Eli Lilly and Company
Senior Scientist – Protein Purification
Eli Lilly and Company, Indianapolis, Indiana, us, 46262
Overview
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Senior Scientist – Protein Purification
role at
Eli Lilly and Company . Eli Lilly’s Biotechnology Discovery Research (BioTDR) organization has a track record of discovering, optimizing, and delivering novel biotherapeutic medicines to the clinic for unmet medical needs in diabetes, oncology, immunology, and neuroscience. This position is within the BioTDR Lead Optimization Group’s Protein Expression and Purification Team. The successful candidate will advance projects and emerging platforms in BioTDR and collaborate across the discovery organization to deliver Lilly’s early phase portfolio. The ideal candidate will have extensive hands-on experience with chromatography systems and a track record of purifying diverse proteins. Location: Indianapolis, Indiana. Travel: 0-10%.
Responsibilities
Design, develop, and execute protein purification strategies for diverse biotherapeutic modalities (e.g., monoclonal antibodies, multichain bispecific antibodies, Fab fragments, VHH, bioconjugates, etc.) and diverse reagent proteins.
Operate and maintain AKTA chromatography systems (e.g., AKTA Pure) for purification workflows from milligram to multi-gram scales.
Perform analytical characterization of purified proteins including purity assessment and concentration determination.
Influence the protein production workplans as an integral member of emerging biotherapeutic platform teams.
Basic Requirements
Master's degree in Biochemistry, Chemistry, Biology, or related field with 2+ years of relevant industry experience, OR Bachelor's degree in Biochemistry, Chemistry, Biology, or related field with 5+ years of relevant industry experience.
Proficiency with AKTA chromatography systems and hands-on experience purifying diverse modalities: monoclonal antibodies, Fab fragments, VHH, or other recombinant proteins.
Additional Skills/Preferences
Experience with multiple chromatography techniques (affinity, IEX, HIC, SEC).
Experience with bioconjugation of targeted lipid nanoparticles, including downstream purification and characterization.
Proficiency with UNICORN software.
Experience with automated liquid handling systems and high-throughput purification platforms.
Experience with protein analytical techniques such as SDS-PAGE, CE-SDS, cIEF, analytical HPLC, and related methods.
Experience with microbial and mammalian expression systems (HEK293, CHO) for production of milligram-to-gram scale proteins.
Experience with bioconjugation and/or targeted lipid nanoparticles.
Innovation in protein purification as demonstrated by a publication record.
Effective collaboration in a matrix environment with engineers, biochemists, biologists, and development scientists.
Strong verbal and written communication skills; ability to share learnings across team boundaries.
Excellent time management and organizational skills with the ability to adapt to changing priorities and deadlines.
Experience with Benchling electronic laboratory notebook and data analytics.
Commitment to safety and inclusion; coaching and mentoring peers and scientists.
Additional Information
Location: Indianapolis, Indiana
Travel: 0-10%
EEO and Benefits Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce. If you require accommodation to submit a resume, please complete the accommodation request form. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our compensation range for this role is provided below and may vary by location and experience.
Actual compensation will depend on education, experience, skills, and geographic location. The anticipated wage for this position is $65,250 - $169,400. Full-time employees may be eligible for a company bonus and Lilly offers a comprehensive benefits program including 401(k), health benefits, and well-being programs.
#WeAreLilly
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Join to apply for the
Senior Scientist – Protein Purification
role at
Eli Lilly and Company . Eli Lilly’s Biotechnology Discovery Research (BioTDR) organization has a track record of discovering, optimizing, and delivering novel biotherapeutic medicines to the clinic for unmet medical needs in diabetes, oncology, immunology, and neuroscience. This position is within the BioTDR Lead Optimization Group’s Protein Expression and Purification Team. The successful candidate will advance projects and emerging platforms in BioTDR and collaborate across the discovery organization to deliver Lilly’s early phase portfolio. The ideal candidate will have extensive hands-on experience with chromatography systems and a track record of purifying diverse proteins. Location: Indianapolis, Indiana. Travel: 0-10%.
Responsibilities
Design, develop, and execute protein purification strategies for diverse biotherapeutic modalities (e.g., monoclonal antibodies, multichain bispecific antibodies, Fab fragments, VHH, bioconjugates, etc.) and diverse reagent proteins.
Operate and maintain AKTA chromatography systems (e.g., AKTA Pure) for purification workflows from milligram to multi-gram scales.
Perform analytical characterization of purified proteins including purity assessment and concentration determination.
Influence the protein production workplans as an integral member of emerging biotherapeutic platform teams.
Basic Requirements
Master's degree in Biochemistry, Chemistry, Biology, or related field with 2+ years of relevant industry experience, OR Bachelor's degree in Biochemistry, Chemistry, Biology, or related field with 5+ years of relevant industry experience.
Proficiency with AKTA chromatography systems and hands-on experience purifying diverse modalities: monoclonal antibodies, Fab fragments, VHH, or other recombinant proteins.
Additional Skills/Preferences
Experience with multiple chromatography techniques (affinity, IEX, HIC, SEC).
Experience with bioconjugation of targeted lipid nanoparticles, including downstream purification and characterization.
Proficiency with UNICORN software.
Experience with automated liquid handling systems and high-throughput purification platforms.
Experience with protein analytical techniques such as SDS-PAGE, CE-SDS, cIEF, analytical HPLC, and related methods.
Experience with microbial and mammalian expression systems (HEK293, CHO) for production of milligram-to-gram scale proteins.
Experience with bioconjugation and/or targeted lipid nanoparticles.
Innovation in protein purification as demonstrated by a publication record.
Effective collaboration in a matrix environment with engineers, biochemists, biologists, and development scientists.
Strong verbal and written communication skills; ability to share learnings across team boundaries.
Excellent time management and organizational skills with the ability to adapt to changing priorities and deadlines.
Experience with Benchling electronic laboratory notebook and data analytics.
Commitment to safety and inclusion; coaching and mentoring peers and scientists.
Additional Information
Location: Indianapolis, Indiana
Travel: 0-10%
EEO and Benefits Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce. If you require accommodation to submit a resume, please complete the accommodation request form. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our compensation range for this role is provided below and may vary by location and experience.
Actual compensation will depend on education, experience, skills, and geographic location. The anticipated wage for this position is $65,250 - $169,400. Full-time employees may be eligible for a company bonus and Lilly offers a comprehensive benefits program including 401(k), health benefits, and well-being programs.
#WeAreLilly
#J-18808-Ljbffr