Bristol Myers Squibb
Scientist-Sr Scientist Discovery, Invitro Electrophysiology (Cardiovascular and
Bristol Myers Squibb, Princeton, New Jersey, us, 08543
Overview
Scientist-Sr Scientist Discovery, Invitro Electrophysiology (Cardiovascular and Neurology) We are seeking an experienced and motivated Research Scientist with at least 5 years of laboratory research experience in the pharmaceutical, biotechnology, or academic sectors. The successful candidate will play a key role in our Lawrenceville, NJ Discovery Toxicology team at Bristol Myers Squibb, contributing to early drug discovery through in vitro or ex vivo investigative toxicology studies focused on cardiovascular and nervous system safety assessment, mechanistic investigations, and early biomarker identification. High consideration will be given to candidates with Invitro Electrophysiology and Functional Neuron experience. This position will work within a dynamic, multidisciplinary, matrixed team environment, leveraging advanced cellular models including stem-cell derived cardiomyocytes and neurons, organoids, and microphysiological systems. Hands-on expertise with functional in vitro assays such as electrophysiology (patch-clamp, multielectrode array), dynamic calcium or fluorescence imaging, and exposure to new approach methodologies is required. The ideal candidate demonstrates a collaborative mindset, rigorous scientific approach, and outstanding communication and technical skills.
Key Responsibilities
Design, execute, and analyze in vitro studies evaluating cardiovascular or nervous system toxicity for early drug discovery targets and compounds. Develop, optimize, and apply functional assays—electrophysiological, contractility, impedance, imaging, and metabolic assays—using advanced cellular and tissue models for mechanistic safety investigation and biomarker discovery. Characterize on-target or off-target liabilities and pharmacodynamic endpoints in in vitro cellular or ex vivo tissue model systems. Perform multifaceted data analysis using specialized software, including analysis of large data sets and/or statistical programming. Author internal scientific reports, prepare manuscripts for publication, and present at internal/external meetings and conferences. Ensure excellent documentation and data recording in compliance with BMS standards and policies. Foster scientific excellence, open communication, and creativity to maximize team productivity.
Required Qualifications
PhD + 3 years, MA/MS + 5 years, BA/BS + 7 years of research experience (academic, biotech, pharma) in physiology, pharmacology, toxicology, or a closely related field. Proven expertise performing and interpreting functional cellular/tissue assays: patch-clamp (manual or automated) electrophysiology, multielectrode array electrophysiology, contractility, impedance, fluorescence imaging. Practical experience with organoids, microphysiological systems or other new approach methodologies. Practical experience with cell culture, including maintenance of cell lines, primary cell isolation and culture, and stem-cell derived models (cardiomyocytes, neurons). Skilled in data analysis, statistics, presentation, and scientific writing. Technically adept, logical, and proactive problem-solver. Effective communicator, capable of collaborating across teams and organizational levels.
Preferred Qualifications
Experience in In-Vitro Electrophysiology. Experience in Cardiovascular or Neurology. Experience with advanced imaging systems (confocal microscopy, image analysis software). Proficiency in molecular biology techniques: siRNA, PCR. Familiarity with in silico/computational toxicology approaches. Experience with manual and/or automated patch clamp (e.g. Patchliner, Port-a-Patch). Experience with cell isolation or tissue harvesting for use in functional in vitro/ex vivo assays (electrically excitable cells, smooth muscle, perfused organs).
Compensation & Benefits
The compensation overview and benefits vary by location. For this role in Princeton, NJ: $117,970 - $142,954. The starting compensation range for a full-time employee is based on skills, experience, and location. Additional incentive cash and stock opportunities may be available. Benefits may include medical, dental, vision, wellbeing programs, 401(k), disability and life insurance, paid time off, and other programs. Specific benefits depend on the applicable plans and location.
On-site Protocol & Accessibility
BMS has an occupancy structure that determines where an employee is required to conduct their work. Roles can be site-essential, site-by-design, field-based, or remote-by-design. Site-essential roles require 100% onsite work; site-by-design roles may offer a hybrid model with at least 50% onsite. BMS provides reasonable workplace accommodations and invites inquiries at adastaffingsupport@bms.com. Equal employment opportunity statements and accessibility information are available at careers.bms.com/eeo-accessibility.
Equal Opportunity
BMS cares about the well-being of its employees and communities and provides accommodations as required. Applicants with arrest and conviction records will be considered in accordance with applicable laws. For California residents, additional information is available at https://careers.bms.com/california-residents/.
