MSD
Overview
The Quantitative Pharmacology and Pharmacometrics (QP2) department drives model-informed drug discovery and development (MIDD) to enable efficient drug discovery/development and regulatory decisions. The Pharmacometrics group within QP2 brings leadership, deep modeling expertise and state-of-the-art modeling approaches across multiple therapeutic areas and modalities to drive portfolio impact from discovery through life-cycle management. The team is externally visible and at the leading edge of building innovative tools. With MIDD as an essential component of decision-making at our company, this position offers an opportunity for the Pharmacometrics leader to drive pipeline impact and lead a talented group of pharmacometricians. This director will be part of a leadership team responsible for applying traditional and state-of-the-art pharmacometric approaches on the portfolio and continue to innovate pharmacometrics capabilities on a continuous basis. The Director will direct a team of pharmacometricians with diverse backgrounds and bring subject matter expertise related to model-informed drug discovery and development for programs. Responsibilities
Guide a team of approximately 5-6 pharmacometricians to achieve results on major program drivers by identifying and implementing novel quantitative approaches (for example: comparator modeling, clinical trial simulations, quantitative systems pharmacology (QSP) and disease progression models, artificial intelligence algorithms, machine learning methods) that seek to improve cycle time, cost/size and number of trials; implement tools and regulatory framework for rapid approvals and drive Go/No Go decisions on programs.
Foster collaboration within QP2 to achieve results and remove barriers on portfolio or scientific priorities.
Initiate and manage external collaborations to develop new methodologies and lead external outreach to the scientific pharmacometrics community.
Evaluate and maintain appropriate quality systems and IT infrastructure for QP2 to support emerging capabilities.
Responsible for priority-setting, performance management, hiring and retention, and talent development/management for direct reports.
Required Experience
A Ph.D. or equivalent degree with 7+ years of experience, or a PharmD or equivalent degree with 9+ years of experience, or an MS or equivalent degree with 11+ years of experience, where experience means a record of increasing responsibility and independence in a similar role in pharmaceutical drug development or academia.
Educational background in pharmacometrics, pharmaceutical sciences, mathematics, statistics/biostatistics, computational biology/chemistry, chemical/biomedical engineering, or a related field.
Deep expertise in pharmacometrics (e.g., population PK and PK/PD analyses, model-based meta-analysis, dose–response and exposure–response analyses, disease modeling, trial simulation, optimal study designs, strategic decision analyses, economic modeling, artificial intelligence algorithms, machine learning methods) with ability to understand how MIDD can drive portfolio and regulatory decisions.
Deep knowledge of drug development, pharmacokinetics and pharmacology and basic science skills required.
Preferred Experience
Extensive experience in developing quantitative strategies for impacting pipeline decisions.
Drug development and regulatory experience agnostic of therapeutic area, including a record of PMx impact in driving model-informed drug development strategies across programs.
Good interpersonal and communication skills that ensure teamwork and productive interactions among diverse personalities/areas of expertise.
Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please indicate if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together talented and committed people with diverse experiences, perspectives, skills and backgrounds. We encourage colleagues to respectfully challenge one another’s thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US state acts. U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid schedule of three total days on-site per week (Monday – Thursday, with Friday remote, subject to site variations and business needs). This model does not apply to field-based, manufacturing, or research-based positions located at a company site, or roles designated remote. The salary range for this role is $206,200.00 - $324,600.00. This range represents the lowest to highest salary we in good faith believe we would pay for this role at the time of posting. An employee’s position within the range will be based on education, qualifications, certifications, experience, skills, location, and business needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits, including medical, dental, vision, retirement benefits (e.g., 401(k)), paid holidays, vacation, and sick days. More information about benefits is available at the compensation and benefits page. You can apply for this role through the company careers site (or via the Workday Jobs Hub if you are a current employee). The application deadline is stated in the posting. Residency and Accessibility
San Francisco Residents Only:
We will consider qualified applicants with arrest and conviction records in compliance with the San Francisco Fair Chance Ordinance. Los Angeles Residents Only:
We will consider all qualified applicants, including those with criminal histories, in a manner consistent with applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance. Search Firm Representatives
Merck & Co., Inc. does not accept unsolicited assistance from search firms for employment opportunities. All CVs/resumes submitted by search firms without a valid written search agreement will be deemed the property of the company. No fee will be paid where there is no pre-existing agreement. Where agency agreements are in place, introductions are position-specific. Please, no phone calls or emails. Employee Status:
Regular Relocation:
Domestic VISA Sponsorship:
Yes Travel Requirements:
10% Flexible Work Arrangements:
Hybrid Shift:
Not Indicated Valid Driving License:
No Hazardous Materials:
n/a Required Skills:
Clinical Trial Designs, Data Analysis, Data Modeling, Data Visualization, Disease Models, Dose-Response Analysis, Drug Development, Drug Discovery Process, In Vivo Disease Models, Leadership, Machine Learning, Modeling Software, Multiple Therapeutic Areas, Pharmaceutical Development, Pharmaceutical Sciences, Pharmacokinetics, Pharmacology, Pharmacometrics, PKPD Modeling, Population Pharmacokinetics, Portfolio Management, Regulatory Applications, Software Development, Stakeholder Relationship Management Preferred Skills: Job Posting End Date:
09/27/2025 *A job posting is effective until 11:59:59PM on the day before the listed end date. Please apply no later than the day before the posting end date.
