Society for Neuroscience
Post-Doctoral Fellowship - Neuronal Regulation of Energy Metabolism
Society for Neuroscience, Baltimore, Maryland, United States, 21276
Overview
Post-Doctoral Fellowship - Neuronal Regulation of Energy Metabolism The laboratory of Matthew Poy in the Johns Hopkins University School of Medicine is seeking two post‑doctoral fellows for a project on the neuronal regulation of energy metabolism. Projects are based on recent lab publications and are tailored to the background of each candidate. Specific topics include (1) RNAi in neurodegenerative disorders, (2) sympathetic innervation and energy metabolism, and (3) neuro‑immune cell interface in diabetes/obesity. The metabolic syndrome is characterized by obesity, hyperglycemia, and insulin resistance and alterations to both insulin and leptin signaling cascades can contribute to a pathogenic state. Previous studies by our group have shown that microRNAs are highly regulated in the pancreatic islets of insulin‑resistant mouse models and in the islets of type 2 diabetic human subjects and play a key role in the growth and function of the pancreatic beta cell. Many of the genes targeted by microRNAs in the endocrine pancreas are abundantly expressed in the CNS, suggesting these factors serve in a similar capacity across multiple tissues. In addition, the susceptibility to obesity is linked to genes regulating neurotransmission, pancreatic beta‑cell function and energy homeostasis and we recently characterized the role of CADM1 and CADM2 in the regulation of body weight. Future aims are directed towards understanding the role of the microRNA pathway in the CNS in managing systemic energy metabolism and metabolic stress responses as well as elucidating its specific mechanisms of action. Responsibilities
Plan and execute experimental research independently and collaborate with team members to advance projects on neuronal regulation of energy metabolism. Engage in studies related to RNAi in neurodegenerative disorders, sympathetic innervation and energy metabolism, and neuro‑immune cell interfaces in diabetes/obesity. Maintain meticulous records, organize data, and contribute to manuscript preparation and presentations. Qualifications
Ph.D. in a relevant subject (e.g., Molecular Biology, Biochemistry, Physiology, or Genetics). Publication history and demonstrated ability to conduct independent research. Excellent organization and record‑keeping skills; meticulous approach to practical work. Ability to work effectively and flexibly as part of a team and to plan and execute experimental research independently. CV, a cover letter describing career goals, and contact information for at least two referees to mpoy1@jhmi.edu. Details
Employer: Johns Hopkins University School of Medicine Location: Baltimore, Maryland Salary: According to NIH scale and prior experience Closing date: Oct 22, 2025
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Post-Doctoral Fellowship - Neuronal Regulation of Energy Metabolism The laboratory of Matthew Poy in the Johns Hopkins University School of Medicine is seeking two post‑doctoral fellows for a project on the neuronal regulation of energy metabolism. Projects are based on recent lab publications and are tailored to the background of each candidate. Specific topics include (1) RNAi in neurodegenerative disorders, (2) sympathetic innervation and energy metabolism, and (3) neuro‑immune cell interface in diabetes/obesity. The metabolic syndrome is characterized by obesity, hyperglycemia, and insulin resistance and alterations to both insulin and leptin signaling cascades can contribute to a pathogenic state. Previous studies by our group have shown that microRNAs are highly regulated in the pancreatic islets of insulin‑resistant mouse models and in the islets of type 2 diabetic human subjects and play a key role in the growth and function of the pancreatic beta cell. Many of the genes targeted by microRNAs in the endocrine pancreas are abundantly expressed in the CNS, suggesting these factors serve in a similar capacity across multiple tissues. In addition, the susceptibility to obesity is linked to genes regulating neurotransmission, pancreatic beta‑cell function and energy homeostasis and we recently characterized the role of CADM1 and CADM2 in the regulation of body weight. Future aims are directed towards understanding the role of the microRNA pathway in the CNS in managing systemic energy metabolism and metabolic stress responses as well as elucidating its specific mechanisms of action. Responsibilities
Plan and execute experimental research independently and collaborate with team members to advance projects on neuronal regulation of energy metabolism. Engage in studies related to RNAi in neurodegenerative disorders, sympathetic innervation and energy metabolism, and neuro‑immune cell interfaces in diabetes/obesity. Maintain meticulous records, organize data, and contribute to manuscript preparation and presentations. Qualifications
Ph.D. in a relevant subject (e.g., Molecular Biology, Biochemistry, Physiology, or Genetics). Publication history and demonstrated ability to conduct independent research. Excellent organization and record‑keeping skills; meticulous approach to practical work. Ability to work effectively and flexibly as part of a team and to plan and execute experimental research independently. CV, a cover letter describing career goals, and contact information for at least two referees to mpoy1@jhmi.edu. Details
Employer: Johns Hopkins University School of Medicine Location: Baltimore, Maryland Salary: According to NIH scale and prior experience Closing date: Oct 22, 2025
#J-18808-Ljbffr