Legend Biotech
Senior Scientist/Principal Scientist, Quantitative Pharmacology
Legend Biotech, Trenton, New Jersey, United States
Overview
Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide. Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize cilta-cel. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma. Legend Biotech is seeking
Senior Scientist/Principal Scientist, Quantitative Pharmacology
as part of the
Research & Early Development
team based in
Somerset, NJ . Role Overview
The position seeks a highly motivated and experienced quantitative pharmacologist to lead modeling and simulation efforts in support of gene and cell therapy products, with a focus on QSP and popPK modeling (prior cell and gene therapy experience preferred). Key Responsibilities
Lead QSP and popPK modeling activities across preclinical and clinical development stages. Play a pivotal role in shaping clinical pharmacology strategies, supporting regulatory submissions, and driving innovation in model-informed drug development (MIDD). Develop and apply mechanistic models to understand disease pathways, drug mechanisms, and patient variability. Conduct simulations to support dose selection, trial design, and exposure-response analyses. Collaborate cross-functionally with R&D, clinical, regulatory, and biostatistics teams. Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs). Contribute to scientific publications and conference presentations. Qualifications
MS/PhD/Pharm D in Pharmaceutical Sciences, Clinical Pharmacology, Applied Mathematics, Biomedical Engineering, or related quantitative discipline. 7+ years with MS degree or 3+ years with PhD/Pharm D degree of working experience in quantitative pharmacology or pharmacometrics in pharmaceutical companies or CRO companies (titles decided per applicant’s experience). Strong execution ability and independent scientific research skills; good written and verbal communication. Demonstrated expertise in QSP and popPK modeling, including proficiency with NONMEM, R, MATLAB, Monolix, or equivalent tools. Deep understanding of PK/PD principles, translational medicine, and the role of quantitative pharmacology and MIDD in clinical trials. Experience applying modeling and simulation to enable rational preclinical and clinical drug development; familiarity with regulatory requirements and guidelines for clinical pharmacology. Good project management skills and ability to collaborate with multiple departments and external partners. Proven track record of scientific contributions through publications or presentations. Team-oriented attitude with strong problem-solving skills and professional integrity. Benefits
We are committed to creating a workplace where employees can thrive—professionally and personally. Our benefits package supports well-being, financial stability, and long-term career growth, and includes medical, dental, and vision insurance, a 401(k) plan with company match, equity or stock options in eligible roles, generous parental leave, paid time off, flexible spending and health savings accounts, life and disability insurance, and various supplemental plans. We also offer commuter benefits and well-being programs. EEO Statement
Legend Biotech is an equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital status, genetic information, citizenship status, veteran status, or any other characteristic protected by applicable law.
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Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide. Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize cilta-cel. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma. Legend Biotech is seeking
Senior Scientist/Principal Scientist, Quantitative Pharmacology
as part of the
Research & Early Development
team based in
Somerset, NJ . Role Overview
The position seeks a highly motivated and experienced quantitative pharmacologist to lead modeling and simulation efforts in support of gene and cell therapy products, with a focus on QSP and popPK modeling (prior cell and gene therapy experience preferred). Key Responsibilities
Lead QSP and popPK modeling activities across preclinical and clinical development stages. Play a pivotal role in shaping clinical pharmacology strategies, supporting regulatory submissions, and driving innovation in model-informed drug development (MIDD). Develop and apply mechanistic models to understand disease pathways, drug mechanisms, and patient variability. Conduct simulations to support dose selection, trial design, and exposure-response analyses. Collaborate cross-functionally with R&D, clinical, regulatory, and biostatistics teams. Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs). Contribute to scientific publications and conference presentations. Qualifications
MS/PhD/Pharm D in Pharmaceutical Sciences, Clinical Pharmacology, Applied Mathematics, Biomedical Engineering, or related quantitative discipline. 7+ years with MS degree or 3+ years with PhD/Pharm D degree of working experience in quantitative pharmacology or pharmacometrics in pharmaceutical companies or CRO companies (titles decided per applicant’s experience). Strong execution ability and independent scientific research skills; good written and verbal communication. Demonstrated expertise in QSP and popPK modeling, including proficiency with NONMEM, R, MATLAB, Monolix, or equivalent tools. Deep understanding of PK/PD principles, translational medicine, and the role of quantitative pharmacology and MIDD in clinical trials. Experience applying modeling and simulation to enable rational preclinical and clinical drug development; familiarity with regulatory requirements and guidelines for clinical pharmacology. Good project management skills and ability to collaborate with multiple departments and external partners. Proven track record of scientific contributions through publications or presentations. Team-oriented attitude with strong problem-solving skills and professional integrity. Benefits
We are committed to creating a workplace where employees can thrive—professionally and personally. Our benefits package supports well-being, financial stability, and long-term career growth, and includes medical, dental, and vision insurance, a 401(k) plan with company match, equity or stock options in eligible roles, generous parental leave, paid time off, flexible spending and health savings accounts, life and disability insurance, and various supplemental plans. We also offer commuter benefits and well-being programs. EEO Statement
Legend Biotech is an equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital status, genetic information, citizenship status, veteran status, or any other characteristic protected by applicable law.
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