Bench Scientist

A rare position is available for a bioanalytical scientist to join a state-of-the-art protein mass spectrometry laboratory lab in Pharmaceutical's Pharmacokinetics Dynamics and Metabolism department. The lab based role will focus on the development of a Client type of sensitive quantitative assay to characterize and quantify the effect of anti-drug antibodies against protein bio therapeutics in the context of unwanted immunogenicity. This position requires expertise in bioanalytical procedures including immunoanalytical workflows, solid background in protein biochemistry, and ideally expertise in triple quadrupole quantitative mass spectrometry. The candidate will participate in all phases of mass spec laboratory operations including the development of sample preparation methods, assay execution, instrument maintenance and data analysis/reporting. We are looking for a scientist passionate about learning and quickly applying new skills to the project needs. Additional Skills: Apply existing protein quantitation workflows using bead and column based immunoaffinity enrichment including the use of liquid handling robotics. Run bioanalytical assays under minimal supervision; initiative in method development is expected. Independent daily operation, calibration, maintenance, and trouble shooting of multi-dimensional nanoflow liquid chromatography and nanospray triple quadrupole mass spectrometry instrumentation. Support analysis of quantitative LC-MS/MS data using relevant bioinformatics and quantitation software. Additional Information

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