerging capabilities.
Responsible for priority-setting, performance management, hiring and retention, and talent development/management for direct reports.
Required Experience
A Ph.D. or equivalent degree with 7+ years of experience OR a PharmD or equivalent degree with 9+ years of experience OR an MS or equivalent degree with 11+ years of experience, where experience means increasing responsibility and independence in a similar role in pharmaceutical drug development or academia.
Educational background in pharmacometrics, pharmaceutical sciences, mathematics, statistics/biostatistics, computational biology/chemistry, chemical/biomedical engineering, or a related field.
Deep expertise in pharmacometrics (e.g., population PK/PKPD analyses, model-based meta-analysis, dose–response and exposure–response analyses, disease modeling, trial simulation, optimal study designs, strategic decision analyses, economic modeling, and AI/ML methods) with ability to link MIDD to portfolio and regulatory decisions.
Deep knowledge of drug development, pharmacokinetics and pharmacology, and basic science skills.
Preferred Experience
Extensive experience in developing quantitative strategies to impact pipeline decisions.
Drug development and regulatory experience across therapeutic areas, with a track record of PMx impact in driving model-informed drug development strategies across programs.
Strong interpersonal and communication skills for productive teamwork among diverse audiences.
Current employees apply for this role here. Current contingent workers apply for this role here. Additional Information
US and Puerto Rico Residents Only:
We are committed to inclusion and provide accommodations during the hiring process upon request. Equal Employment Opportunity:
We provide equal opportunities to all employees and applicants and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other legally protected characteristics. As a federal contractor, we comply with affirmative action requirements for protected veterans and individuals with disabilities. For more information about rights under U.S. EEO laws, visit the EEOC Know Your Rights and EEOC GINA Supplement pages. Hybrid Work Model (U.S.)
Effective September 5, 2023, employees in office-based positions in the U.S. will follow a Hybrid model with three on-site days per week and one remote day, subject to site-specific requirements. Some roles require in-person attendance or are remote per business needs. Salary
The salary range for this role is $206,200.00 - $324,600.00. Compensation is based on education, qualifications, experience, location, and business needs. Benefits
We offer a comprehensive benefits package including medical, dental, vision, retirement (401(k)), paid holidays, vacation, and sick leave. More information is available on the company compensation and benefits page. Application
You can apply through the company careers site. The application deadline is stated in the posting.
#J-18808-Ljbffr