Note: This posting excludes unrelated job listings and company-wide information not essential to the role.
#J-18808-Ljbffr
Scientist-Sr Scientist Discovery, Invitro Electrophysiology (Cardiovascular and Neurology) We are seeking an experienced and motivated Research Scientist with at least 5 years of laboratory research experience in the pharmaceutical, biotechnology, or academic sectors. The successful candidate will play a key role in our Lawrenceville, NJ Discovery Toxicology team at Bristol Myers Squibb, contributing to early drug discovery through in vitro or ex vivo investigative toxicology studies focused on cardiovascular and nervous system safety assessment, mechanistic investigations, and early biomarker identification. High consideration will be given to candidates with Invitro Electrophysiology and Functional Neuron experience. This position will work within a dynamic, multidisciplinary, matrixed team environment, leveraging advanced cellular models including stem-cell derived cardiomyocytes and neurons, organoids, and microphysiological systems. Hands-on expertise with functional in vitro assays such as electrophysiology (patch-clamp, multielectrode array), dynamic calcium or fluorescence imaging, and exposure to new approach methodologies is required. The ideal candidate demonstrates a collaborative mindset, rigorous scientific approach, and outstanding communication and technical skills.
Key Responsibilities
Design, execute, and analyze in vitro studies evaluating cardiovascular or nervous system toxicity for early drug discovery targets and compounds. Develop, optimize, and apply functional assays—electrophysiological, contractility, impedance, imaging, and metabolic assays—using advanced cellular and tissue models for mechanistic safety investigation and biomarker discovery. Characterize on-target or off-target liabilities and pharmacodynamic endpoints in in vitro cellular or ex vivo tissue model systems. Perform multifaceted data analysis using specialized software, including analysis of large data sets and/or statistical programming. Author internal scientific reports, prepare manuscripts for publication, and present at internal/external meetings and conferences. Ensure excellent documentation and data recording in compliance with BMS standards and policies. Foster scientific excellence, open communication, and creativity to maximize team productivity.
Required Qualifications
PhD + 3 years, MA/MS + 5 years, BA/BS + 7 years of research experience (academic, biotech, pharma) in physiology, pharmacology, toxicology, or a closely related field. Proven expertise performing and interpreting functional cellular/tissue assays: patch-clamp (manual or automated) electrophysiology, multielectrode array electrophysiology, contractility, impedance, fluorescence imaging. Practical experience with organoids, microphysiological systems or other new approach methodologies. Practical experience with cell culture, including maintenance of cell lines, primary cell isolation and culture, and stem-cell derived models (cardiomyocytes, neurons). Skilled in data analysis, statistics, presentation, and scientific writing. Technically adept, logical, and proactive problem-solver. Effective communicator, capable of collaborating across teams and organizational levels.
Preferred Qualifications
Experience in In-Vitro Electrophysiology. Experience in Cardiovascular or Neurology. Experience with advanced imaging systems (confocal microscopy, image analysis software). Proficiency in molecular biology techniques: siRNA, PCR. Familiarity with in silico/computational toxicology approaches. Experience with manual and/or automated patch clamp (e.g. Patchliner, Port-a-Patch). Experience with cell isolation or tissue harvesting for use in functional in vitro/ex vivo assays (electrically excitable cells, smooth muscle, perfused organs).
Compensation & Benefits
The compensation overview and benefits vary by location. For this role in Princeton, NJ: $117,970 - $142,954. The starting compensation range for a full-time employee is based on skills, experience, and location. Additional incentive cash and stock opportunities may be available. Benefits may include medical, dental, vision, wellbeing programs, 401(k), disability and life insurance, paid time off, and other programs. Specific benefits depend on the applicable plans and location.
On-site Protocol & Accessibility
BMS has an occupancy structure that determines where an employee is required to conduct their work. Roles can be site-essential, site-by-design, field-based, or remote-by-design. Site-essential roles require 100% onsite work; site-by-design roles may offer a hybrid model with at least 50% onsite. BMS provides reasonable workplace accommodations and invites inquiries at adastaffingsupport@bms.com. Equal employment opportunity statements and accessibility information are available at careers.bms.com/eeo-accessibility.
Equal Opportunity
BMS cares about the well-being of its employees and communities and provides accommodations as required. Applicants with arrest and conviction records will be considered in accordance with applicable laws. For California residents, additional information is available at https://careers.bms.com/california-residents/.
Note: This posting excludes unrelated job listings and company-wide information not essential to the role.
#J-18808-Ljbffr