Prime Medicine, Inc.
Scientist/Senior Scientist, LNP Discovery
Prime Medicine, Inc., Cambridge, Massachusetts, us, 02140
Overview
Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies. The Company leverages its proprietary Prime Editing platform to develop a new class of one-time, potentially curative genetic therapies designed to make the right edit at the right position while minimizing unwanted DNA modifications. Prime Editors have the potential to repair many genetic mutations across various tissues and cell types. Prime Medicine is progressing a diversified portfolio of investigational therapeutic programs in hematology, immunology & oncology, liver and lung. Each core area focuses on high-value programs with clear clinical development and regulatory paths, providing a foundation for future expansion. For more information, please visit www.primemedicine.com. Position Overview We are seeking a Scientist/Senior Scientist with expertise in lipid nanoparticle (LNP) formulation and application of LNPs to mouse models to join our LNP Discovery team focused on developing non-viral delivery systems for cystic fibrosis therapies. This role involves designing and characterizing LNPs for in vivo delivery of Prime Editor RNA molecules, with hands-on in vivo work in pulmonary delivery studies. The role offers opportunities across the full spectrum of LNP development, from formulation to in vivo delivery, within a collaborative cross-functional program team. We are looking for curious problem solvers who thrive on fast-paced, exciting projects and are passionate about developing genetic editing technologies to improve human health. The ideal candidate will be onsite five days a week in Cambridge, MA. Primary Responsibilities
Design and formulate LNPs using microfluidics; characterize using DLS, zeta potential, pKa, and Ribogreen assays. Execute and support in vivo studies focused on pulmonary delivery of LNP formulations, including intratracheal delivery in preclinical models. Collaborate with internal teams on study design, execution, data collection, and interpretation. Support downstream analyses using flow cytometry and molecular biology techniques. Collaborate cross-functionally to integrate in vivo findings into delivery platform development. Present data in written reports and oral presentations. Qualifications
PhD in Biomedical/Chemical Engineering, Biochemistry, or related field with 0-2 years of relevant experience (or BS+8, MS+6). Experience with lipid nanoparticle (LNP) formulation, QC, and characterization techniques. Hands-on experience with mouse handling, dosing, and tissue collection; intratracheal delivery strongly preferred. Familiarity with molecular biology techniques (e.g., qPCR, DNA sequencing, mammalian cell culture, and flow cytometry). Strong organizational and critical thinking skills, attention to detail, and ability to work independently and in a team. Excellent communication and interpersonal skills to thrive in a cross-functional setting. Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.
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Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies. The Company leverages its proprietary Prime Editing platform to develop a new class of one-time, potentially curative genetic therapies designed to make the right edit at the right position while minimizing unwanted DNA modifications. Prime Editors have the potential to repair many genetic mutations across various tissues and cell types. Prime Medicine is progressing a diversified portfolio of investigational therapeutic programs in hematology, immunology & oncology, liver and lung. Each core area focuses on high-value programs with clear clinical development and regulatory paths, providing a foundation for future expansion. For more information, please visit www.primemedicine.com. Position Overview We are seeking a Scientist/Senior Scientist with expertise in lipid nanoparticle (LNP) formulation and application of LNPs to mouse models to join our LNP Discovery team focused on developing non-viral delivery systems for cystic fibrosis therapies. This role involves designing and characterizing LNPs for in vivo delivery of Prime Editor RNA molecules, with hands-on in vivo work in pulmonary delivery studies. The role offers opportunities across the full spectrum of LNP development, from formulation to in vivo delivery, within a collaborative cross-functional program team. We are looking for curious problem solvers who thrive on fast-paced, exciting projects and are passionate about developing genetic editing technologies to improve human health. The ideal candidate will be onsite five days a week in Cambridge, MA. Primary Responsibilities
Design and formulate LNPs using microfluidics; characterize using DLS, zeta potential, pKa, and Ribogreen assays. Execute and support in vivo studies focused on pulmonary delivery of LNP formulations, including intratracheal delivery in preclinical models. Collaborate with internal teams on study design, execution, data collection, and interpretation. Support downstream analyses using flow cytometry and molecular biology techniques. Collaborate cross-functionally to integrate in vivo findings into delivery platform development. Present data in written reports and oral presentations. Qualifications
PhD in Biomedical/Chemical Engineering, Biochemistry, or related field with 0-2 years of relevant experience (or BS+8, MS+6). Experience with lipid nanoparticle (LNP) formulation, QC, and characterization techniques. Hands-on experience with mouse handling, dosing, and tissue collection; intratracheal delivery strongly preferred. Familiarity with molecular biology techniques (e.g., qPCR, DNA sequencing, mammalian cell culture, and flow cytometry). Strong organizational and critical thinking skills, attention to detail, and ability to work independently and in a team. Excellent communication and interpersonal skills to thrive in a cross-functional setting. Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.
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