Stoke Therapeutics, Inc.
Principal Scientist, Oligonucleotide Chemistry Bedford, Massachusetts, United St
Stoke Therapeutics, Inc., Oklahoma City, Oklahoma, United States
Overview
Bedford, Massachusetts, United States About Stoke:
Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company focused on restoring protein expression via RNA-based therapeutics. The company develops antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, is in a Phase 3 study for Dravet syndrome. Stoke has a strategic collaboration with Biogen (2025) to develop and commercialize zorevunersen for Dravet syndrome; Stoke retains US, Canada, and Mexico rights, while Biogen holds exclusive rest-of-world rights. Stoke’s initial TANGO platform focus is on CNS and eye diseases caused by haploinsufficiency (loss of ~50% of normal protein). The company is pursuing STK-002 for autosomal dominant optic atrophy (ADOA) and a potential new medicine for Syngap1 in collaboration with Acadia Pharmaceuticals. Proof of concept has been demonstrated in other tissues, supporting broad potential for the approach. Position Purpose
We are seeking a dedicated and highly motivated Principal Scientist in Oligonucleotide Chemistry to join a dynamic team advancing oligonucleotide-based therapeutics. You will work within the chemistry team to manage synthesis of bioactive oligonucleotides for drug discovery programs and deliver to project teams within strict timelines. Successful candidates will have significant experience with solid-phase chemical synthesis of oligonucleotides, conjugation, HPLC purification, and LC-MS analysis. This position reports to the Director, Chemistry. Key Responsibilities
Independently design and implement scientific and synthesis strategies for antisense and other synthetic oligonucleotide therapeutics. Contribute to multiple projects and provide technical knowledge to project teams. Plan and execute solid-phase oligonucleotide synthesis for SAR campaigns on several projects. Identify, develop, validate, and implement current and next-generation technologies to enable proprietary ASO therapeutic development, including procurement and installation of hardware/software for synthesis, purification, and characterization of oligonucleotides. Demonstrate working knowledge of conjugation chemistry to produce novel conjugates. Understand nucleoside/nucleotide/oligonucleotide chemistry as applied to antisense and related technologies. Stay current with scientific literature and state-of-the-art in oligonucleotide chemistry, purification, and screening strategies. Collaborate with internal chemistry teams and external CROs to solve synthetic and drug-design challenges in oligonucleotide drug discovery. Author reports and manuscripts; may contribute to patent filings and regulatory submissions. Required Skills & Experience
PhD in Oligonucleotide Chemistry with relevant drug discovery experience; or Master’s with 12+ years, or Bachelor’s with 18+ years in oligonucleotide synthesis. Strong practical knowledge of design, synthesis, and purification of synthetic oligonucleotides. Experience in scale-up synthesis is a plus. Excellent project/time management and problem-solving skills. Excellent written and verbal communication, including presenting to diverse audiences and communicating complex scientific concepts to program teams. Strong collaboration and ability to thrive in a team-driven environment. Experience designing, synthesizing, and purifying oligonucleotides to support research and scale-up studies. Proven track record of scientific contributions in oligonucleotide and conjugate research evidenced by publications/presentations/patents and/or identification of preclinical development candidates. Location & Travel
Location: Stoke operates in Bedford, MA. This is a lab-based position in Bedford, MA. Travel: Approximately 0% travel. Culture, Values & Benefits
Stoke values innovation, collaboration, and a culture of in-person interaction complemented by flexible work arrangements. The company is committed to diversity, inclusion, and belonging, guided by an employee-led DIB committee. Benefits include medical, dental, vision, life, disability insurance; Paid Parental Leave; 401(k) with company match; unlimited vacation; and an Employee Stock Purchase Program. Compensation is market-competitive and bonus/stock eligible. Interested candidates:
Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center. All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status. Stoke participates in E-Verify.
#J-18808-Ljbffr
Bedford, Massachusetts, United States About Stoke:
Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company focused on restoring protein expression via RNA-based therapeutics. The company develops antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, is in a Phase 3 study for Dravet syndrome. Stoke has a strategic collaboration with Biogen (2025) to develop and commercialize zorevunersen for Dravet syndrome; Stoke retains US, Canada, and Mexico rights, while Biogen holds exclusive rest-of-world rights. Stoke’s initial TANGO platform focus is on CNS and eye diseases caused by haploinsufficiency (loss of ~50% of normal protein). The company is pursuing STK-002 for autosomal dominant optic atrophy (ADOA) and a potential new medicine for Syngap1 in collaboration with Acadia Pharmaceuticals. Proof of concept has been demonstrated in other tissues, supporting broad potential for the approach. Position Purpose
We are seeking a dedicated and highly motivated Principal Scientist in Oligonucleotide Chemistry to join a dynamic team advancing oligonucleotide-based therapeutics. You will work within the chemistry team to manage synthesis of bioactive oligonucleotides for drug discovery programs and deliver to project teams within strict timelines. Successful candidates will have significant experience with solid-phase chemical synthesis of oligonucleotides, conjugation, HPLC purification, and LC-MS analysis. This position reports to the Director, Chemistry. Key Responsibilities
Independently design and implement scientific and synthesis strategies for antisense and other synthetic oligonucleotide therapeutics. Contribute to multiple projects and provide technical knowledge to project teams. Plan and execute solid-phase oligonucleotide synthesis for SAR campaigns on several projects. Identify, develop, validate, and implement current and next-generation technologies to enable proprietary ASO therapeutic development, including procurement and installation of hardware/software for synthesis, purification, and characterization of oligonucleotides. Demonstrate working knowledge of conjugation chemistry to produce novel conjugates. Understand nucleoside/nucleotide/oligonucleotide chemistry as applied to antisense and related technologies. Stay current with scientific literature and state-of-the-art in oligonucleotide chemistry, purification, and screening strategies. Collaborate with internal chemistry teams and external CROs to solve synthetic and drug-design challenges in oligonucleotide drug discovery. Author reports and manuscripts; may contribute to patent filings and regulatory submissions. Required Skills & Experience
PhD in Oligonucleotide Chemistry with relevant drug discovery experience; or Master’s with 12+ years, or Bachelor’s with 18+ years in oligonucleotide synthesis. Strong practical knowledge of design, synthesis, and purification of synthetic oligonucleotides. Experience in scale-up synthesis is a plus. Excellent project/time management and problem-solving skills. Excellent written and verbal communication, including presenting to diverse audiences and communicating complex scientific concepts to program teams. Strong collaboration and ability to thrive in a team-driven environment. Experience designing, synthesizing, and purifying oligonucleotides to support research and scale-up studies. Proven track record of scientific contributions in oligonucleotide and conjugate research evidenced by publications/presentations/patents and/or identification of preclinical development candidates. Location & Travel
Location: Stoke operates in Bedford, MA. This is a lab-based position in Bedford, MA. Travel: Approximately 0% travel. Culture, Values & Benefits
Stoke values innovation, collaboration, and a culture of in-person interaction complemented by flexible work arrangements. The company is committed to diversity, inclusion, and belonging, guided by an employee-led DIB committee. Benefits include medical, dental, vision, life, disability insurance; Paid Parental Leave; 401(k) with company match; unlimited vacation; and an Employee Stock Purchase Program. Compensation is market-competitive and bonus/stock eligible. Interested candidates:
Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center. All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status. Stoke participates in E-Verify.
#J-18808-Ljbffr