Outpace Bio
About Outpace Bio
Outpace Bio is pioneering the future of cell therapy for solid tumors by harnessing unrivaled AI‑powered protein design. Our mission is to program immune cells for enhanced function inside patients, overcoming key barriers such as poor tumor access, weak survival, antigen escape, and dose‑related toxicity. By creating modular, plug‑and‑play technology assets, we develop cell therapies with unprecedented efficacy, transforming how engineered T cells interact with cancer and the immune system to deliver life‑changing outcomes. Our multidisciplinary team—scientists, engineers, coders, and cell‑therapy developers—works at the cutting edge of computational protein design, synthetic biology, and immunology.
Our Commitment to Diversity At Outpace Bio, we believe that the highest performing teams include people from a wide variety of backgrounds and experiences. We are committed to cultivating an open, diverse, and inclusive culture for all employees.
Our Momentum In August 2024, Outpace Bio secured an oversubscribed $144 million Series B financing, led by RA Capital Management and supported by a premier syndicate of life science investors. This funding accelerates our pipeline of programmed T‑cell therapies, including our lead candidate OPB‑101, a mesothelin‑specific CAR T‑cell enhanced by our proprietary OUTSMART™, OUTLAST™, OUTSPACER™, and OUTSAFE™ technologies. OPB‑101 is advancing toward IND clearance and first dosing in 2025 for patients with advanced platinum‑resistant ovarian cancers.
Role Overview We are seeking a Senior Research Associate or Scientist I to join the viral vector production team. In this role you will produce, purify, and characterize lentivirus for our cell and gene therapy applications, work collaboratively with Immunology, In Vivo, and Cloning teams, and contribute to the development of novel viral assays and scale‑up process improvement.
Responsibilities
Produce and characterize lentivirus supporting multiple Outpace research and pipeline programs
Design and execute optimization experiments to improve viral titers, purity, and production efficiency
Support scale‑up of lentiviral production for process development and preclinical in‑vivo studies
Perform and optimize functional titer and genome quantitation assays (flow cytometry, ddPCR/dPCR)
Contribute to the development of improved upstream and downstream vector production and purification methodologies
Contribute to experiment design, data analysis, and presentation of results in internal meetings
Contribute to authoring or reviewing protocols, reports, or regulatory filings
Qualifications (Required)
Ability to work independently on experimental design, execution, and troubleshooting
Proficiency in mammalian cell culture and aseptic technique
Hands‑on experience with small‑scale lentivirus production (adherent or suspension systems)
Working knowledge of chromatography and filtration principles, downstream bioprocessing, and process scale‑up
Experience operating chromatography systems (AKTA or equivalent)
Experience with filtration operations including UF/DF and depth filtration
Highly organized with strong attention to detail and data quality
Ability to learn new protocols quickly and apply critical thinking to problem‑solving
Effective scientific communication skills with ability to discuss results and collaborate with team members
Experience measuring viral titer by flow cytometry and ddPCR/digital PCR
Hands‑on experience with transfection and transduction protocols
Experience safely handling lentivirus under BSL‑2 conditions
3+ years of research experience with mammalian cell culture systems
Qualifications (Preferred)
Master's or PhD in Virology, Molecular Biology, Immunology, Cell Biology, Gene Therapy, or related field; alternatively, Bachelor's degree with substantial position‑relevant research experience in academic or industry setting
Lentivirus process development in suspension culture formats (96‑well, 24‑well, shake flask, and 1‑5 L bioreactor scales)
Downstream viral vector processing including tangential flow filtration (TFF) and chromatography‑based purification
Familiarity with molecular biology techniques including nucleic acid isolation, quantification, and PCR‑based methods
Experience with mammalian cell culture in bioreactor systems
Experience in a startup or fast‑paced biotech setting
Experience with Electronic Lab Notebook (ELN) systems (Benchling)
Ability to manage multiple projects, prioritize workflow, meet deadlines, and collaborate effectively in cross‑functional teams
Familiarity with other viral vector platforms (gamma retrovirus, AAV)
Compensation $90,000 – $130,000 per year, commensurate with experience. Salary ranges are based on the level (Senior Research Associate: $90,000–$105,000; Scientist I: $111,000–$130,000).
Benefits Full‑time employees and eligible dependents are eligible for medical, dental, vision, life insurance, disability, flexible spending account, and 401(k) plans; stock option grants and performance bonuses are offered; generous paid parental leave, flexible PTO, paid sick leave, and fifteen paid holidays plus a winter shutdown.
