Howard Hughes Medical Institute (HHMI)
Postdoctoral Scientist - O'Brown Lab
Howard Hughes Medical Institute (HHMI), New Brunswick, New Jersey, us, 08933
Overview
Join to apply for the
Postdoctoral Scientist - O'Brown Lab
role at
Howard Hughes Medical Institute (HHMI) . Primary Work Address: Rutgers University/CABM, Piscataway, NJ, 08854-5638. About the O’Brown Lab: The O’Brown Lab at Rutgers University is unraveling the intricate mechanisms that govern the
blood-brain barrier (BBB)
— a specialized vascular interface that protects the brain and regulates the flow of ions, nutrients, and immune cells. The lab studies how the BBB forms and functions during development, how its breakdown contributes to neurological diseases, and how these insights can inform future therapeutic applications. The work integrates molecular, developmental, and vascular biology. About the Role
We are seeking a highly motivated and independent
Postdoctoral Scientist
to join our in-person, cross-disciplinary team. The role focuses on understanding the developmental and cellular mechanisms that regulate BBB function using zebrafish and mouse models. Projects aim to define how vascular and surrounding neuronal and glial cells interact during development, how these interactions are disrupted in disease, and how those insights can guide translational research. The position involves designing and executing experiments, overseeing undergraduate researchers, and collaborating closely with Dr. O’Brown and other lab members in a fast-paced, discovery-driven environment. What You’ll Get
Close mentorship from Dr. O’Brown and the opportunity to mentor junior trainees. A focus on career development, with support for producing publications. Active guidance for both academic and industry career pathways, with BBB research relevant to both. Ongoing networking support, including conferences and collaboration opportunities. The opportunity to shape the direction of a growing, high-impact lab at the intersection of development and neurovascular biology. What You will do
Lead independent research projects focused on vascular biology and BBB development. Conduct experiments in zebrafish and mouse models, including microinjections, live imaging, and behavioral studies. Apply molecular biology techniques including PCR, cloning, and genotyping. Perform in vivo imaging and high-resolution microscopy to visualize vascular function and BBB dynamics. Analyze or support RNA sequencing experiments. Supervise undergraduate trainees and contribute to an open, collaborative lab culture. Document and present findings in internal meetings and scientific publications. What You Bring
A Ph.D. in Developmental Biology, Molecular Biosciences, or a related field (e.g., Genetics, Systems Biology). Prior experience with in vivo techniques, ideally in zebrafish (preferred) or mouse models. Hands-on skills in vascular biology, developmental imaging, and/or BBB research. Experience with RNA sequencing workflows, data interpretation, or collaboration with sequencing teams. Proficiency in molecular biology techniques such as cloning, PCR, and genotyping. A strong sense of independence, with the ability to manage and lead scientific projects autonomously. Physical Requirements
Remaining in a normal seated or standing position for extended periods; dexterity to manipulate objects; good communication skills; ability to see and hear within normal parameters; ability to move about the workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Reasonable accommodation is available for applicants with disabilities; requests will be evaluated on an individual basis. Compensation And Benefits
HHMI offers a total rewards approach including competitive pay, health benefits, retirement plans, time off, and wellness programs. Compensation range: $70,000.00 (minimum) – $80,500.00 (midpoint) – $91,000.00 (maximum). Pay type: Annual. HHMI considers education, experience, and other factors when determining offers. EEO Statement : HHMI is an Equal Opportunity Employer. We use E-Verify to confirm identity and employment eligibility of all new hires.
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Join to apply for the
Postdoctoral Scientist - O'Brown Lab
role at
Howard Hughes Medical Institute (HHMI) . Primary Work Address: Rutgers University/CABM, Piscataway, NJ, 08854-5638. About the O’Brown Lab: The O’Brown Lab at Rutgers University is unraveling the intricate mechanisms that govern the
blood-brain barrier (BBB)
— a specialized vascular interface that protects the brain and regulates the flow of ions, nutrients, and immune cells. The lab studies how the BBB forms and functions during development, how its breakdown contributes to neurological diseases, and how these insights can inform future therapeutic applications. The work integrates molecular, developmental, and vascular biology. About the Role
We are seeking a highly motivated and independent
Postdoctoral Scientist
to join our in-person, cross-disciplinary team. The role focuses on understanding the developmental and cellular mechanisms that regulate BBB function using zebrafish and mouse models. Projects aim to define how vascular and surrounding neuronal and glial cells interact during development, how these interactions are disrupted in disease, and how those insights can guide translational research. The position involves designing and executing experiments, overseeing undergraduate researchers, and collaborating closely with Dr. O’Brown and other lab members in a fast-paced, discovery-driven environment. What You’ll Get
Close mentorship from Dr. O’Brown and the opportunity to mentor junior trainees. A focus on career development, with support for producing publications. Active guidance for both academic and industry career pathways, with BBB research relevant to both. Ongoing networking support, including conferences and collaboration opportunities. The opportunity to shape the direction of a growing, high-impact lab at the intersection of development and neurovascular biology. What You will do
Lead independent research projects focused on vascular biology and BBB development. Conduct experiments in zebrafish and mouse models, including microinjections, live imaging, and behavioral studies. Apply molecular biology techniques including PCR, cloning, and genotyping. Perform in vivo imaging and high-resolution microscopy to visualize vascular function and BBB dynamics. Analyze or support RNA sequencing experiments. Supervise undergraduate trainees and contribute to an open, collaborative lab culture. Document and present findings in internal meetings and scientific publications. What You Bring
A Ph.D. in Developmental Biology, Molecular Biosciences, or a related field (e.g., Genetics, Systems Biology). Prior experience with in vivo techniques, ideally in zebrafish (preferred) or mouse models. Hands-on skills in vascular biology, developmental imaging, and/or BBB research. Experience with RNA sequencing workflows, data interpretation, or collaboration with sequencing teams. Proficiency in molecular biology techniques such as cloning, PCR, and genotyping. A strong sense of independence, with the ability to manage and lead scientific projects autonomously. Physical Requirements
Remaining in a normal seated or standing position for extended periods; dexterity to manipulate objects; good communication skills; ability to see and hear within normal parameters; ability to move about the workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Reasonable accommodation is available for applicants with disabilities; requests will be evaluated on an individual basis. Compensation And Benefits
HHMI offers a total rewards approach including competitive pay, health benefits, retirement plans, time off, and wellness programs. Compensation range: $70,000.00 (minimum) – $80,500.00 (midpoint) – $91,000.00 (maximum). Pay type: Annual. HHMI considers education, experience, and other factors when determining offers. EEO Statement : HHMI is an Equal Opportunity Employer. We use E-Verify to confirm identity and employment eligibility of all new hires.
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