Gilead Sciences
At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe.
We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations.
Job Description
We are seeking a highly motivated and creative Research Scientist to join the Discovery Sciences and Technologies (DST) Department and contribute to our biophysics capabilities to enable the identification and nomination of small molecule and biologics drug candidates across all therapeutic areas at Gilead. DST Department members are responsible for the design and execution of rigorous, quantitative, in vitro biochemical, biophysical, and functional cellular assays. They collaborate within multi-disciplinary teams to discover and evolve drug candidates from lead identification efforts during project inception to the characterization of the final development candidate. Specific Responsibilities
Apply steady-state and pre-steady-state kinetic assays to characterize enzyme targets and inhibitor mechanism of action Experience with mass spectrometry-based and biosensor approaches for lead ID characterization of novel and traditional drug modalities including PROTACs, molecular glues and covalent inhibitors Strong technical background in cellular assay development and signaling pathways Must be both a critical and creative thinker and be able to apply an advanced level of understanding and analytical skills to interpret data and draw conclusions within the broader context of project goals Able to troubleshoot and optimize assays as needed, identifying, and applying novel techniques or proactively seeking out solutions Perform critical experiments to enable hit identification and lead optimization across therapeutic modalities Provide scientific insight and in-depth data interpretation to inform decision making at the project team and leadership levels Evaluate and implement new technologies to support advancement of internal programs and core group functions Contribute to several projects at any given time, work successfully in a cross-functional team environment, and communicate clearly both verbally and in writing to a variety of audiences Basic Qualifications
Bachelor's Degree and 6 years experience OR Master's Degree and 4 years experience Preferred Qualifications
Ph.D. with a minimum of 2 years of experience, or an M.Sc. with 5-7 years of experience in biochemistry, enzymology, biophysics or a related scientific discipline and direct experience in assay development and/or inhibitor mechanism of action studies. Background in classical enzymology and biophysics (SPR ITC, MST, KinExA), including steady-state and pre-steady-state kinetics, thermodynamics, and reaction mechanism Expertise in a broad range of assay formats including activity assays, competitive binding assays, and direct binding assays to identify and characterize small molecules and biologics. Practical experience applying mass spec approaches for drug discovery and experience studying covalent and degrader small molecule modalities would be advantageous. Strong analytical skills and a solid understanding of rate equations and data fitting statistics Excellent verbal and written communication skills to disseminate information to direct colleagues and broad audiences Track record of productivity in diverse work environments The candidate should be able to think critically and creatively across multiple disciplines and have demonstrated the ability to answer complex scientific questions using a variety of biophysical techniques e.g. mass spectrometry Experience with automation is a definite plus Must be detail-orientated and extremely well-organized Strong interpersonal and communication skills, with enthusiasm for working in a driven environment characterized by rigorous scientific and innovative thinking Excellent written and oral organizational skills The salary range for this position is: $146,540.00 - $189,640.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences.
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We are seeking a highly motivated and creative Research Scientist to join the Discovery Sciences and Technologies (DST) Department and contribute to our biophysics capabilities to enable the identification and nomination of small molecule and biologics drug candidates across all therapeutic areas at Gilead. DST Department members are responsible for the design and execution of rigorous, quantitative, in vitro biochemical, biophysical, and functional cellular assays. They collaborate within multi-disciplinary teams to discover and evolve drug candidates from lead identification efforts during project inception to the characterization of the final development candidate. Specific Responsibilities
Apply steady-state and pre-steady-state kinetic assays to characterize enzyme targets and inhibitor mechanism of action Experience with mass spectrometry-based and biosensor approaches for lead ID characterization of novel and traditional drug modalities including PROTACs, molecular glues and covalent inhibitors Strong technical background in cellular assay development and signaling pathways Must be both a critical and creative thinker and be able to apply an advanced level of understanding and analytical skills to interpret data and draw conclusions within the broader context of project goals Able to troubleshoot and optimize assays as needed, identifying, and applying novel techniques or proactively seeking out solutions Perform critical experiments to enable hit identification and lead optimization across therapeutic modalities Provide scientific insight and in-depth data interpretation to inform decision making at the project team and leadership levels Evaluate and implement new technologies to support advancement of internal programs and core group functions Contribute to several projects at any given time, work successfully in a cross-functional team environment, and communicate clearly both verbally and in writing to a variety of audiences Basic Qualifications
Bachelor's Degree and 6 years experience OR Master's Degree and 4 years experience Preferred Qualifications
Ph.D. with a minimum of 2 years of experience, or an M.Sc. with 5-7 years of experience in biochemistry, enzymology, biophysics or a related scientific discipline and direct experience in assay development and/or inhibitor mechanism of action studies. Background in classical enzymology and biophysics (SPR ITC, MST, KinExA), including steady-state and pre-steady-state kinetics, thermodynamics, and reaction mechanism Expertise in a broad range of assay formats including activity assays, competitive binding assays, and direct binding assays to identify and characterize small molecules and biologics. Practical experience applying mass spec approaches for drug discovery and experience studying covalent and degrader small molecule modalities would be advantageous. Strong analytical skills and a solid understanding of rate equations and data fitting statistics Excellent verbal and written communication skills to disseminate information to direct colleagues and broad audiences Track record of productivity in diverse work environments The candidate should be able to think critically and creatively across multiple disciplines and have demonstrated the ability to answer complex scientific questions using a variety of biophysical techniques e.g. mass spectrometry Experience with automation is a definite plus Must be detail-orientated and extremely well-organized Strong interpersonal and communication skills, with enthusiasm for working in a driven environment characterized by rigorous scientific and innovative thinking Excellent written and oral organizational skills The salary range for this position is: $146,540.00 - $189,640.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences.
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