Antares Therapeutics
Sr. Research Associate I/II, Protein Purification (Drug Discovery)
Antares Therapeutics, Boston, Massachusetts, us, 02298
Job Summary
Antares Therapeutics is seeking a highly knowledgeable Senior Research Associate I/II to join the Protein and Structural Sciences team. This role is ideal for someone with exceptional protein purification experience who wants to advance drug discovery programs by enabling structural biology experiments. The successful candidate will collaborate with a team of structural biologists to plan and execute purifications of crystallography-grade proteins. This individual will also manage day-to-day operations in our protein production space. This is a unique opportunity to work at the intersection of structural biology and biochemistry in a fast-paced drug discovery setting.
Location Downtown Boston, MA
Salary $90,000-$130,000, dependent on experience
Key Responsibilities
Plan and prosecute gene-to-protein projects for a diverse set of Antares’s targets
Manage the protein production space and equipment
Work with team members to efficiently generate new crystallography-grade protein
Perform protein quality control and characterization
Collaborate on protein design with team members to enable structural biology
Occasional cross-functional work purifying protein for biochemistry or chemical biology groups
Report and present results and contribute to strategy on different project teams
Maintain excellent records and communication across internal and external colleagues
Coordinate with CRO partners to produce some proteins externally
Qualifications
Master’s degree and 5+ years of experience or Bachelor’s and 7+ years of experience in protein purification, ideally in a drug discovery setting
Demonstrated expertise in protein purification process development including broad experience with AKTA FPLC systems and knowledge of chromatography resins
Experience in bacterial expression systems and strains required
Ability to purify multiple, similar proteins in parallel
Capable of screening small groups of protein constructs for soluble expression
Experience evaluating the quality and biophysical characteristics of recombinant protein in different assays is a plus but not required
Experience with protein crystallography and NMR proteins is a plus but not required
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Location Downtown Boston, MA
Salary $90,000-$130,000, dependent on experience
Key Responsibilities
Plan and prosecute gene-to-protein projects for a diverse set of Antares’s targets
Manage the protein production space and equipment
Work with team members to efficiently generate new crystallography-grade protein
Perform protein quality control and characterization
Collaborate on protein design with team members to enable structural biology
Occasional cross-functional work purifying protein for biochemistry or chemical biology groups
Report and present results and contribute to strategy on different project teams
Maintain excellent records and communication across internal and external colleagues
Coordinate with CRO partners to produce some proteins externally
Qualifications
Master’s degree and 5+ years of experience or Bachelor’s and 7+ years of experience in protein purification, ideally in a drug discovery setting
Demonstrated expertise in protein purification process development including broad experience with AKTA FPLC systems and knowledge of chromatography resins
Experience in bacterial expression systems and strains required
Ability to purify multiple, similar proteins in parallel
Capable of screening small groups of protein constructs for soluble expression
Experience evaluating the quality and biophysical characteristics of recombinant protein in different assays is a plus but not required
Experience with protein crystallography and NMR proteins is a plus but not required
#J-18808-Ljbffr