Flagship Pioneering, Inc.
Associate Director, Conjugate Chemistry
Flagship Pioneering, Inc., Cambridge, Massachusetts, us, 02140
Overview
Serif Biomedicines, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. Serif Biomedicines was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies, including Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture. The role We are seeking an outstanding
Associate Director
to join us in ideating and building the next generation of Programmable Medicines and lead a team of talented scientists. We are looking for strong scientific leadership skills, a drive to innovate, and deep domain experience in the development of targeted lipid nanoparticles. More broadly, we seek a candidate who brings scientific rigor, leadership and mentoring capabilities for a diverse team, intellectual curiosity, enthusiasm, and a desire to innovate in a highly collaborative environment. The role offers the opportunity to work in a dynamic, fast-paced entrepreneurial setting as part of a highly motivated and growing team. Key responsibilities Lead lipid nanoparticle (tLNP) design, development, and formulation, including binder selection, characterization, and conjugation chemistry. Deep experience with conjugation chemistry development, scaling, and translation. Expertise defining binder composition and characteristics for use in tLNP therapeutics, and experience driving their selection and functionalization. Proven ability to scale tLNP compositions in step with development progressing to IND. Experience in micro- to mid-scale LNP formulation using microfluidics platforms (e.g., Nanoassemblr) and familiarity with small-scale DOE approaches to assess protocol effects on yields and particle morphology. LNP purification and QC profiling and method development (DLS, HPLC/CAD, LCMS, encapsulation efficiency assays), especially related to conjugation reactions and the final tLNP product. Familiarity with targeted LNP and nanocarriers for cell-specific delivery. Deep understanding of molecular biology and nucleic acid therapeutics. In this role, you will interface with multiple departments and should have a general understanding of molecular biology, scale-up challenges, and delivering for in vivo studies. Proven track record of leadership and mentoring in a scientific setting, guiding a team through complex, cross-functional projects, coaching and developing team members, fostering cross-department collaboration, and providing clarity in fast-moving situations. Who you are Technical expert : Your Ph.D. is in chemistry, chemical engineering, biochemistry or biomedical engineering, with 5-8 years of industry experience focused on nucleic acid chemistry innovation, lipid synthesis and purification, and lipid nanoparticle formulation. Experienced manager and team leader : you have managed a team of research associates and junior scientists and are passionate about mentoring and creating an efficient, collaborative team. Mission-driven scientist : You are a deep scientific expert in lipid nanoparticle and nucleic acid formulation and value a team-centric, fast-paced environment with a drive to build something with global impact. Relentless pioneer : You thrive in new and unknown territory, can chart actionable plans, execute rapidly and iteratively, and deliver decisive readouts on time. Team player : You collaborate well with others and support colleagues’ challenges and celebrate victories. Effective communicator : You understand the science and can convey technical information clearly and decisively. Location:
Cambridge, MA Values and Behaviors
Flagship is an experiment in institutional, entrepreneurial, and innovation practice within a small company mindset. We seek individuals with an entrepreneurial spirit, strong communication skills, and the ability to contribute to a dynamic, cross-functional team environment. We recognize there is no perfect candidate; if you have some of the experience listed but not all, apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning about your background. The level of the role will be commensurate with education and experience. Flagship Pioneering and our ecosystem companies are
committed to equal employment opportunity
regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team.
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Serif Biomedicines, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. Serif Biomedicines was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies, including Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture. The role We are seeking an outstanding
Associate Director
to join us in ideating and building the next generation of Programmable Medicines and lead a team of talented scientists. We are looking for strong scientific leadership skills, a drive to innovate, and deep domain experience in the development of targeted lipid nanoparticles. More broadly, we seek a candidate who brings scientific rigor, leadership and mentoring capabilities for a diverse team, intellectual curiosity, enthusiasm, and a desire to innovate in a highly collaborative environment. The role offers the opportunity to work in a dynamic, fast-paced entrepreneurial setting as part of a highly motivated and growing team. Key responsibilities Lead lipid nanoparticle (tLNP) design, development, and formulation, including binder selection, characterization, and conjugation chemistry. Deep experience with conjugation chemistry development, scaling, and translation. Expertise defining binder composition and characteristics for use in tLNP therapeutics, and experience driving their selection and functionalization. Proven ability to scale tLNP compositions in step with development progressing to IND. Experience in micro- to mid-scale LNP formulation using microfluidics platforms (e.g., Nanoassemblr) and familiarity with small-scale DOE approaches to assess protocol effects on yields and particle morphology. LNP purification and QC profiling and method development (DLS, HPLC/CAD, LCMS, encapsulation efficiency assays), especially related to conjugation reactions and the final tLNP product. Familiarity with targeted LNP and nanocarriers for cell-specific delivery. Deep understanding of molecular biology and nucleic acid therapeutics. In this role, you will interface with multiple departments and should have a general understanding of molecular biology, scale-up challenges, and delivering for in vivo studies. Proven track record of leadership and mentoring in a scientific setting, guiding a team through complex, cross-functional projects, coaching and developing team members, fostering cross-department collaboration, and providing clarity in fast-moving situations. Who you are Technical expert : Your Ph.D. is in chemistry, chemical engineering, biochemistry or biomedical engineering, with 5-8 years of industry experience focused on nucleic acid chemistry innovation, lipid synthesis and purification, and lipid nanoparticle formulation. Experienced manager and team leader : you have managed a team of research associates and junior scientists and are passionate about mentoring and creating an efficient, collaborative team. Mission-driven scientist : You are a deep scientific expert in lipid nanoparticle and nucleic acid formulation and value a team-centric, fast-paced environment with a drive to build something with global impact. Relentless pioneer : You thrive in new and unknown territory, can chart actionable plans, execute rapidly and iteratively, and deliver decisive readouts on time. Team player : You collaborate well with others and support colleagues’ challenges and celebrate victories. Effective communicator : You understand the science and can convey technical information clearly and decisively. Location:
Cambridge, MA Values and Behaviors
Flagship is an experiment in institutional, entrepreneurial, and innovation practice within a small company mindset. We seek individuals with an entrepreneurial spirit, strong communication skills, and the ability to contribute to a dynamic, cross-functional team environment. We recognize there is no perfect candidate; if you have some of the experience listed but not all, apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning about your background. The level of the role will be commensurate with education and experience. Flagship Pioneering and our ecosystem companies are
committed to equal employment opportunity
regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team.
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