Legend Biotech US
Senior Scientist/Principal Scientist, Quantitative Pharmacology
Legend Biotech US, Trenton, New Jersey, United States
Overview
Legend Biotech is a global biotechnology company focused on developing and commercializing cell therapies. The role is based in Somerset, New Jersey. Role
Senior Scientist/Principal Scientist, Quantitative Pharmacology is part of the Research & Early Development team. The candidate will lead modeling and simulation efforts for gene and cell therapy products, with a focus on QSP and popPK modeling. Prior cell and gene therapy experience is preferred. Key Responsibilities
Lead QSP and popPK modeling activities across preclinical and clinical development stages. Shape clinical pharmacology strategies, support regulatory submissions, and drive model-informed drug development (MIDD) initiatives. Develop and apply mechanistic models to understand disease pathways, drug mechanisms, and patient variability. Conduct simulations to support dose selection, trial design, and exposure–response analyses. Collaborate cross-functionally with R&D, clinical, regulatory, and biostatistics teams. Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs). Contribute to scientific publications and conference presentations. Requirements
Experience across R&D, Preclinical development, Clinical, CMC and regulatory areas. MS/PhD/Pharm D in Pharmaceutical Sciences, Clinical Pharmacology, Applied Mathematics, Biomedical Engineering, or related quantitative discipline. 7+ years with MS or 3+ years with PhD/Pharm D in quantitative pharmacology or pharmacometrics in pharmaceutical companies or CROs (titles determined by experience). Strong execution ability, independent scientific research capability, logical thinking, and coordination/problem-solving skills. Clear written and oral communication, good teamwork. Demonstrated expertise in QSP and popPK modeling with tools such as NONMEM, R, MATLAB, Monolix, etc. Deep understanding of PK/PD, translational medicine, and MIDD in clinical trials and drug development. Experience applying modeling and simulation to enable efficient preclinical and clinical development. Familiarity with regulatory requirements and guidelines for clinical pharmacology. Good project management and cross-functional collaboration skills. Proven scientific contributions through publications or presentations. Professional integrity and reliability. Benefits
We offer a best-in-class benefits package supporting well-being, financial stability, and long-term career growth. Highlights include medical, dental, and vision insurance, a 401(k) plan with company match, equity and stock options for eligible roles, paid parental leave, paid time off, holidays, and a range of other flexible benefits and wellness programs. EEO Statement
Legend Biotech is an equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law.
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Legend Biotech is a global biotechnology company focused on developing and commercializing cell therapies. The role is based in Somerset, New Jersey. Role
Senior Scientist/Principal Scientist, Quantitative Pharmacology is part of the Research & Early Development team. The candidate will lead modeling and simulation efforts for gene and cell therapy products, with a focus on QSP and popPK modeling. Prior cell and gene therapy experience is preferred. Key Responsibilities
Lead QSP and popPK modeling activities across preclinical and clinical development stages. Shape clinical pharmacology strategies, support regulatory submissions, and drive model-informed drug development (MIDD) initiatives. Develop and apply mechanistic models to understand disease pathways, drug mechanisms, and patient variability. Conduct simulations to support dose selection, trial design, and exposure–response analyses. Collaborate cross-functionally with R&D, clinical, regulatory, and biostatistics teams. Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs). Contribute to scientific publications and conference presentations. Requirements
Experience across R&D, Preclinical development, Clinical, CMC and regulatory areas. MS/PhD/Pharm D in Pharmaceutical Sciences, Clinical Pharmacology, Applied Mathematics, Biomedical Engineering, or related quantitative discipline. 7+ years with MS or 3+ years with PhD/Pharm D in quantitative pharmacology or pharmacometrics in pharmaceutical companies or CROs (titles determined by experience). Strong execution ability, independent scientific research capability, logical thinking, and coordination/problem-solving skills. Clear written and oral communication, good teamwork. Demonstrated expertise in QSP and popPK modeling with tools such as NONMEM, R, MATLAB, Monolix, etc. Deep understanding of PK/PD, translational medicine, and MIDD in clinical trials and drug development. Experience applying modeling and simulation to enable efficient preclinical and clinical development. Familiarity with regulatory requirements and guidelines for clinical pharmacology. Good project management and cross-functional collaboration skills. Proven scientific contributions through publications or presentations. Professional integrity and reliability. Benefits
We offer a best-in-class benefits package supporting well-being, financial stability, and long-term career growth. Highlights include medical, dental, and vision insurance, a 401(k) plan with company match, equity and stock options for eligible roles, paid parental leave, paid time off, holidays, and a range of other flexible benefits and wellness programs. EEO Statement
Legend Biotech is an equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law.
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