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Intelliswift Software

Bioinformatics Scientist II

Intelliswift Software, Cambridge, Massachusetts, United States, 02238

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Job ID: 25-10081

Job Title:

Bioinformatics Scientist - II Duration:

23 months, 40 hrs / week

Location:

Cambridge, MA 02141

Qualifications:

Required Qualifications:

•Ph.D. in Computational Biology or a related field.

•A proven track record of over 3 years in multi-omics analysis.

•Fundamental understanding of statistical methods and multi-omics data analysis and integration (e.g., RNA-Seq, single-cell RNA-Seq, genotype, spatial transcriptomics, OLINK).

•Proficiency in R, Python, and Bash, with the ability to establish best practices for reproducible data analyses.

•Experience with high-performance computing (HPC) systems and AWS Cloud Computing (e.g., IAM, S3 buckets).

•A collaborative and self-motivated individual with a strong work ethic, capable of managing multiple objectives in a dynamic environment and adapting to changing priorities.

•Excellent written and verbal communication skills.

Preferred Qualifications:

•Experience in processing and analyzing real-world data.

•Familiarity with spatial transcriptomics analysis.

•Knowledge of statistical and population genetics principles.

Responsibilities:

Location: Cambridge, MA

Key Responsibilities:

•Data Ingestion: Query external databases to acquire relevant multi-omics datasets (e.g., PubMed, Gene Expression Omnibus, ArrayExpress, gnomAD, GTEx, Ensembl).

•RNA-seq Analysis: Perform quality control (QC) and analysis of bulk and single-cell RNA-seq data using state-of-the-art methods (e.g., FastQC, STAR, Limma, DESeq2, clusterProfiler, Seurat, scanpy, LeafCutter).

•Multi-Omics Analysis: Analyze diverse molecular data types including spatial transcriptomics (e.g., Slide-seq, MERFISH, squidpy) and proteomics (e.g., OLINK, mass spectrometry-based approaches).

•Data Integration: Integrate multi-omics datasets, including gene/protein expression, mRNA splicing, spatial transcriptomics, and genotype data.

•Documentation: Prepare detailed documentation of analysis methods and results in a timely manner.