Nabla Bio
Overview
Protein Production & Developability Scientist at Nabla Bio. Send a CV and a statement of interest to hiring@nabla.bio. About Nabla Bio
Our mission is to generate new therapeutic opportunities by advancing AI and experimental technologies for drug design. Using AI and massively parallel experimentation, we design antibodies that precisely bind the disease target at the right location, while minimizing manufacturability and toxicity risks. We are a well-funded, revenue-generating, bilingual company of wet- and dry-lab scientists, and are founded by AI and protein design experts from Harvard University. Responsibilities
Develop high-throughput HEK and CHO-based antibody expression and purification Prioritize top development candidates by characterizing antibodies for key biophysical traits, including but not limited to, affinity, cross-reactivity, stability, polyspecificity, aggregation, and hydrophobicity Collaborate with dry-lab and wet-lab scientists to establish a rapid and seamless production and testing pipeline for characterizing machine learning generated antibody designs Qualifications
Bachelor’s or master’s degree, with 3+ years of antibody production and characterization experience in industry Proficiency in molecular biology and cloning of full-length antibodies and antibody fragments into mammalian expression vectors Extensive experience in HEK and CHO-based antibody expression at a variety of throughputs, including up to 96-well expression Experience with HEK and CHO-based antibody production at a variety of volumes, from mL to L scale Proficient in standard antibody purification approaches, with a track record of adapting these protocols or developing new ones for challenging antibodies Extensive experience in performing developability assessments on purified antibody, including assays such as DSF, SMAC, BLI/SPR, HIC, ELISA, among other standard biophysical characterization techniques Well-organized, and able to establish an operationally efficient antibody production and characterization pipeline that works reliably Problem-focused, and interested in working in a high-intensity, fast-paced environment often driven by deadlines Value unblocking colleagues, and are excited to mentor/train junior colleagues
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Protein Production & Developability Scientist at Nabla Bio. Send a CV and a statement of interest to hiring@nabla.bio. About Nabla Bio
Our mission is to generate new therapeutic opportunities by advancing AI and experimental technologies for drug design. Using AI and massively parallel experimentation, we design antibodies that precisely bind the disease target at the right location, while minimizing manufacturability and toxicity risks. We are a well-funded, revenue-generating, bilingual company of wet- and dry-lab scientists, and are founded by AI and protein design experts from Harvard University. Responsibilities
Develop high-throughput HEK and CHO-based antibody expression and purification Prioritize top development candidates by characterizing antibodies for key biophysical traits, including but not limited to, affinity, cross-reactivity, stability, polyspecificity, aggregation, and hydrophobicity Collaborate with dry-lab and wet-lab scientists to establish a rapid and seamless production and testing pipeline for characterizing machine learning generated antibody designs Qualifications
Bachelor’s or master’s degree, with 3+ years of antibody production and characterization experience in industry Proficiency in molecular biology and cloning of full-length antibodies and antibody fragments into mammalian expression vectors Extensive experience in HEK and CHO-based antibody expression at a variety of throughputs, including up to 96-well expression Experience with HEK and CHO-based antibody production at a variety of volumes, from mL to L scale Proficient in standard antibody purification approaches, with a track record of adapting these protocols or developing new ones for challenging antibodies Extensive experience in performing developability assessments on purified antibody, including assays such as DSF, SMAC, BLI/SPR, HIC, ELISA, among other standard biophysical characterization techniques Well-organized, and able to establish an operationally efficient antibody production and characterization pipeline that works reliably Problem-focused, and interested in working in a high-intensity, fast-paced environment often driven by deadlines Value unblocking colleagues, and are excited to mentor/train junior colleagues
#J-18808-Ljbffr