Springer Lab at BCH
Special Postdoctoral Fellow in Cell Surface Receptors, Integrin Agonists, and Or
Springer Lab at BCH, Boston, Massachusetts, us, 02298
Join the Lab of Tim Springer
Tim Springer, a leader in integrin biology, invites aspiring scientists to join his lab to advance groundbreaking research at the intersection of integrin signaling, organoid development, and cell surface receptor mechanobiology. A central focus of this role will be designing and applying integrin agonists to drive the growth and maturation of organoids, with wide-reaching implications for regenerative medicine, stem cell biology, and therapeutic development. This role offers mentorship and unique opportunities to establish a strong scientific foundation for launching an independent research career.
About the Role: As a Special Postdoctoral Fellow, you will: Pursue cutting-edge research in areas such as:
Stem Cells and organoids: Develop and apply novel integrin ligands/agonists to promote stem cell and organoid growth Cryo-EM: Activation of integrins and TGF-β, and ligand binding Mechanobiology: Integrin force transduction in rolling adhesion and firm adhesion and TGF-β activation Single Molecules: Utilize advanced techniques including FRET and magnetic tweezers to explore conformational change kinetics and force transmission in integrins and selectins Innovative ReaLiSM: (Receptor and Ligand in Single Molecules) to study receptor-ligand binding dynamics TGF-β Activation: Research localized activation at cell surfaces for new therapeutic targets
Own and Develop Your Project: We encourage candidates to propose and develop their own research ideas, which they can carry forward to establish their own labs. Key Techniques and Approaches: Organoid and stem cell systems Single-molecule imaging Cryo-EM FRET reporters using non-canonical amino acids Magnetic and laser tweezers Mechanobiology and therapeutic target discovery Why Join Us? Mentorship from Tim Springer, renowned for his pioneering work in integrins and cell biology Work at the frontier of a rapidly expanding area bridging fundamental biophysics and translational biotech Independence and Growth: Develop projects that will empower your transition to an independent research career Collaborative environment at Harvard Medical School and Boston Children’s Hospital To apply, please email the following to springer_jobs@crystal.harvard.edu with "Special Postdoctoral Fellow - SC" in the subject line: Cover letter (include a brief outline of your project interests) CV Three references Salary: $78,000 annually Appointment: 1-year initial term, renewable (multi-year funding) Start: Fall 2025 Visa sponsorship: Available Qualified applicants will receive consideration without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status, or disability.
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About the Role: As a Special Postdoctoral Fellow, you will: Pursue cutting-edge research in areas such as:
Stem Cells and organoids: Develop and apply novel integrin ligands/agonists to promote stem cell and organoid growth Cryo-EM: Activation of integrins and TGF-β, and ligand binding Mechanobiology: Integrin force transduction in rolling adhesion and firm adhesion and TGF-β activation Single Molecules: Utilize advanced techniques including FRET and magnetic tweezers to explore conformational change kinetics and force transmission in integrins and selectins Innovative ReaLiSM: (Receptor and Ligand in Single Molecules) to study receptor-ligand binding dynamics TGF-β Activation: Research localized activation at cell surfaces for new therapeutic targets
Own and Develop Your Project: We encourage candidates to propose and develop their own research ideas, which they can carry forward to establish their own labs. Key Techniques and Approaches: Organoid and stem cell systems Single-molecule imaging Cryo-EM FRET reporters using non-canonical amino acids Magnetic and laser tweezers Mechanobiology and therapeutic target discovery Why Join Us? Mentorship from Tim Springer, renowned for his pioneering work in integrins and cell biology Work at the frontier of a rapidly expanding area bridging fundamental biophysics and translational biotech Independence and Growth: Develop projects that will empower your transition to an independent research career Collaborative environment at Harvard Medical School and Boston Children’s Hospital To apply, please email the following to springer_jobs@crystal.harvard.edu with "Special Postdoctoral Fellow - SC" in the subject line: Cover letter (include a brief outline of your project interests) CV Three references Salary: $78,000 annually Appointment: 1-year initial term, renewable (multi-year funding) Start: Fall 2025 Visa sponsorship: Available Qualified applicants will receive consideration without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status, or disability.
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