Associate Staff Scientist

**UAMS offers amazing benefits and perks** (available for benefits eligible positions only):* Health: Medical, Dental and Vision plans available for qualifying staff and family* Holiday, Vacation and Sick Leave* Education discount for staff and dependents (undergraduate only)* Retirement: Up to 10% matched contribution from UAMS* Basic Life Insurance up to $50,000* Career Training and Educational Opportunities* Merchant Discounts* Concierge prescription delivery on the main campus when using UAMS pharmacy* Ph.D. in Bioscience, Biochemistry, Structural Biology, or a related **PLUS** five (5) years of laboratory experience in structural biology, including both X-ray crystallography and cryo-EM* Demonstrated expertise in “gene-to-structure” determination, including protein expression, purification, crystallization, and structure analysis* Proven record of successful cryo-EM structure determination supported by peer-reviewed publications or scientific presentations* Experience with bacterial protein expression and purification* Proficiency with structural biology software such as RELION, CryoSPARC, Phenix, CCP4, and Coot* Strong understanding of protein biochemistry, molecular biology, and macromolecular structure-function relationships* Experience with Linux-based computational environments for data analysis and modeling* Ability to troubleshoot complex experimental and computational workflows* Excellent organizational, communication, and documentation skills* Demonstrated ability to work both independently and collaboratively in a multidisciplinary research setting* Commitment to maintaining safety, data integrity, and scientific rigor in all laboratory activities* Experience expressing and purifying proteins using mammalian, yeast, or insect cell systems* Experience assisting and mentoring scientists in structure determination by cryo-EM and/or X-ray crystallography* Strong collaborative and problem-solving skills* Conduct structural biology research using cryo-electron microscopy (cryo-EM) and X-ray crystallography.* Prepare and freeze grids, evaluate samples by negative stain and cryo-EM, and collect high-resolution cryo-EM data.* Perform particle selection, classification, and structure refinement to determine and finalize coordinate structures.* Conduct crystallization screening, crystal optimization, X-ray diffraction data collection, structure solution, and refinement.* Prepare and purify samples for analysis by cryo-EM and X-ray crystallography.* Train students, postdoctoral fellows, and scientists in structural biology techniques.* Supervise laboratory staff and ensure compliance with all University, State, and Federal safety regulations.* Maintain and operate laboratory equipment including FEI Vitrobot, Leica GP2, Mosquito crystallization robot, and Formulatrix plate hotel.* Manage inventory, order supplies, and track equipment service and maintenance schedules.* Supervise and support personnel in developing new laboratory protocols.* Collaborate with faculty, students, and postdoctoral fellows to advance research projects.* Work independently while maintaining consistent communication with the Principal Investigator.* Perform additional duties as assigned.At the University of Arkansas for Medical Sciences (UAMS), we are looking for health care and non-health care professionals who believe in excellence as a way of life. If you think you have the skills and commitment to succeed at the highest level, consider a career at UAMS, the state’s only academic health sciences center. Combining diverse talents and expertise, our employees work together to provide advanced patient care.We currently have a wide variety of positions available, from patient care to support staff- we may have the perfect position for you.UAMS rewards its nurses! Statewide opportunities are available in direct patient care, education, and research settings.

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