Prellis Biologics
Scientist/Senior Scientist - Bispecific Antibody Purification
Prellis Biologics, Berkeley, California, United States, 94709
Overview
Senior Scientist to join the Antibody Engineering Department, specializing in development of purification methods for bispecific and engineered antibody formats. Lead the development and optimization of purification workflows to support candidate screening, format characterization, and early-stage developability evaluations. Responsibilities
Develop and optimize purification methods for bispecific and engineered antibodies using Protein A, ion exchange (IEX), hydrophobic interaction chromatography (HIC), and size exclusion chromatography (SEC). Execute purification workflows using ÄKTA™ avant chromatography systems to support screening of antibody candidates from transient mammalian expression systems (e.g., HEK293, CHO). Implement and maintain high-throughput purification workflows to support early-stage format assessment and developability profiling. Perform protein characterization using SDS-PAGE and analytical SEC (for aggregation analysis). Conduct endotoxin testing on purified materials to ensure suitability for downstream applications, including in vitro and in vivo studies. Interface with Antibody Engineering scientists to evaluate purification behavior and developability risks of novel antibody constructs. Document all purification methods, experimental results, and analysis in electronic lab notebooks and technical reports. Qualifications
Ph.D. in Biochemistry, Chemical Engineering, Biotechnology, or related field with 3+ years of relevant industry experience; or M.S. with 8+ years in protein purification or biologics development. Extensive hands-on experience with purification of bispecific antibodies or other complex antibody modalities. Expertise using ÄKTA™ avant chromatography systems and Unicorn software for method development and optimization. Proficiency in chromatography techniques such as Protein A, IEX, SEC, and HIC. Experience with analytical tools including SDS-PAGE, analytical SEC, UV spectroscopy, and endotoxin measurement techniques (e.g., LAL assay, EndoSafe). Strong understanding of antibody structure and common developability challenges such as aggregation, mispairing, and heterogeneity. About Prellis Biologics
Prellis Biologics integrates human biology with machine learning to accelerate drug discovery. We aim to revolutionize antibody therapeutics by leveraging human immune repertoires and integrated ML to rapidly identify fully human antibody candidates. Prellis Biologics is a pre-IPO biotech based in Berkeley, CA, with a collaborative, inclusive culture and a growing pipeline across metabolic, inflammatory, and oncology therapeutic areas. We have raised funding from investors including Celesta, Khosla Ventures, SOSV, and Avidity Partners. What You Can Expect From Us
We support professional and personal growth and well-being through competitive benefits, a collaborative culture, and opportunities for career development. The salary range is posted for this role and may vary based on skills, experience, and qualifications. Benefits
In addition to base salary, Prellis offers benefits including health/dental/vision coverage, life and disability insurance, flexible spending accounts, a 401(k) plan, stock-based incentives, bonus plan, holiday time, and flexible work models where possible. Application and Equal Opportunity
Prellis does not have an application deadline for this position; applications will be accepted until a suitable candidate is selected. Prellis Bio is an equal opportunity employer. All applicants will be considered without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. We are committed to diversity, equity, and inclusion and strive to ensure equitable treatment throughout the interview process.
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Senior Scientist to join the Antibody Engineering Department, specializing in development of purification methods for bispecific and engineered antibody formats. Lead the development and optimization of purification workflows to support candidate screening, format characterization, and early-stage developability evaluations. Responsibilities
Develop and optimize purification methods for bispecific and engineered antibodies using Protein A, ion exchange (IEX), hydrophobic interaction chromatography (HIC), and size exclusion chromatography (SEC). Execute purification workflows using ÄKTA™ avant chromatography systems to support screening of antibody candidates from transient mammalian expression systems (e.g., HEK293, CHO). Implement and maintain high-throughput purification workflows to support early-stage format assessment and developability profiling. Perform protein characterization using SDS-PAGE and analytical SEC (for aggregation analysis). Conduct endotoxin testing on purified materials to ensure suitability for downstream applications, including in vitro and in vivo studies. Interface with Antibody Engineering scientists to evaluate purification behavior and developability risks of novel antibody constructs. Document all purification methods, experimental results, and analysis in electronic lab notebooks and technical reports. Qualifications
Ph.D. in Biochemistry, Chemical Engineering, Biotechnology, or related field with 3+ years of relevant industry experience; or M.S. with 8+ years in protein purification or biologics development. Extensive hands-on experience with purification of bispecific antibodies or other complex antibody modalities. Expertise using ÄKTA™ avant chromatography systems and Unicorn software for method development and optimization. Proficiency in chromatography techniques such as Protein A, IEX, SEC, and HIC. Experience with analytical tools including SDS-PAGE, analytical SEC, UV spectroscopy, and endotoxin measurement techniques (e.g., LAL assay, EndoSafe). Strong understanding of antibody structure and common developability challenges such as aggregation, mispairing, and heterogeneity. About Prellis Biologics
Prellis Biologics integrates human biology with machine learning to accelerate drug discovery. We aim to revolutionize antibody therapeutics by leveraging human immune repertoires and integrated ML to rapidly identify fully human antibody candidates. Prellis Biologics is a pre-IPO biotech based in Berkeley, CA, with a collaborative, inclusive culture and a growing pipeline across metabolic, inflammatory, and oncology therapeutic areas. We have raised funding from investors including Celesta, Khosla Ventures, SOSV, and Avidity Partners. What You Can Expect From Us
We support professional and personal growth and well-being through competitive benefits, a collaborative culture, and opportunities for career development. The salary range is posted for this role and may vary based on skills, experience, and qualifications. Benefits
In addition to base salary, Prellis offers benefits including health/dental/vision coverage, life and disability insurance, flexible spending accounts, a 401(k) plan, stock-based incentives, bonus plan, holiday time, and flexible work models where possible. Application and Equal Opportunity
Prellis does not have an application deadline for this position; applications will be accepted until a suitable candidate is selected. Prellis Bio is an equal opportunity employer. All applicants will be considered without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. We are committed to diversity, equity, and inclusion and strive to ensure equitable treatment throughout the interview process.
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