Scientist, RNA Conjugation & Synthesis Job at Alnylam Pharmaceuticals in Cambrid

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The RNAi Discovery group at Alnylam is seeking a passionate, creative scientist to join our highly interdisciplinary team focused on the advancement of our RNAi Platform and Lead Development efforts through novel approaches towards a deeper mechanistic/structural understanding of RNAi. The successful candidate will have a strong background in oligonucleotide chemistry/biochemistry through in-depth hands-on experience in the synthesis and chemical/biophysical characterization of oligonucleotides as well as their potential biological applications.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Conjugate novel ligands, including small molecules, peptides, and proteins, to oligonucleotides for delivery.
• Help to oversee and improve purification of oligonucleotides using various chromatography techniques.
• Collaborate with biology and chemistry colleagues to identify priority ligand-receptor pairs and develop targeting strategies.
• Design and execute the automated synthesis, purification, and analysis of siRNAs with various chemistries and scales using state-of-the-art instrumentation platforms.
• Improve and/or develop new processes to expand upon current capabilities.
• Troubleshoot and perform routine maintenance on critical instrumentation such as automated synthesis platforms, HPLC, and liquid handling robots.
• Work closely with members across various sub teams within RNAi discovery.
• Analyze, organize, and present data at internal meetings.

Qualifications

• PhD in Chemistry, Biochemistry, or related discipline with 0-3 years post-degree experience in an industrial or academic setting.
• Solid-phase synthesis techniques with oligonucleotides or peptides is desired.
• Expertise in chromatography purification techniques and troubleshooting.
• Strong laboratory skills and experience with analytical instrumentation such as HPLC, LC-MS, etc. with the ability to analyze, interpret, and clearly present data.
• The ability to apply his/her knowledge to a new area of study as well as to thrive in a highly interdisciplinary team environment with excellent oral and written communication skills.
• High degree of flexibility and motivation in a fast-paced work environment.

About Alnylam: We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.