Itlearn360
Senior Scientist - Antibody Discovery at Systimmune Redmond, WA
Itlearn360, Redmond, Washington, United States, 98052
Overview
Senior Scientist - Antibody Discovery at SystImmune, Redmond, WA. SystImmune is a leading, well-funded clinical-stage biopharmaceutical company focused on developing innovative cancer treatments using bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). The company has assets in various stages of clinical trials for solid tumor and hematologic indications and a robust preclinical pipeline in discovery and IND-enabling stages. This role offers the opportunity to learn and contribute to cutting-edge biologics development within a dynamic team. Responsibilities
Perform in-depth analysis of potential targets, including clinical landscape, biology, protein structure, and literature review. Design and execute antibody discovery campaigns from immunization to lead delivery. Perform high-throughput sorting to isolate specific B cell populations. Design, execute, and analyze FACS experiments to validate and characterize antibodies. Develop, optimize, and perform assays (ELISA, BLI, flow cytometry) for antibody screening and specificity testing. Conduct yeast display library screening to identify and analyze antibody candidates. Analyze and compare BCR sequences and immune repertoires. Analyze experimental data and prepare detailed reports and presentations. Work with cross-functional teams and contribute to project planning and strategy. Maintain accurate records, ensure safety compliance, and contribute to lab organization. Qualifications
Ph.D. in Immunology, Molecular Biology, Biochemistry, or a related field. 3+ years of hands-on experience in B-cell sorting and screening through flow cytometry, ELISA and bio-layer interferometry. 3+ years of hands-on experience in yeast library preparation, culture, and screening. Knowledge of antibody structure; general knowledge of structural biology is a plus. Extensive knowledge of B-cell immunology and antibody development. Extensive knowledge of cancer immunology. Proven contribution to therapeutic antibody development is highly desirable. Experience in NGS library preparation and BCR repertoire analysis is desirable. Technical Skills
Proficiency in flow cytometry and cell sorting techniques. Experience in biolayer interferometry (affinity, avidity, binning) or similar assays. Strong background in ELISA assay development and optimization. Expertise in molecular biology techniques related to yeast display libraries. Familiarity with data analysis software and statistical tools (e.g., FlowJo, OCTET, GraphPad Prism, Geneious Prime). Soft Skills
Excellent problem-solving and troubleshooting abilities. Strong organizational and time management skills. Ability to work independently and as part of a team. Effective communication skills, both written and verbal. Work Environment
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. The individual will work in a molecular biology laboratory alongside other scientists and in a standard business office with desktop equipment and a moderate noise level. Physical Demands
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. While performing the duties of this job, the employee is regularly required to sit for long periods and operate standard laboratory and business equipment. Compensation and Benefits
The expected base salary range for this position is $90,000 - $140,000 annually. Actual compensation will be based on a variety of factors, including the candidate’s qualifications, experience, and skills. Offers may fall at the low to mid-point or higher for exceptional candidates depending on fit. SystImmune offers a comprehensive benefits package including 100% paid employee premiums for medical/dental/vision, STD, LTD, a 401(k) plan with 50% company match up to 3% and a 5-year vesting schedule, 15 PTO days per year, sick leave, and 11 paid holidays. Equal Opportunity Employer
SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.
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Senior Scientist - Antibody Discovery at SystImmune, Redmond, WA. SystImmune is a leading, well-funded clinical-stage biopharmaceutical company focused on developing innovative cancer treatments using bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). The company has assets in various stages of clinical trials for solid tumor and hematologic indications and a robust preclinical pipeline in discovery and IND-enabling stages. This role offers the opportunity to learn and contribute to cutting-edge biologics development within a dynamic team. Responsibilities
Perform in-depth analysis of potential targets, including clinical landscape, biology, protein structure, and literature review. Design and execute antibody discovery campaigns from immunization to lead delivery. Perform high-throughput sorting to isolate specific B cell populations. Design, execute, and analyze FACS experiments to validate and characterize antibodies. Develop, optimize, and perform assays (ELISA, BLI, flow cytometry) for antibody screening and specificity testing. Conduct yeast display library screening to identify and analyze antibody candidates. Analyze and compare BCR sequences and immune repertoires. Analyze experimental data and prepare detailed reports and presentations. Work with cross-functional teams and contribute to project planning and strategy. Maintain accurate records, ensure safety compliance, and contribute to lab organization. Qualifications
Ph.D. in Immunology, Molecular Biology, Biochemistry, or a related field. 3+ years of hands-on experience in B-cell sorting and screening through flow cytometry, ELISA and bio-layer interferometry. 3+ years of hands-on experience in yeast library preparation, culture, and screening. Knowledge of antibody structure; general knowledge of structural biology is a plus. Extensive knowledge of B-cell immunology and antibody development. Extensive knowledge of cancer immunology. Proven contribution to therapeutic antibody development is highly desirable. Experience in NGS library preparation and BCR repertoire analysis is desirable. Technical Skills
Proficiency in flow cytometry and cell sorting techniques. Experience in biolayer interferometry (affinity, avidity, binning) or similar assays. Strong background in ELISA assay development and optimization. Expertise in molecular biology techniques related to yeast display libraries. Familiarity with data analysis software and statistical tools (e.g., FlowJo, OCTET, GraphPad Prism, Geneious Prime). Soft Skills
Excellent problem-solving and troubleshooting abilities. Strong organizational and time management skills. Ability to work independently and as part of a team. Effective communication skills, both written and verbal. Work Environment
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. The individual will work in a molecular biology laboratory alongside other scientists and in a standard business office with desktop equipment and a moderate noise level. Physical Demands
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. While performing the duties of this job, the employee is regularly required to sit for long periods and operate standard laboratory and business equipment. Compensation and Benefits
The expected base salary range for this position is $90,000 - $140,000 annually. Actual compensation will be based on a variety of factors, including the candidate’s qualifications, experience, and skills. Offers may fall at the low to mid-point or higher for exceptional candidates depending on fit. SystImmune offers a comprehensive benefits package including 100% paid employee premiums for medical/dental/vision, STD, LTD, a 401(k) plan with 50% company match up to 3% and a 5-year vesting schedule, 15 PTO days per year, sick leave, and 11 paid holidays. Equal Opportunity Employer
SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.
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