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The Quantitative Pharmacology and Pharmacometrics (QP2) department drives model-informed drug discovery and development (MIDD) to enable efficient drug discovery/development and regulatory decisions. The Pharmacometrics group within QP2 brings leadership, deep modeling expertise and state-of-the-art modeling approaches across multiple therapeutic areas and modalities to drive portfolio impact from discovery through life-cycle management. The team is externally visible and at the leading edge of building innovative tools. With MIDD as an essential component of decision-making at our company, this position offers an opportunity for the Pharmacometrics leader to drive pipeline impact and lead a talented group of pharmacometricians. This director will be part of a leadership team responsible for applying traditional and state-of-the-art pharmacometric approaches on the portfolio and continue to innovate pharmacometrics capabilities on a continuous basis. The Director will direct a team of pharmacometricians with diverse backgrounds and bring subject matter expertise related to model-informed drug discovery and development for programs. Responsibilities
Guide a team of approximately 5-6 pharmacometricians to achieve results on major program drivers by identifying and implementing novel quantitative approaches (for example: comparator modeling, clinical trial simulations, quantitative systems pharmacology (QSP) and disease progression models, artificial intelligence algorithms, machine learning methods) that seek to improve cycle time, cost/size and number of trials; implement tools and regulatory framework for rapid approvals and drive Go/No Go decisions on programs.
Foster collaboration within QP2 to achieve results and remove barriers on portfolio or scientific priorities.
Initiate and manage external collaborations to develop new methodologies and lead external outreach to the scientific pharmacometrics community.
Evaluate and maintain appropriate quality systems and IT infrastructure for QP2 to support emerging capabilities.
Responsible for priority-setting, performance management, hiring and retention, and talent development/management for direct reports.
Required Experience
A Ph.D. or equivalent degree with 7+ years of experience, or a PharmD or equivalent degree with 9+ years of experience, or an MS or equivalent degree with 11+ years of experience, where experience means a record of increasing responsibility and independence in a similar role in pharmaceutical drug development or academia.
Educational background in pharmacometrics, pharmaceutical sciences, mathematics, statistics/biostatistics, computational biology/chemistry, chemical/biomedical engineering, or a related field.
Deep expertise in pharmacometrics (e.g., population PK and PK/PD analyses, model-based meta-analysis, dose–response and exposure–response analyses, disease modeling, trial simulation, optimal study designs, strategic decision analyses, economic modeling, artificial intelligence algorithms, machine learning methods) with ability to understand how MIDD can drive portfolio and regulatory decisions.
Deep knowledge of drug development, pharmacokinetics and pharmacology and basic science skills required.
Preferred Experience
Extensive experience in developing quantitative strategies for impacting pipeline decisions.
Drug development and regulatory experience agnostic of therapeutic area, including a record of PMx impact in driving model-informed drug development strategies across programs.
Good interpersonal and communication skills that ensure teamwork and productive interactions among diverse personalities/areas of expertise.
Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please indicate if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together talented and committed people with diverse experiences, perspectives, skills and backgrounds. We encourage colleagues to respectfully challenge one another’s thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US state acts. U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid schedule of three total days on-site per week (Monday – Thursday, with Friday remote, subject to site variations and business needs). This model does not apply to field-based, manufacturing, or research-based positions located at a company site, or roles designated remote. The salary range for this role is $206,200.00 - $324,600.00. This range represents the lowest to highest salary we in good faith believe we would pay for this role at the time of posting. An employee’s position within the range will be based on education, qualifications, certifications, experience, skills, location, and business needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits, including medical, dental, vision, retirement benefits (e.g., 401(k)), paid holidays, vacation, and sick days. More information about benefits is available at the compensation and benefits page. You can apply for this role through the company careers site (or via the Workday Jobs Hub if you are a current employee). The application deadline is stated in the posting. Residency and Accessibility
San Francisco Residents Only:
We will consider qualified applicants with arrest and conviction records in compliance with the San Francisco Fair Chance Ordinance. Los Angeles Residents Only:
We will consider all qualified applicants, including those with criminal histories, in a manner consistent with applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance. Search Firm Representatives
Merck & Co., Inc. does not accept unsolicited assistance from search firms for employment opportunities. All CVs/resumes submitted by search firms without a valid written search agreement will be deemed the property of the company. No fee will be paid where there is no pre-existing agreement. Where agency agreements are in place, introductions are position-specific. Please, no phone calls or emails. Employee Status:
Regular Relocation:
Domestic VISA Sponsorship:
Yes Travel Requirements:
10% Flexible Work Arrangements:
Hybrid Shift:
Not Indicated Valid Driving License:
No Hazardous Materials:
n/a Required Skills:
Clinical Trial Designs, Data Analysis, Data Modeling, Data Visualization, Disease Models, Dose-Response Analysis, Drug Development, Drug Discovery Process, In Vivo Disease Models, Leadership, Machine Learning, Modeling Software, Multiple Therapeutic Areas, Pharmaceutical Development, Pharmaceutical Sciences, Pharmacokinetics, Pharmacology, Pharmacometrics, PKPD Modeling, Population Pharmacokinetics, Portfolio Management, Regulatory Applications, Software Development, Stakeholder Relationship Management Preferred Skills: Job Posting End Date:
09/27/2025 *A job posting is effective until 11:59:59PM on the day before the listed end date. Please apply no later than the day before the posting end date.
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