BioSpace
Research Associate - Antibody Discovery and Development
BioSpace, South San Francisco, California, us, 94083
Overview
Research Associate - Antibody Discovery and Development at TegMine Therapeutics. We are on a mission to restore futures cut short by cancer. Our advanced O-glycoproteomics platform is pioneering the next generation of cancer-specific therapeutic targets, and we are dedicated to delivering best-in-class therapies for currently untreatable diseases. We are seeking a highly motivated and skilled Research Associate to join our dynamic team. In this role, you will be instrumental in designing, developing, and optimizing the processes we use to produce therapeutic antibodies. This hands-on laboratory position focuses on protein expression, purification, and biochemical characterization, supporting our therapeutic pipeline from discovery through the early preclinical stages. Responsibilities
Protein Expression: Express recombinant antibodies through transient and stable transfections in mammalian cell lines (e.g., CHO, HEK293). Protein Purification: Develop and execute multi-step purification strategies using chromatography systems (e.g., ÄKTA), employing techniques like Protein A affinity, ion-exchange (IEX), and size-exclusion chromatography (SEC). Biochemical & Biophysical Characterization: Characterize purified antibodies using analytical methods such as SDS-PAGE, Western Blot, flow cytometry, ELISA, internalization, in vitro killing, kinetics analysis, HPLC, and UV-Vis spectrophotometry. Data Analysis & Documentation: Document all experimental procedures and results in an electronic lab notebook (ELN). Analyze, interpret, and present data clearly to the project team. Process Optimization: Help develop and refine robust, scalable processes for antibody production and purification, proactively identifying and troubleshooting issues. Qualifications
Master’s degree in Molecular Biology, Biochemistry, Biotechnology, or a related field with 2+ years of industry experience, OR a Bachelor’s degree with 4+ years of industry experience. Technical Skills: Proficient in mammalian cell culture and aseptic techniques. Demonstrated expertise in protein purification using chromatography systems. Familiarity with standard analytical techniques for protein characterization (e.g., SDS-PAGE, HPLC, flow cytometry, ELISA). Personal Attributes: Excellent problem-solving, organizational, and time-management skills. Collaborative spirit with the ability to work effectively independently and in a team. Clear and effective written and verbal communication skills. We Provide a Comprehensive Compensation And Benefits Package
Equity in a promising start-up Comprehensive health coverage 401k & paid time off Significant opportunities for professional growth and development If you’re passionate about innovation, thrive in a collaborative environment, and want to make a real impact, we’d love to hear from you! TegMine is an equal opportunity employer and does not discriminate based on any legally protected status. To apply, please email futures@tegminetx.com. Location: San Francisco, CA and Menlo Park, CA
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Research Associate - Antibody Discovery and Development at TegMine Therapeutics. We are on a mission to restore futures cut short by cancer. Our advanced O-glycoproteomics platform is pioneering the next generation of cancer-specific therapeutic targets, and we are dedicated to delivering best-in-class therapies for currently untreatable diseases. We are seeking a highly motivated and skilled Research Associate to join our dynamic team. In this role, you will be instrumental in designing, developing, and optimizing the processes we use to produce therapeutic antibodies. This hands-on laboratory position focuses on protein expression, purification, and biochemical characterization, supporting our therapeutic pipeline from discovery through the early preclinical stages. Responsibilities
Protein Expression: Express recombinant antibodies through transient and stable transfections in mammalian cell lines (e.g., CHO, HEK293). Protein Purification: Develop and execute multi-step purification strategies using chromatography systems (e.g., ÄKTA), employing techniques like Protein A affinity, ion-exchange (IEX), and size-exclusion chromatography (SEC). Biochemical & Biophysical Characterization: Characterize purified antibodies using analytical methods such as SDS-PAGE, Western Blot, flow cytometry, ELISA, internalization, in vitro killing, kinetics analysis, HPLC, and UV-Vis spectrophotometry. Data Analysis & Documentation: Document all experimental procedures and results in an electronic lab notebook (ELN). Analyze, interpret, and present data clearly to the project team. Process Optimization: Help develop and refine robust, scalable processes for antibody production and purification, proactively identifying and troubleshooting issues. Qualifications
Master’s degree in Molecular Biology, Biochemistry, Biotechnology, or a related field with 2+ years of industry experience, OR a Bachelor’s degree with 4+ years of industry experience. Technical Skills: Proficient in mammalian cell culture and aseptic techniques. Demonstrated expertise in protein purification using chromatography systems. Familiarity with standard analytical techniques for protein characterization (e.g., SDS-PAGE, HPLC, flow cytometry, ELISA). Personal Attributes: Excellent problem-solving, organizational, and time-management skills. Collaborative spirit with the ability to work effectively independently and in a team. Clear and effective written and verbal communication skills. We Provide a Comprehensive Compensation And Benefits Package
Equity in a promising start-up Comprehensive health coverage 401k & paid time off Significant opportunities for professional growth and development If you’re passionate about innovation, thrive in a collaborative environment, and want to make a real impact, we’d love to hear from you! TegMine is an equal opportunity employer and does not discriminate based on any legally protected status. To apply, please email futures@tegminetx.com. Location: San Francisco, CA and Menlo Park, CA
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