BioSpace
Overview
Scientist (Seattle, WA) – Regeneron Pharmaceuticals, Inc. seeks a Scientist to assist with researching literature and market landscape to identify potential therapeutic targets and associated product concepts. Devise experimental plans to validate identified targets. Generate libraries of immunotherapeutic proteins and perform assay-based screening to identify promising hits. Perform standard T cell characterization assays, including cocultures to evaluate antigen specificity, target cell cytotoxicity, and T cell proliferation. Analyze high-throughput data using bioinformatics workflows in R and adjust parameters as necessary. Employ state-of-the-art automation instruments and collaborate with automation scientists to refine protocols. Provide guidance and mentorship to junior interns. Interpret and present data at working groups to help the broader department make data-driven decisions. 4% domestic travel required. Responsibilities
Research literature and market landscape to identify potential therapeutic targets and associated product concepts. Devise experimental plans to validate identified targets. Generate libraries of immunotherapeutic proteins and perform assay-based screening to identify promising hits. Perform standard T cell characterization assays, including cocultures to evaluate antigen specificity, target cell cytotoxicity, and T cell proliferation. Analyze high-throughput data using bioinformatics workflows in R and adjust parameters as necessary. Utilize automation instruments and collaborate with automation scientists to refine protocols. Provide guidance and mentorship to junior interns. Interpret and present data at working groups to support data-driven decisions within the department. Travel: 4% domestic travel required. Qualifications
Bachelor’s degree in Cell and Molecular Biology, Immunology, Biochemistry, Biology or related field or Master’s degree with corresponding experience. 3 years (Bachelor’s) or 1 year (Master’s) of pharmaceutical/biotech industry research experience. Experience with cell signaling pathways, protein engineering, cancer immunotherapies; DNA construct design and cloning, including large-scale library cloning and quality assessment using Next-Generation Sequencing. Mammalian cell culture and cell line engineering by CRISPR-Cas9 genome editing. Experience with automation platforms (e.g., Hamilton, Integra Assist Plus) and multicolor flow cytometry including FACS; data analysis with FlowJo and GraphPad Prism. Bioinformatic analysis of sequence data using R and/or Python. Ability to manage multiple projects simultaneously and communicate results effectively in team settings. Scientific publications in the pharmaceutical/biotech industry research field preferred. We have an inclusive & diverse culture that provides comprehensive benefits. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity or gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will provide reasonable accommodation to known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business. For roles in the U.S., salary ranges are shown in accordance with U.S. law and apply to U.S.-based positions. For roles based in Japan and/or Canada, ranges follow local law and currency. If you are outside the U.S, Japan or Canada, please discuss salaries and benefits with your recruiter. Background checks may be conducted in accordance with local law.
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Scientist (Seattle, WA) – Regeneron Pharmaceuticals, Inc. seeks a Scientist to assist with researching literature and market landscape to identify potential therapeutic targets and associated product concepts. Devise experimental plans to validate identified targets. Generate libraries of immunotherapeutic proteins and perform assay-based screening to identify promising hits. Perform standard T cell characterization assays, including cocultures to evaluate antigen specificity, target cell cytotoxicity, and T cell proliferation. Analyze high-throughput data using bioinformatics workflows in R and adjust parameters as necessary. Employ state-of-the-art automation instruments and collaborate with automation scientists to refine protocols. Provide guidance and mentorship to junior interns. Interpret and present data at working groups to help the broader department make data-driven decisions. 4% domestic travel required. Responsibilities
Research literature and market landscape to identify potential therapeutic targets and associated product concepts. Devise experimental plans to validate identified targets. Generate libraries of immunotherapeutic proteins and perform assay-based screening to identify promising hits. Perform standard T cell characterization assays, including cocultures to evaluate antigen specificity, target cell cytotoxicity, and T cell proliferation. Analyze high-throughput data using bioinformatics workflows in R and adjust parameters as necessary. Utilize automation instruments and collaborate with automation scientists to refine protocols. Provide guidance and mentorship to junior interns. Interpret and present data at working groups to support data-driven decisions within the department. Travel: 4% domestic travel required. Qualifications
Bachelor’s degree in Cell and Molecular Biology, Immunology, Biochemistry, Biology or related field or Master’s degree with corresponding experience. 3 years (Bachelor’s) or 1 year (Master’s) of pharmaceutical/biotech industry research experience. Experience with cell signaling pathways, protein engineering, cancer immunotherapies; DNA construct design and cloning, including large-scale library cloning and quality assessment using Next-Generation Sequencing. Mammalian cell culture and cell line engineering by CRISPR-Cas9 genome editing. Experience with automation platforms (e.g., Hamilton, Integra Assist Plus) and multicolor flow cytometry including FACS; data analysis with FlowJo and GraphPad Prism. Bioinformatic analysis of sequence data using R and/or Python. Ability to manage multiple projects simultaneously and communicate results effectively in team settings. Scientific publications in the pharmaceutical/biotech industry research field preferred. We have an inclusive & diverse culture that provides comprehensive benefits. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity or gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will provide reasonable accommodation to known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business. For roles in the U.S., salary ranges are shown in accordance with U.S. law and apply to U.S.-based positions. For roles based in Japan and/or Canada, ranges follow local law and currency. If you are outside the U.S, Japan or Canada, please discuss salaries and benefits with your recruiter. Background checks may be conducted in accordance with local law.
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