EEO Statement Outpace Bio is committed to a diverse workforce. Employment decisions will be made without discrimination based on protected characteristics, in accordance with applicable laws.
Authorization to Work Applicants must be authorized to work in the United States. Candidates who are legally authorized and do not require sponsorship are encouraged to apply.
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Our Commitment to Diversity At Outpace Bio, we believe that the highest performing teams include people from a wide variety of backgrounds and experiences. We are committed to cultivating an open, diverse, and inclusive culture for all employees.
Our Momentum In August 2024, Outpace Bio secured an oversubscribed $144 million Series B financing, led by RA Capital Management and supported by a premier syndicate of life science investors. This funding accelerates our pipeline of programmed T‑cell therapies, including our lead candidate OPB‑101, a mesothelin‑specific CAR T‑cell enhanced by our proprietary OUTSMART™, OUTLAST™, OUTSPACER™, and OUTSAFE™ technologies. OPB‑101 is advancing toward IND clearance and first dosing in 2025 for patients with advanced platinum‑resistant ovarian cancers.
Role Overview We are seeking a Senior Research Associate or Scientist I to join the viral vector production team. In this role you will produce, purify, and characterize lentivirus for our cell and gene therapy applications, work collaboratively with Immunology, In Vivo, and Cloning teams, and contribute to the development of novel viral assays and scale‑up process improvement.
Responsibilities
Produce and characterize lentivirus supporting multiple Outpace research and pipeline programs
Design and execute optimization experiments to improve viral titers, purity, and production efficiency
Support scale‑up of lentiviral production for process development and preclinical in‑vivo studies
Perform and optimize functional titer and genome quantitation assays (flow cytometry, ddPCR/dPCR)
Contribute to the development of improved upstream and downstream vector production and purification methodologies
Contribute to experiment design, data analysis, and presentation of results in internal meetings
Contribute to authoring or reviewing protocols, reports, or regulatory filings
Qualifications (Required)
Ability to work independently on experimental design, execution, and troubleshooting
Proficiency in mammalian cell culture and aseptic technique
Hands‑on experience with small‑scale lentivirus production (adherent or suspension systems)
Working knowledge of chromatography and filtration principles, downstream bioprocessing, and process scale‑up
Experience operating chromatography systems (AKTA or equivalent)
Experience with filtration operations including UF/DF and depth filtration
Highly organized with strong attention to detail and data quality
Ability to learn new protocols quickly and apply critical thinking to problem‑solving
Effective scientific communication skills with ability to discuss results and collaborate with team members
Experience measuring viral titer by flow cytometry and ddPCR/digital PCR
Hands‑on experience with transfection and transduction protocols
Experience safely handling lentivirus under BSL‑2 conditions
3+ years of research experience with mammalian cell culture systems
Qualifications (Preferred)
Master's or PhD in Virology, Molecular Biology, Immunology, Cell Biology, Gene Therapy, or related field; alternatively, Bachelor's degree with substantial position‑relevant research experience in academic or industry setting
Lentivirus process development in suspension culture formats (96‑well, 24‑well, shake flask, and 1‑5 L bioreactor scales)
Downstream viral vector processing including tangential flow filtration (TFF) and chromatography‑based purification
Familiarity with molecular biology techniques including nucleic acid isolation, quantification, and PCR‑based methods
Experience with mammalian cell culture in bioreactor systems
Experience in a startup or fast‑paced biotech setting
Experience with Electronic Lab Notebook (ELN) systems (Benchling)
Ability to manage multiple projects, prioritize workflow, meet deadlines, and collaborate effectively in cross‑functional teams
Familiarity with other viral vector platforms (gamma retrovirus, AAV)
Compensation $90,000 – $130,000 per year, commensurate with experience. Salary ranges are based on the level (Senior Research Associate: $90,000–$105,000; Scientist I: $111,000–$130,000).
Benefits Full‑time employees and eligible dependents are eligible for medical, dental, vision, life insurance, disability, flexible spending account, and 401(k) plans; stock option grants and performance bonuses are offered; generous paid parental leave, flexible PTO, paid sick leave, and fifteen paid holidays plus a winter shutdown.
EEO Statement Outpace Bio is committed to a diverse workforce. Employment decisions will be made without discrimination based on protected characteristics, in accordance with applicable laws.
Authorization to Work Applicants must be authorized to work in the United States. Candidates who are legally authorized and do not require sponsorship are encouraged to apply.
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