Generate Biomedicines, Inc.
Senior Scientist I, Protein Engineering and Synthetic Biology Somerville, MA
Generate Biomedicines, Inc., Somerville, Massachusetts, us, 02145
Working together toward
limitless possibilities.
We are differentiated in the composition of our team, which includes individuals from all areas— science, technology, and business —who share apioneering mindset, and are passionate about finding better ways to create medicines for patients.
We seek diverse perspectives because we believe that engaging in candid, productive conflict around ideas is how we will push the boundaries of
the possible . Senior Scientist I, Protein Engineering and Synthetic Biology
About Generate:Biomedicines Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development. We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us! Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received nearly $700 millionin funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with 300+ employees. The Role: The Protein Engineering team is seeking a highly innovative and collaborative Senior Scientist I to drive the development and implementation of large-scale, NGS-based functional assays. In this role, you will lead the translation of Generate’s cutting-edge technologies into high-impact therapeutic applications that harness the full power of our computational and experimental platforms. This role will collaborate closely with teams across DNA Read/Write, Prototyping Lab, MachineLearning, and Early-Stage Biology to pioneer novel workflows for scalable functional screening. This is an ideal opportunity for a scientist who thrives at the interface of technology development and translational potential – someone who enjoys building new tools and using them to ask meaningful biological questions . Here's how you will contribute: Design and implement state-of-the art large-scale quantitative assays to evaluate the biological function of protein designs Collaborate with computational teams to guide experimental design and data analysis Translate emerging technologies from Prototyping Lab into scalable, validated platforms for therapeutic exploration Communicate experimental strategies, results, and insights clearly and effectively across multidisciplinary teams Support platform innovation with theoretical analysis, modeling, and literature review Generate novel intellectual property and contribute to patent filings The Ideal Candidate will have: PhD in biomedical engineering, synthetic or systems biology, biophysics, or related discipline with 4+ years of relevant experience or BS/MS with 10+ years of relevant experience.Exceptional candidates with fewer years of experience may also be considered Expertise in synthetic biology or protein engineering, with particular emphasis on DNA library construction, protein library screening, and NGS assay development Proficiency in computational analysis using Python, MATLAB, or related tools, particularly for NGS and high-throughput datasets Experience with gene editing technologies for developing engineered cell lines Strong quantitative mindset and scientific intuition Demonstrated ability to translate experimental tools into biologically meaningful applications Highly collaborative, intellectually curious, and motivated to work across disciplines Experience with computational modeling and/or laboratory automation is a plus #LI-AE1 Generate:Biomedicines is
committed to equal employment opportunity
regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies
: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto. Compensation:
The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package. Per Year Salary Range $124,000 - $174,000 USD Create a Job Alert Interested in building your career at Generate Biomedicines? Get future opportunities sent straight to your email. Apply for this job
* indicates a required field First Name * Last Name * Email * Phone * Resume/CV * Enter manually Accepted file types: pdf, doc, docx, txt, rtf Enter manually Accepted file types: pdf, doc, docx, txt, rtf Education School Select... Degree * Select... Address Line 1 * Street address Address Line 2 street address continued City * The city in which you reside State * Select... The State within the United States in which you reside Postal Code * Are you legally authorized to work in the United States? * Do you now or will you in the future require sponsorship to work in the U.S.? (e.g., H-1B, O-1, OPT, etc)? * Select... If you'll require the company to commence ("sponsor") an immigration or work permit case in order to employ you, either now or at some point in the future, then you should select Yes. Otherwise, select No. Are you able to work in the specified job location, or are you willing to relocate for this position? * Select... When are you able to begin a new position? * Do you have at least 1 year of experience analyzing NGS datasets using Python, MATLAB, or related computational tools? * Select... Do you have at least 2 years of experience with pooled library screens (including DNA library construction, screening, and assay development)? * Select... How many years of post educational experience do you have? * Do you know anyone who currently works at Generate:Biomedicines? If so, who? * How did you hear about this job? * Select... If other, please share source LinkedIn Profile Website What geographical area do you live in? * Select... Demographic Questions
At Generate Biomedicines, we value belonging and believe in fostering an environment where a diversity of perspectives can thrive. This core value is a pillar of our business and critical to our success. Your responses will be used (in aggregate only) to help us identifyareas of improvement in our process. Your responses will not be associated with your specific application and will not
in any way be used in the hiring decision. Completion of the form is entirely voluntary . How would you describe yourself as male, female, and/or transgender? (Select all that apply) Select... Which of the following best represents how you think of yourself? (Select all that apply) Select... How would you describe your race? (Select all that apply) Select... Are you of Hispanic, Latino, or Spanish origin? Select... Have you served on active duty in the U.S. Armed Forces, Reserves, or National Guard? Select...
