SystImmune Inc.
Scientist/Senior Scientist, Upstream
SystImmune Inc., Redmond, Washington, United States, 98052
Overview
SystImmune is a leading and well-funded clinical-stage biopharmaceutical company with sites in Redmond, WA and Princeton, NJ. It specializes in cancer therapeutics using bi-specific, multi-specific antibodies and antibody-drug conjugates (ADCs). The company has assets in various stages of clinical trials for solid tumor and hematologic indications, along with a robust preclinical pipeline in discover and IND-enabling stages. We offer an opportunity for you to learn and grow while contributing to the companys success. Responsibilities
Apply technical knowledge in upstream process development for CHO cells (bioreactor process design, scale-up, media and feed optimization, etc.). Draft study protocols, design and execute experiments including in-process tests, characterize and deliver harvest material to downstream teams, and author technical reports. Stay abreast of technical advancements in CMC related to CHO cell line development, upstream process development, and technology transfer aligned with cGMP clinical manufacturing. Support transfer, development, and scale-up of CHO cell culture process technology from research into process development and manufacturing to enable production of clinical material. Collaborate with downstream process development and analytical development teams to advance recombinant protein programs. Lead and support elements of early-stage CMC development activities, including technical support of non-GMP and clinical manufacturing, and development and implementation of process improvements as programs advance. Analyze, interpret, and present complex technical information in statistically meaningful ways; apply DoE and multi-variant analysis. Work within the project scope, manage timelines in a fast-paced environment with rigor and agility, and communicate data effectively to management. Qualifications
PhD with 3+ years of experience in upstream bioprocess. Significant technical bioreactor use, optimization, and scale-up. DasGip or DASware experience is desired; perfusion experience is a plus. Ability to work independently to troubleshoot processes and develop new methods in a collaborative, flat matrix. Experience scaling up and transferring technology to manufacturing environments and a solid understanding of GMP. Knowledge in other areas of therapeutic protein process development (downstream, formulation, analytics) is valued. Exceptional communication and interpersonal skills; ability to foster positive relationships with stakeholders. Proactive in introducing new methods, providing technical mentorship, and keeping the lab efficient. Accuracy, attention to detail, and ability to manage multiple projects simultaneously. Compensation and Benefits
The expected base salary range for this position is $90,000 to $140,000 annually. Actual compensation will be based on qualifications, experience, and skills. While offers typically fall within the low to mid-point of the range, exceptional candidates may receive offers toward the higher end. SystImmune offers a comprehensive benefits package including 100% paid employee premiums for medical/dental/vision, STD, LTD, a 401(k) plan with a 50% company match up to 3% and a 5-year vesting, 15 PTO days per year, sick leave, 11 paid holidays, and more. Equal Employment Opportunity
SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply. This job description is intended to present the general content and requirements for this job. It is not an exhaustive statement of duties, responsibilities, or requirements. Managers and supervisors may assign other duties as needed.
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SystImmune is a leading and well-funded clinical-stage biopharmaceutical company with sites in Redmond, WA and Princeton, NJ. It specializes in cancer therapeutics using bi-specific, multi-specific antibodies and antibody-drug conjugates (ADCs). The company has assets in various stages of clinical trials for solid tumor and hematologic indications, along with a robust preclinical pipeline in discover and IND-enabling stages. We offer an opportunity for you to learn and grow while contributing to the companys success. Responsibilities
Apply technical knowledge in upstream process development for CHO cells (bioreactor process design, scale-up, media and feed optimization, etc.). Draft study protocols, design and execute experiments including in-process tests, characterize and deliver harvest material to downstream teams, and author technical reports. Stay abreast of technical advancements in CMC related to CHO cell line development, upstream process development, and technology transfer aligned with cGMP clinical manufacturing. Support transfer, development, and scale-up of CHO cell culture process technology from research into process development and manufacturing to enable production of clinical material. Collaborate with downstream process development and analytical development teams to advance recombinant protein programs. Lead and support elements of early-stage CMC development activities, including technical support of non-GMP and clinical manufacturing, and development and implementation of process improvements as programs advance. Analyze, interpret, and present complex technical information in statistically meaningful ways; apply DoE and multi-variant analysis. Work within the project scope, manage timelines in a fast-paced environment with rigor and agility, and communicate data effectively to management. Qualifications
PhD with 3+ years of experience in upstream bioprocess. Significant technical bioreactor use, optimization, and scale-up. DasGip or DASware experience is desired; perfusion experience is a plus. Ability to work independently to troubleshoot processes and develop new methods in a collaborative, flat matrix. Experience scaling up and transferring technology to manufacturing environments and a solid understanding of GMP. Knowledge in other areas of therapeutic protein process development (downstream, formulation, analytics) is valued. Exceptional communication and interpersonal skills; ability to foster positive relationships with stakeholders. Proactive in introducing new methods, providing technical mentorship, and keeping the lab efficient. Accuracy, attention to detail, and ability to manage multiple projects simultaneously. Compensation and Benefits
The expected base salary range for this position is $90,000 to $140,000 annually. Actual compensation will be based on qualifications, experience, and skills. While offers typically fall within the low to mid-point of the range, exceptional candidates may receive offers toward the higher end. SystImmune offers a comprehensive benefits package including 100% paid employee premiums for medical/dental/vision, STD, LTD, a 401(k) plan with a 50% company match up to 3% and a 5-year vesting, 15 PTO days per year, sick leave, 11 paid holidays, and more. Equal Employment Opportunity
SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply. This job description is intended to present the general content and requirements for this job. It is not an exhaustive statement of duties, responsibilities, or requirements. Managers and supervisors may assign other duties as needed.
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