Brigham and Women's Hospital
Postdoc Research Fellow NEUROLOGY
Brigham and Women's Hospital, Boston, Massachusetts, us, 02298
Job Summary
A postdoc position is open in the laboratory of Silke Nuber in the Ann Romney Center for Neurologic Diseases in the Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, to study alpha‑synuclein biology in mice and cell culture models of Parkinson's disease (PD). The research focuses on determining whether gender or lipid‑dependent changes that affect the alpha‑synuclein tetramer:monomer ratio early in Parkinson’s pathology confer neuroprotection to specific neurons and brain regions.
The PI’s previous work demonstrated that upstream abrogation of normal alpha‑synuclein tetramers, the key protein in Lewy body pathology, induces a progressive, L‑DOPA‑responsive motor syndrome and cortical and dopaminergic fiber loss in familial PD mutant mice. The new project uses these unique mouse models to investigate early‑onset synucleinopathy and will generate new models to analyze tetramer abrogation by other familial PD mutations. Experimental approaches include behavioral testing as well as molecular, biochemical and neuropathological analyses.
Qualifications
A Ph.D. in neuroscience, biochemistry or a related biological field.
Excellent track record of publications, including in neurodegenerative disease.
Extensive experience with mouse studies, including behavior, listed in detail in the CV.
Experience in molecular biology, pathology and biochemistry, listed in detail in the CV.
Cell culture (primary neurons and/or induced human neurons) experience preferred, listed in detail in the CV.
Self‑motivated and driven individual able to work both independently and in a team environment.
Excellent oral and written communication skills in English.
Minimum three‑year commitment.
Responsibilities Conduct in‑vivo and in‑vitro experiments to investigate alpha‑synuclein biology, perform behavioral testing, and analyze molecular and neuropathological data. Collaborate with colleagues within and outside the laboratory, contribute to publications, and present findings at conferences.
Compensation NIH postdoctoral stipend levels will be followed.
Contact Dr. Silke Nuber (snuber@bwh.harvard.edu)
Karen Tobin (ktobin11@bwh.harvard.edu)
EEO Statement The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. All individuals with a disability will be provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. For accommodation requests, contact Human Resources at (857)-282-7642.
#J-18808-Ljbffr
The PI’s previous work demonstrated that upstream abrogation of normal alpha‑synuclein tetramers, the key protein in Lewy body pathology, induces a progressive, L‑DOPA‑responsive motor syndrome and cortical and dopaminergic fiber loss in familial PD mutant mice. The new project uses these unique mouse models to investigate early‑onset synucleinopathy and will generate new models to analyze tetramer abrogation by other familial PD mutations. Experimental approaches include behavioral testing as well as molecular, biochemical and neuropathological analyses.
Qualifications
A Ph.D. in neuroscience, biochemistry or a related biological field.
Excellent track record of publications, including in neurodegenerative disease.
Extensive experience with mouse studies, including behavior, listed in detail in the CV.
Experience in molecular biology, pathology and biochemistry, listed in detail in the CV.
Cell culture (primary neurons and/or induced human neurons) experience preferred, listed in detail in the CV.
Self‑motivated and driven individual able to work both independently and in a team environment.
Excellent oral and written communication skills in English.
Minimum three‑year commitment.
Responsibilities Conduct in‑vivo and in‑vitro experiments to investigate alpha‑synuclein biology, perform behavioral testing, and analyze molecular and neuropathological data. Collaborate with colleagues within and outside the laboratory, contribute to publications, and present findings at conferences.
Compensation NIH postdoctoral stipend levels will be followed.
Contact Dr. Silke Nuber (snuber@bwh.harvard.edu)
Karen Tobin (ktobin11@bwh.harvard.edu)
EEO Statement The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. All individuals with a disability will be provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. For accommodation requests, contact Human Resources at (857)-282-7642.
#J-18808-Ljbffr