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limitless possibilities.
We are differentiated in the composition of our team, which includes individuals from all areas— science, technology, and business —who share apioneering mindset, and are passionate about finding better ways to create medicines for patients.
We seek diverse perspectives because we believe that engaging in candid, productive conflict around ideas is how we will push the boundaries of
the possible . Senior Scientist I, Protein Engineering and Synthetic Biology
About Generate:Biomedicines Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development. We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us! Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received nearly $700 millionin funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with 300+ employees. The Role: The Protein Engineering team is seeking a highly innovative and collaborative Senior Scientist I to drive the development and implementation of large-scale, NGS-based functional assays. In this role, you will lead the translation of Generate’s cutting-edge technologies into high-impact therapeutic applications that harness the full power of our computational and experimental platforms. This role will collaborate closely with teams across DNA Read/Write, Prototyping Lab, MachineLearning, and Early-Stage Biology to pioneer novel workflows for scalable functional screening. This is an ideal opportunity for a scientist who thrives at the interface of technology development and translational potential – someone who enjoys building new tools and using them to ask meaningful biological questions . Here's how you will contribute: Design and implement state-of-the art large-scale quantitative assays to evaluate the biological function of protein designs Collaborate with computational teams to guide experimental design and data analysis Translate emerging technologies from Prototyping Lab into scalable, validated platforms for therapeutic exploration Communicate experimental strategies, results, and insights clearly and effectively across multidisciplinary teams Support platform innovation with theoretical analysis, modeling, and literature review Generate novel intellectual property and contribute to patent filings The Ideal Candidate will have: PhD in biomedical engineering, synthetic or systems biology, biophysics, or related discipline with 4+ years of relevant experience or BS/MS with 10+ years of relevant experience.Exceptional candidates with fewer years of experience may also be considered Expertise in synthetic biology or protein engineering, with particular emphasis on DNA library construction, protein library screening, and NGS assay development Proficiency in computational analysis using Python, MATLAB, or related tools, particularly for NGS and high-throughput datasets Experience with gene editing technologies for developing engineered cell lines Strong quantitative mindset and scientific intuition Demonstrated ability to translate experimental tools into biologically meaningful applications Highly collaborative, intellectually curious, and motivated to work across disciplines Experience with computational modeling and/or laboratory automation is a plus #LI-AE1 Generate:Biomedicines is
committed to equal employment opportunity
regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies
: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto. Compensation:
The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package. Per Year Salary Range $124,000 - $174,000 USD Create a Job Alert Interested in building your career at Generate Biomedicines? Get future opportunities sent straight to your email. Apply for this job
* indicates a required field First Name * Last Name * Email * Phone * Resume/CV * Enter manually Accepted file types: pdf, doc, docx, txt, rtf Enter manually Accepted file types: pdf, doc, docx, txt, rtf Education School Select... Degree * Select... Address Line 1 * Street address Address Line 2 street address continued City * The city in which you reside State * Select... The State within the United States in which you reside Postal Code * Are you legally authorized to work in the United States? * Do you now or will you in the future require sponsorship to work in the U.S.? (e.g., H-1B, O-1, OPT, etc)? * Select... If you'll require the company to commence ("sponsor") an immigration or work permit case in order to employ you, either now or at some point in the future, then you should select Yes. Otherwise, select No. Are you able to work in the specified job location, or are you willing to relocate for this position? * Select... When are you able to begin a new position? * Do you have at least 1 year of experience analyzing NGS datasets using Python, MATLAB, or related computational tools? * Select... Do you have at least 2 years of experience with pooled library screens (including DNA library construction, screening, and assay development)? * Select... How many years of post educational experience do you have? * Do you know anyone who currently works at Generate:Biomedicines? If so, who? * How did you hear about this job? * Select... If other, please share source LinkedIn Profile Website What geographical area do you live in? * Select... Demographic Questions
At Generate Biomedicines, we value belonging and believe in fostering an environment where a diversity of perspectives can thrive. This core value is a pillar of our business and critical to our success. Your responses will be used (in aggregate only) to help us identifyareas of improvement in our process. Your responses will not be associated with your specific application and will not
in any way be used in the hiring decision. Completion of the form is entirely voluntary . How would you describe yourself as male, female, and/or transgender? (Select all that apply) Select... Which of the following best represents how you think of yourself? (Select all that apply) Select... How would you describe your race? (Select all that apply) Select... Are you of Hispanic, Latino, or Spanish origin? Select... Have you served on active duty in the U.S. Armed Forces, Reserves, or National Guard? Select...
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