Merck
Principal Scientist, Drug Metabolism and Pharmacokinetics (REMOTE)
Merck, West Point, Pennsylvania, us, 19486
Principal Scientist, Drug Metabolism and Pharmacokinetics (REMOTE)
2 days ago Be among the first 25 applicants
The remote position is for applicants not within commutable distance to primary sites noted in the posting. The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) function of our Research & Development Division in West Point, Pennsylvania, is seeking a dynamic and collaborative scientist for the Drug Metabolism and Pharmacokinetics (DMPK) group. The Principal Scientist will contribute to multi-disciplinary drug development and discovery efforts, providing an integrated understanding of DMPK properties, pharmacokinetics/pharmacodynamics (PK/PD), and drug interaction (DDI) risk of novel therapeutics. The role involves cross-functional collaboration, designing and interpreting in silico, in vitro, and in vivo analyses to support discovery with the desired DMPK profile, assessing DDI risk using mechanistic and PBPK models, authoring regulatory documents, and identifying program risks and mitigation strategies to enable efficient progression.
Responsibilities
Collaborate within cross-functional teams to support discovery and clinical development of therapeutics across modalities.
Guide design and interpretation of in silico, in vitro, and in vivo analyses to optimize DMPK profiles.
Assess DDI risk using static mechanistic and/or PBPK models and advise on DDI strategies for clinical development teams.
Author source reports and documents in support of regulatory filings (e.g., IB, IND) and responses to regulatory inquiries.
Independently evaluate program risks and implement strategies to address liabilities for efficient program progression.
Collaborate effectively in a fast-paced environment, driving scientific development and innovation; support both small molecule and biologics programs is desired.
Qualifications
Education minimum:
PhD or Master’s degree in Pharmaceutical Sciences, Pharmacology, Pharmacokinetics, Pharmacodynamics, Chemistry, Biomedical Engineering, Biochemistry, Toxicology, Biology, or relevant STEM field.
Required Experience and Skills:
Master’s degree with 10+ years or PhD with 7+ years of industry/applied drug discovery/development experience in therapeutics across modalities (small molecules, antibodies, drug conjugates).
Experience integrating preclinical DMPK and pharmacology to enable translational modeling and simulation for dose selection, PK/PD study design, and safety assessment.
Experience communicating analyses and recommendations to interdisciplinary teams and management.
Experience authoring documents for IB, IND, WMA filings and regulatory inquiries.
Demonstrated track record collaborating on multi-disciplinary discovery and development teams.
Strong leadership, interpersonal, communication, problem-solving, and collaboration skills with ability to meet deadlines.
Preferred Experience and Skills:
Strong publication track record.
Experience evaluating third-party assets for the DMPK function.
Experience building models and performing analyses using Phoenix and PBPK tools (e.g., SimCYP).
Experience mentoring or supervising junior staff.
Additional Information
Acknowledges Equal Employment Opportunity; includes commitments to non-discrimination and affirmative action as per applicable laws.
US and Puerto Rico residents only; hybrid work model applies to eligible roles. Remote work is available for this position where applicable.
Travel: 10%; Visa Sponsorship: Yes; Relocation: Domestic.
Compensation and Benefits
The salary range for this role is $169,700.00 - $267,200.00. Eligible for annual bonus and long-term incentive, where applicable. Comprehensive benefits include medical, dental, vision, retirement plans (401(k)), paid holidays, vacation, and sick days. More information is available at the employer’s compensation and benefits page. The application may be made through the company careers site or internal portals.
Job Posting End Date: 10/23/2025
Requisition ID: R369246
Note : This description does not include all duties of the position and may be revised at employer's discretion.
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The remote position is for applicants not within commutable distance to primary sites noted in the posting. The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) function of our Research & Development Division in West Point, Pennsylvania, is seeking a dynamic and collaborative scientist for the Drug Metabolism and Pharmacokinetics (DMPK) group. The Principal Scientist will contribute to multi-disciplinary drug development and discovery efforts, providing an integrated understanding of DMPK properties, pharmacokinetics/pharmacodynamics (PK/PD), and drug interaction (DDI) risk of novel therapeutics. The role involves cross-functional collaboration, designing and interpreting in silico, in vitro, and in vivo analyses to support discovery with the desired DMPK profile, assessing DDI risk using mechanistic and PBPK models, authoring regulatory documents, and identifying program risks and mitigation strategies to enable efficient progression.
Responsibilities
Collaborate within cross-functional teams to support discovery and clinical development of therapeutics across modalities.
Guide design and interpretation of in silico, in vitro, and in vivo analyses to optimize DMPK profiles.
Assess DDI risk using static mechanistic and/or PBPK models and advise on DDI strategies for clinical development teams.
Author source reports and documents in support of regulatory filings (e.g., IB, IND) and responses to regulatory inquiries.
Independently evaluate program risks and implement strategies to address liabilities for efficient program progression.
Collaborate effectively in a fast-paced environment, driving scientific development and innovation; support both small molecule and biologics programs is desired.
Qualifications
Education minimum:
PhD or Master’s degree in Pharmaceutical Sciences, Pharmacology, Pharmacokinetics, Pharmacodynamics, Chemistry, Biomedical Engineering, Biochemistry, Toxicology, Biology, or relevant STEM field.
Required Experience and Skills:
Master’s degree with 10+ years or PhD with 7+ years of industry/applied drug discovery/development experience in therapeutics across modalities (small molecules, antibodies, drug conjugates).
Experience integrating preclinical DMPK and pharmacology to enable translational modeling and simulation for dose selection, PK/PD study design, and safety assessment.
Experience communicating analyses and recommendations to interdisciplinary teams and management.
Experience authoring documents for IB, IND, WMA filings and regulatory inquiries.
Demonstrated track record collaborating on multi-disciplinary discovery and development teams.
Strong leadership, interpersonal, communication, problem-solving, and collaboration skills with ability to meet deadlines.
Preferred Experience and Skills:
Strong publication track record.
Experience evaluating third-party assets for the DMPK function.
Experience building models and performing analyses using Phoenix and PBPK tools (e.g., SimCYP).
Experience mentoring or supervising junior staff.
Additional Information
Acknowledges Equal Employment Opportunity; includes commitments to non-discrimination and affirmative action as per applicable laws.
US and Puerto Rico residents only; hybrid work model applies to eligible roles. Remote work is available for this position where applicable.
Travel: 10%; Visa Sponsorship: Yes; Relocation: Domestic.
Compensation and Benefits
The salary range for this role is $169,700.00 - $267,200.00. Eligible for annual bonus and long-term incentive, where applicable. Comprehensive benefits include medical, dental, vision, retirement plans (401(k)), paid holidays, vacation, and sick days. More information is available at the employer’s compensation and benefits page. The application may be made through the company careers site or internal portals.
Job Posting End Date: 10/23/2025
Requisition ID: R369246
Note : This description does not include all duties of the position and may be revised at employer's discretion.
#J-18808-Ljbffr