Legend Biotech
Overview
Legend Biotech is seeking a
Sr. Scientist
as part of the
Novel CAR Design
team based in
Piscataway, NJ . We are a leading cell therapy company with a commercial CAR drug product CARVYKTI and an attractive pipeline portfolio. The candidate will be an integral part of our R&D team, researching, developing and advancing the next generation of cell therapies using innovative in vivo delivery technologies and creating novel CAR designs for a wide range of human autoimmune disease indications. This position will focus on in-vivo CAR. The position requires enthusiasm, passion, outstanding skills in the art, diligence, and a desire to create new medicines for patients. Role Overview Key Responsibilities
Lead, design and optimize research with aims of exploring next generation cell therapies using in-vivo CAR-T. Contribute to project creation and formation through dissection of published literature to find novel solutions to in-vivo cell therapy problems. Isolate immune cells from leukopak or blood from healthy donors or patients and evaluate in-vivo CAR virus using in-vitro assays and in-vivo mice models. Perform research requiring cell biology techniques including cell culture, transfection, FACS, and cell-based assays. Package and titer engineered viruses to infect immune cells in vitro and in vivo; characterize virus particles with protein and PCR-based assays; measure transduction rate using flow and VCN analysis. Generate, manage, evaluate, and maintain critical data in a highly organized manner, including the use of ELN. Deliver results to meet timelines with accountability through presentations to internal group meetings and other forums. Maintain compliance with GLP and EHS protocols. Qualifications
PhD in Immunology or related discipline 4 years of experience in the field of cell therapy; in vivo CAR-T experience preferred Extensive experience in immune cell-based analytics and assay development including multi-parameter flow cytometry, immunogenicity assay such as mixed lymphocyte reaction assay, cytotoxicity assay, cytokine release ELISA/MSD multiplex assays Experience with lentivirus particle characterization and quantification using molecular (VCN) and flow-based assays Prior experience with delivery systems of transient expression is a plus Experience with autoimmune disease (AID) models is a plus Track record of productivity evidenced by publications or patents Ability to work independently to plan and timely execute research projects Deep knowledge of immunology and immunotherapy; understanding of AID is preferred Proficient in advanced gene delivery methods using LVV, VLP or genome editing technologies Strong experience with lentivirus production, titering and transduction Working molecular biology and cellular biology knowledge in design and evaluation of modified viral vectors Strong problem-solving and collaborative skills Excellent verbal and written communication skills The anticipated base pay range is:
$123,605 USD - $162,232 USD Benefits
We are committed to creating a workplace where employees can thrive — professionally and personally. Our best-in-class benefits include medical, dental, and vision insurance; a 401(k) retirement plan with company match; equity and stock options where eligible; eight weeks of paid parental leave after three months of employment; and a comprehensive time-off policy (15 vacation days, 5 personal days, 5 sick days, 11 U.S. holidays, 3 floating holidays). Additional benefits include flexible spending accounts, health savings accounts, life and AD&D insurance, disability coverage, legal assistance, and other voluntary plans. We also provide commuter benefits and well-being resources to support our employees.
EEO Statement
Legend Biotech is an equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law. Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions. Legend Biotech maintains a drug-free workplace. Seniority level
Mid-Senior level Employment type
Full-time Job function
Research, Analyst, and Information Technology
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Legend Biotech is seeking a
Sr. Scientist
as part of the
Novel CAR Design
team based in
Piscataway, NJ . We are a leading cell therapy company with a commercial CAR drug product CARVYKTI and an attractive pipeline portfolio. The candidate will be an integral part of our R&D team, researching, developing and advancing the next generation of cell therapies using innovative in vivo delivery technologies and creating novel CAR designs for a wide range of human autoimmune disease indications. This position will focus on in-vivo CAR. The position requires enthusiasm, passion, outstanding skills in the art, diligence, and a desire to create new medicines for patients. Role Overview Key Responsibilities
Lead, design and optimize research with aims of exploring next generation cell therapies using in-vivo CAR-T. Contribute to project creation and formation through dissection of published literature to find novel solutions to in-vivo cell therapy problems. Isolate immune cells from leukopak or blood from healthy donors or patients and evaluate in-vivo CAR virus using in-vitro assays and in-vivo mice models. Perform research requiring cell biology techniques including cell culture, transfection, FACS, and cell-based assays. Package and titer engineered viruses to infect immune cells in vitro and in vivo; characterize virus particles with protein and PCR-based assays; measure transduction rate using flow and VCN analysis. Generate, manage, evaluate, and maintain critical data in a highly organized manner, including the use of ELN. Deliver results to meet timelines with accountability through presentations to internal group meetings and other forums. Maintain compliance with GLP and EHS protocols. Qualifications
PhD in Immunology or related discipline 4 years of experience in the field of cell therapy; in vivo CAR-T experience preferred Extensive experience in immune cell-based analytics and assay development including multi-parameter flow cytometry, immunogenicity assay such as mixed lymphocyte reaction assay, cytotoxicity assay, cytokine release ELISA/MSD multiplex assays Experience with lentivirus particle characterization and quantification using molecular (VCN) and flow-based assays Prior experience with delivery systems of transient expression is a plus Experience with autoimmune disease (AID) models is a plus Track record of productivity evidenced by publications or patents Ability to work independently to plan and timely execute research projects Deep knowledge of immunology and immunotherapy; understanding of AID is preferred Proficient in advanced gene delivery methods using LVV, VLP or genome editing technologies Strong experience with lentivirus production, titering and transduction Working molecular biology and cellular biology knowledge in design and evaluation of modified viral vectors Strong problem-solving and collaborative skills Excellent verbal and written communication skills The anticipated base pay range is:
$123,605 USD - $162,232 USD Benefits
We are committed to creating a workplace where employees can thrive — professionally and personally. Our best-in-class benefits include medical, dental, and vision insurance; a 401(k) retirement plan with company match; equity and stock options where eligible; eight weeks of paid parental leave after three months of employment; and a comprehensive time-off policy (15 vacation days, 5 personal days, 5 sick days, 11 U.S. holidays, 3 floating holidays). Additional benefits include flexible spending accounts, health savings accounts, life and AD&D insurance, disability coverage, legal assistance, and other voluntary plans. We also provide commuter benefits and well-being resources to support our employees.
EEO Statement
Legend Biotech is an equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law. Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions. Legend Biotech maintains a drug-free workplace. Seniority level
Mid-Senior level Employment type
Full-time Job function
Research, Analyst, and Information Technology
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