postdoctoral position, Bethesda, MD

Jobs in Structural Biology and Related Fields

postdoctoral position, Bethesda, MD

Bethesda, United States A

postdoctoral position

is available

immediately

in the

Pazgier Laboratory

at the Uniformed Services University of the Health Sciences (USU) in

Bethesda, MD . They are seeking a highly motivated and skilled

postdoctoral fellow

with expertise in both

immunology

and

structural biology

to participate in an interdisciplinary research program focused on

structural immunology using X-Ray crystallography/Cryo-EM and Cryo-ET . Research Focus The successful candidate will contribute to ongoing projects aimed at elucidating Fc-effector mechanisms of the

adaptive immune response (including IgG and IgA) to HIV-1

with the ultimate goal of identify effective strategies to preserve immune function and promote healthy aging. Projects will leverage high-resolution structural methods to dissect the interactions between antibodies, viral proteins, and Fc receptors, and will integrate structural data with functional immunological assays. Required Qualifications A

Ph.D. in immunology , structural biology, biochemistry, molecular biology, or a closely related field. Demonstrated expertise in

X-Ray-crystallography,

Cryo-Electron Microscopy (Cryo-EM)

and/or

Cryo-Electron Tomography (Cryo-ET)

for structural determination. Solid understanding of human

immune response , particularly B cell responses, antibodies, Fc receptors, and antigen-antibody interactions. Strong technical skills in

molecular cloning ,

protein expression and purification , and

molecular interaction analysis

(e.g., SPR, BLI). A strong track record of

peer-reviewed publications . Excellent interpersonal, organizational, and communication skills (oral and written). A collaborative, team-oriented mindset and enthusiasm for interdisciplinary research. Preferred Qualifications Experience with

hybrid approaches

that integrate Cryo-EM/cryo-ET with

X-ray crystallography ,

computational modeling Experience in

antibody engineering

or

Fc-effector function assays

(ADCC, ADCP). Familiarity with

immune repertoire analysis ,

epitope mapping , or

systems serology

approaches. Why Join Them? USU is located

directly across from the NIH campus in Bethesda , placing it in the heart of one of the most vibrant biomedical research communities in the world. Their lab benefits from access to outstanding

core facilities , including those for

Next-Generation Sequencing ,

Cryo-EM ,

Bioinformatics , and

High-Performance Computing . USU offers a

strongly collaborative environment , with weekly

Immunology data clubs ,

journal clubs , and frequent

research seminars

featuring both local and international speakers. They welcome applicants at all career stages who are excited to work in a

multidisciplinary

and

translational

environment.

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