BioSpace
Overview
Scientist 1 Bioconjugation Chemistry at BioSpace. From research and discovery to post-market clinical development, our WWRD engine involves bench and clinical research and the groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases.
Responsibilities
Synthesis, optimization, and high-quality delivery of various polymer, protein/peptide, and lipidated bioconjugates in support of discovery and development of novel therapeutics, with an emphasis on oligonucleotides
Development and implementation of new linker chemistries/spacers and bioconjugation methods for targeted drug delivery
Leveraging appropriate purification and analytical characterization approaches for QC and validation
Collaboration with internal and external partners for material transfer to support in vitro and in vivo POC experiments; assemble data packages and maintain quality control documentation through Benchling for final product delivery
Effectively partner with cross-functional teams, sharing insights, troubleshooting issues, and driving science forward from the bench
Serve independently as bioconjugation technical lead and subject matter expert for internal and external project communications
Perform data analysis, interpret, and present results during internal and external meetings; attend and participate in scientific proceedings
Prepare and optimize chemistry SOPs
Participate and present data and share responsibility for project milestones
Qualifications
Education: Ph.D. in Chemical Engineering, Chemical Biology, Chemistry, or related fields is required; Scientist 1 will have 0-2 years of industry/post-doc experience relating to drug development
Strong foundation in macromolecular chemistry, bioconjugation, analytical chemistry and/or chemical biology is strongly desired
A record of accomplishments/publications in relevant scientific discipline and some hands-on experience in oligonucleotide delivery is preferred but not required
Extensive experience with different bioconjugation strategies and optimizations for polymers, proteins/peptides, lipids, oligonucleotides and other biomolecules
In-depth experience in bioconjugate purification techniques including various liquid chromatography methods (e.g. RP, IEX, SEC, HIC, affinity, FPLC) and membrane filtrations (e.g. TFF)
Prior experience in biochemistry techniques and analytical methods such as SEC-MALS, LCMS, SPR/BLI, ELISA, SDS-PAGE, enzyme activity assays, etc.
Willingness to learn new bioconjugation chemistries or delivery modalities and work across diverse therapeutic areas to develop protein therapeutics
Strong analytical mindset and chemistry problem-solving with creative thinking
Organization, attention to detail, self-motivation, and strong teamwork in a fast-paced setting
Equal Opportunity Employer Equal Opportunity Employer/Veterans/Disabled. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
Location and Compensation San Rafael, CA
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Responsibilities
Synthesis, optimization, and high-quality delivery of various polymer, protein/peptide, and lipidated bioconjugates in support of discovery and development of novel therapeutics, with an emphasis on oligonucleotides
Development and implementation of new linker chemistries/spacers and bioconjugation methods for targeted drug delivery
Leveraging appropriate purification and analytical characterization approaches for QC and validation
Collaboration with internal and external partners for material transfer to support in vitro and in vivo POC experiments; assemble data packages and maintain quality control documentation through Benchling for final product delivery
Effectively partner with cross-functional teams, sharing insights, troubleshooting issues, and driving science forward from the bench
Serve independently as bioconjugation technical lead and subject matter expert for internal and external project communications
Perform data analysis, interpret, and present results during internal and external meetings; attend and participate in scientific proceedings
Prepare and optimize chemistry SOPs
Participate and present data and share responsibility for project milestones
Qualifications
Education: Ph.D. in Chemical Engineering, Chemical Biology, Chemistry, or related fields is required; Scientist 1 will have 0-2 years of industry/post-doc experience relating to drug development
Strong foundation in macromolecular chemistry, bioconjugation, analytical chemistry and/or chemical biology is strongly desired
A record of accomplishments/publications in relevant scientific discipline and some hands-on experience in oligonucleotide delivery is preferred but not required
Extensive experience with different bioconjugation strategies and optimizations for polymers, proteins/peptides, lipids, oligonucleotides and other biomolecules
In-depth experience in bioconjugate purification techniques including various liquid chromatography methods (e.g. RP, IEX, SEC, HIC, affinity, FPLC) and membrane filtrations (e.g. TFF)
Prior experience in biochemistry techniques and analytical methods such as SEC-MALS, LCMS, SPR/BLI, ELISA, SDS-PAGE, enzyme activity assays, etc.
Willingness to learn new bioconjugation chemistries or delivery modalities and work across diverse therapeutic areas to develop protein therapeutics
Strong analytical mindset and chemistry problem-solving with creative thinking
Organization, attention to detail, self-motivation, and strong teamwork in a fast-paced setting
Equal Opportunity Employer Equal Opportunity Employer/Veterans/Disabled. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
Location and Compensation San Rafael, CA
#J-18808-Ljbffr