Endless Health
LC-MS/MS Scientist (MS/PhD Preferred)
Location:
Austin, TX |
Type:
Full-time |
On-site
Salary range:
$65,000 – $100,000 USD per year (depending on experience)
Equity options
included
About EndlessDx Laboratory At
EndlessDx , we’re building a clinical lab that marries analytical rigor with real-world impact. We’re CLIA/CAP‑accredited and laser‑focused on delivering
high‑quality LC‑MS/MS assays
for clinical programs that can change how preventive and precision medicine reach patients.
We’re a small, fast‑moving team that values
deep technical mastery , clean data, and smart, practical science. If you love developing robust methods and want your work to power actual patient care—not sit on a shelf—this is the place.
What You’ll Do
Develop, optimize, and validate
quantitative LC‑MS/MS methods (triple quadrupole) to CLIA/CAP standards.
Own sample prep workflows
(PP, LLE, SPE; steroid derivatization) for serum/plasma and DBS/card matrices.
Run and maintain
SCIEX 7500+ and UHPLC systems, troubleshooting real issues like suppression, interferences, and carryover.
Write and execute
validation plans, SOPs, and study reports; ensure complete data integrity and traceability through LIMS.
Mentor and train junior analysts , helping to raise the collective bar on analytical science in the lab.
What You Bring
MS or PhD
in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related fields (BS with strong experience considered).
2–5+ years hands‑on LC‑MS/MS
experience in regulated clinical or bioanalytical environments.
A proven track record in
quantitative assay development
on triple quads—stable isotope IS use, calibration/QC strategy, clean data under pressure.
A
builder’s mindset : you care about scientific rigor, but you’re also practical and love seeing your assays go live.
Bonus Points For
Experience with
hormone/steroid panels , PFAS, or biomarker assays.
DBS workflows
expertise (e.g., hematocrit/matrix effect mitigation).
Exposure to
CLIA/CAP inspections , CLSI guidelines, or other regulated validation frameworks.
Why This Role Matters Our LC‑MS/MS lab is the beating heart of how we deliver precision diagnostics at scale. The methods you build will
directly power clinical programs , sometimes weeks after you validate them. You’ll get to shape both the science and the systems in a modern, well‑equipped lab—working alongside a small, sharp team that moves fast and sweats the details.
We offer
meaningful equity
because we want our early team members to share in the upside of building something important and enduring.
How to Apply Interested?
Apply via LinkedIn with a statement of interest at the top of your CV (Why are you interested in this role at Endless?) or email your CV with that statement directly to
wenli@endless.health . If you’re the kind of scientist who lights up talking about signal suppression or calibration curve residuals, we should talk.
#J-18808-Ljbffr
Austin, TX |
Type:
Full-time |
On-site
Salary range:
$65,000 – $100,000 USD per year (depending on experience)
Equity options
included
About EndlessDx Laboratory At
EndlessDx , we’re building a clinical lab that marries analytical rigor with real-world impact. We’re CLIA/CAP‑accredited and laser‑focused on delivering
high‑quality LC‑MS/MS assays
for clinical programs that can change how preventive and precision medicine reach patients.
We’re a small, fast‑moving team that values
deep technical mastery , clean data, and smart, practical science. If you love developing robust methods and want your work to power actual patient care—not sit on a shelf—this is the place.
What You’ll Do
Develop, optimize, and validate
quantitative LC‑MS/MS methods (triple quadrupole) to CLIA/CAP standards.
Own sample prep workflows
(PP, LLE, SPE; steroid derivatization) for serum/plasma and DBS/card matrices.
Run and maintain
SCIEX 7500+ and UHPLC systems, troubleshooting real issues like suppression, interferences, and carryover.
Write and execute
validation plans, SOPs, and study reports; ensure complete data integrity and traceability through LIMS.
Mentor and train junior analysts , helping to raise the collective bar on analytical science in the lab.
What You Bring
MS or PhD
in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related fields (BS with strong experience considered).
2–5+ years hands‑on LC‑MS/MS
experience in regulated clinical or bioanalytical environments.
A proven track record in
quantitative assay development
on triple quads—stable isotope IS use, calibration/QC strategy, clean data under pressure.
A
builder’s mindset : you care about scientific rigor, but you’re also practical and love seeing your assays go live.
Bonus Points For
Experience with
hormone/steroid panels , PFAS, or biomarker assays.
DBS workflows
expertise (e.g., hematocrit/matrix effect mitigation).
Exposure to
CLIA/CAP inspections , CLSI guidelines, or other regulated validation frameworks.
Why This Role Matters Our LC‑MS/MS lab is the beating heart of how we deliver precision diagnostics at scale. The methods you build will
directly power clinical programs , sometimes weeks after you validate them. You’ll get to shape both the science and the systems in a modern, well‑equipped lab—working alongside a small, sharp team that moves fast and sweats the details.
We offer
meaningful equity
because we want our early team members to share in the upside of building something important and enduring.
How to Apply Interested?
Apply via LinkedIn with a statement of interest at the top of your CV (Why are you interested in this role at Endless?) or email your CV with that statement directly to
wenli@endless.health . If you’re the kind of scientist who lights up talking about signal suppression or calibration curve residuals, we should talk.
#J-18808-Ljbffr