BioSpace
Senior Scientist - Oligonucleotide Conjugation
BioSpace, Thousand Oaks, California, United States, 91362
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Senior Scientist - Oligonucleotide Conjugation
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BioSpace Get AI-powered advice on this job and more exclusive features. Join Amgen's Mission of Serving Patients At Amgen, if you feel like youre part of something bigger, its because you are. Our shared mission to serve patients living with serious illnesses drives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Scientist - Oligonucleotide Conjugation What You Will Do Lets do this. Lets change the world. Responsibilities Design, synthesize, purify, and analytically characterize oligonucleotide conjugates, including optimizing synthesis/conjugation/purification protocols. Drive technical execution of conjugation projects from start to finish and perform hands-on conjugate synthesis (developing and optimizing conjugation strategies and purification methods). Serve as the oligonucleotide conjugation subject-matter expert (SME) in cross-functional team meetings. Conduct biophysical/biochemical assays (e.g. ELISA, SPR, FRET, BLI, DSF, DLS) to evaluate target binding and stability of oligonucleotide conjugates. Train as needed, collaborate with the Genetic Medicines group and cross-functional teams to meet project objectives and timelines. Prepare research results for presentations, patent applications, and scientific publications. (This role supports Amgen's pipeline of siRNA-based therapeutics.) Additional Responsibilities:
Perform hands-on
ligand, linker/spacer, and oligonucleotide synthesis
at mg-to-gram scales, including designing, purifying, analyzing synthetic products and optimizing synthetic protocols. Maintain detailed electronic lab notebooks and remain compliant on safety & required training. What We Expect Of You We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a Sr. Scientist with these qualifications. Basic Qualifications Doctorate degree (PhD OR PharmD OR MD) or Masters degree and 3 years of relevant experience Bachelors degree and 5 years of relevant experience Preferred Qualifications Ph.D. in Chemistry, Biochemistry, Chemical Engineering or related discipline with 3-5 years experience in biotech/pharma plus specific experience in oligonucleotide conjugation (designing, synthesizing, and characterizing oligo conjugates of small molecules, linkers, peptides, proteins, etc.). Expertise in conjugation chemistries and site-specific bioconjugation techniques, along with familiarity with RNA therapeutic modalities (ASO, siRNA, etc.). Proficiency in preparative and analytical chromatography techniques (IEX, RP-HPLC, SEC, LCMS) for oligonucleotides and conjugates thereof. Experience with automated oligonucleotide synthesizers and associated processes (on-resin conjugation, cleavage & deprotection, desalting, formulation) is a plus. Must demonstrate ability to conduct independent research and have strong communication/teamwork skills in a dynamic environment. What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. What Amgen Offers In addition to base salary, Amgen offers a Total Rewards Plan, comprising health and welfare plans, retirement savings, work-life balance, and career development opportunities. This includes: A comprehensive benefits package, including retirement and savings plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models where possible Apply now and make a lasting impact with the Amgen team. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Application deadline: Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. We will not be listing other job postings here. This description focuses on the Senior Scientist - Oligonucleotide Conjugation role at Amgen. Note: We are not including extraneous location/job feed snippets or unrelated content.
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Senior Scientist - Oligonucleotide Conjugation
role at
BioSpace Get AI-powered advice on this job and more exclusive features. Join Amgen's Mission of Serving Patients At Amgen, if you feel like youre part of something bigger, its because you are. Our shared mission to serve patients living with serious illnesses drives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Scientist - Oligonucleotide Conjugation What You Will Do Lets do this. Lets change the world. Responsibilities Design, synthesize, purify, and analytically characterize oligonucleotide conjugates, including optimizing synthesis/conjugation/purification protocols. Drive technical execution of conjugation projects from start to finish and perform hands-on conjugate synthesis (developing and optimizing conjugation strategies and purification methods). Serve as the oligonucleotide conjugation subject-matter expert (SME) in cross-functional team meetings. Conduct biophysical/biochemical assays (e.g. ELISA, SPR, FRET, BLI, DSF, DLS) to evaluate target binding and stability of oligonucleotide conjugates. Train as needed, collaborate with the Genetic Medicines group and cross-functional teams to meet project objectives and timelines. Prepare research results for presentations, patent applications, and scientific publications. (This role supports Amgen's pipeline of siRNA-based therapeutics.) Additional Responsibilities:
Perform hands-on
ligand, linker/spacer, and oligonucleotide synthesis
at mg-to-gram scales, including designing, purifying, analyzing synthetic products and optimizing synthetic protocols. Maintain detailed electronic lab notebooks and remain compliant on safety & required training. What We Expect Of You We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a Sr. Scientist with these qualifications. Basic Qualifications Doctorate degree (PhD OR PharmD OR MD) or Masters degree and 3 years of relevant experience Bachelors degree and 5 years of relevant experience Preferred Qualifications Ph.D. in Chemistry, Biochemistry, Chemical Engineering or related discipline with 3-5 years experience in biotech/pharma plus specific experience in oligonucleotide conjugation (designing, synthesizing, and characterizing oligo conjugates of small molecules, linkers, peptides, proteins, etc.). Expertise in conjugation chemistries and site-specific bioconjugation techniques, along with familiarity with RNA therapeutic modalities (ASO, siRNA, etc.). Proficiency in preparative and analytical chromatography techniques (IEX, RP-HPLC, SEC, LCMS) for oligonucleotides and conjugates thereof. Experience with automated oligonucleotide synthesizers and associated processes (on-resin conjugation, cleavage & deprotection, desalting, formulation) is a plus. Must demonstrate ability to conduct independent research and have strong communication/teamwork skills in a dynamic environment. What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. What Amgen Offers In addition to base salary, Amgen offers a Total Rewards Plan, comprising health and welfare plans, retirement savings, work-life balance, and career development opportunities. This includes: A comprehensive benefits package, including retirement and savings plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models where possible Apply now and make a lasting impact with the Amgen team. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Application deadline: Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. We will not be listing other job postings here. This description focuses on the Senior Scientist - Oligonucleotide Conjugation role at Amgen. Note: We are not including extraneous location/job feed snippets or unrelated content.
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