Septerna
Senior Scientist/Staff Scientist, Protein Science (industry experience required)
Septerna, San Francisco, California, United States, 94199
Senior Scientist/Staff Scientist, Protein Science (industry experience required)
Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life‑changing medicines for patients with the vision to become the industry‑leading G protein–coupled receptor (GPCR) focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context, enabling novel access to modern structural and screening technologies for the entire class of GPCRs.
We are expanding a multidisciplinary team of scientists focused on creating revolutionary medicines. As a Senior/Staff Scientist, you will contribute to Seperna’s mission by utilizing innovative drug discovery technologies for GPCR targets.
Responsibilities
Perform hands‑on work to enable Septerna’s Native Complex™ platform.
Design, express, purify and characterize soluble and membrane proteins from mammalian, bacterial, and insect cells.
Develop and deploy parallel mid‑scale screening platforms to optimize protein quality and yield.
Collaborate with the protein science team to automate and streamline current protein production workflows.
Lead the design, execution, and interpretation of biochemical workflows.
Document and present data in group and project team meetings.
Support discovery, biophysics, and structural biology efforts for internal drug discovery programs.
Qualifications
PhD with a minimum of 5+ years, or BS/MS with 10+ years, of relevant experience in a biotechnology or pharmaceutical setting.
Proficiency in protein engineering, cell culture, and protein expression in bacterial, insect, and mammalian systems.
Expertise in design of protein expression constructs focused on parallel exploration of promoters, tags, and other elements.
Hands‑on experience with small‑scale multi‑parallel expression and purification.
Strong experience in protein purification using FPLC‑based column chromatography including affinity, ion exchange, and size exclusion.
Experience with membrane protein purification and characterization, particularly GPCRs, using detergents, nanodiscs, amphipols, or related technologies.
Knowledge of protein characterization techniques such as MALS, DSF, and analytical size exclusion.
Familiarity with automation and data analysis/reporting software.
Ability to work collaboratively across the organization while independently planning and interpreting experiments.
Clear and effective verbal and written communication skills.
The anticipated salary range for candidates who will work in South San Francisco, CA is $135,000 – $155,000. Individual pay may vary based on additional factors.
We are an Equal Opportunity Employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Septerna participates in the E‑Verify program.
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We are expanding a multidisciplinary team of scientists focused on creating revolutionary medicines. As a Senior/Staff Scientist, you will contribute to Seperna’s mission by utilizing innovative drug discovery technologies for GPCR targets.
Responsibilities
Perform hands‑on work to enable Septerna’s Native Complex™ platform.
Design, express, purify and characterize soluble and membrane proteins from mammalian, bacterial, and insect cells.
Develop and deploy parallel mid‑scale screening platforms to optimize protein quality and yield.
Collaborate with the protein science team to automate and streamline current protein production workflows.
Lead the design, execution, and interpretation of biochemical workflows.
Document and present data in group and project team meetings.
Support discovery, biophysics, and structural biology efforts for internal drug discovery programs.
Qualifications
PhD with a minimum of 5+ years, or BS/MS with 10+ years, of relevant experience in a biotechnology or pharmaceutical setting.
Proficiency in protein engineering, cell culture, and protein expression in bacterial, insect, and mammalian systems.
Expertise in design of protein expression constructs focused on parallel exploration of promoters, tags, and other elements.
Hands‑on experience with small‑scale multi‑parallel expression and purification.
Strong experience in protein purification using FPLC‑based column chromatography including affinity, ion exchange, and size exclusion.
Experience with membrane protein purification and characterization, particularly GPCRs, using detergents, nanodiscs, amphipols, or related technologies.
Knowledge of protein characterization techniques such as MALS, DSF, and analytical size exclusion.
Familiarity with automation and data analysis/reporting software.
Ability to work collaboratively across the organization while independently planning and interpreting experiments.
Clear and effective verbal and written communication skills.
The anticipated salary range for candidates who will work in South San Francisco, CA is $135,000 – $155,000. Individual pay may vary based on additional factors.
We are an Equal Opportunity Employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Septerna participates in the E‑Verify program.
#J-18808-Ljbffr