Mariana Oncology, Inc.
Overview
Reporting: Principal Scientist, Bioanalytical Sciences Position: Senior Research Associate I/II, Bioanalytical Sciences – Preclinical Development This laboratory-based position will conduct LC-MS-based bioanalysis to support pharmacokinetic (PK), in vitro ADME, and proteomics studies across preclinical programs, focusing on sample preparation, method execution, and data collection. The successful candidate will contribute to the development of novel therapeutics by generating high-quality quantitative and qualitative bioanalytical data. Illustrative Breadth of Responsibilities
Perform routine quantitative bioanalysis of small molecules in biological matrices (e.g., plasma, serum, cell lysate, tissue) for downstream LC-MS analysis Support method development and qualification, as well as routine sample analysis for pharmacokinetics, metabolite profiling, and stability assessments Assist with proteomics sample preparation workflows, including protein digestion, peptide cleanup, and LC-MS-based quantification Contribute to in vitro ADME method development and optimization as needed Operate and maintain LC-MS/MS instrumentation for quantitative bioanalysis; evaluate assay and instrument performance and troubleshoot issues Maintain a well-documented electronic laboratory notebook (ELN) with complete and accurate experimental details, sample records, and data entries Collaborate with bioanalytical scientists and cross-functional teams to ensure timely generation and delivery of high-quality data Follow standard operating procedures (SOPs), comply with safety regulations, and adhere to safe laboratory practices Requirements/Skills
Bachelor’s degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences or a related scientific discipline with 2–5+ years of R&D experience in the pharmaceutical, biotechnology, or CRO environment; Master’s degree with 1+ year of relevant R&D experience Solid experience with LC-MS/MS sample preparation/extraction techniques (e.g., protein precipitation, SPE, LLE) for small molecules from biological matrices (plasma, serum, tissue) Strong background in bioanalytical assay development, qualification, and validation Familiarity with PK and ADME workflows is preferred Understanding of chromatographic principles and mass spectrometry fundamentals is preferred but not required Experience with automated liquid handling for high-throughput sample preparation is a plus Experience with proteomics sample preparation workflows is a plus Commitment to data integrity through adherence to standardized procedures and relevant compliance requirements Willingness to learn and adhere to radiation safety regulations and guidelines Strong communication skills and the ability to work effectively with others and maintain good working relationships Mariana Oncology’s Principles
Building a Legacy Execution Excellence Courage of our Convictions
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Reporting: Principal Scientist, Bioanalytical Sciences Position: Senior Research Associate I/II, Bioanalytical Sciences – Preclinical Development This laboratory-based position will conduct LC-MS-based bioanalysis to support pharmacokinetic (PK), in vitro ADME, and proteomics studies across preclinical programs, focusing on sample preparation, method execution, and data collection. The successful candidate will contribute to the development of novel therapeutics by generating high-quality quantitative and qualitative bioanalytical data. Illustrative Breadth of Responsibilities
Perform routine quantitative bioanalysis of small molecules in biological matrices (e.g., plasma, serum, cell lysate, tissue) for downstream LC-MS analysis Support method development and qualification, as well as routine sample analysis for pharmacokinetics, metabolite profiling, and stability assessments Assist with proteomics sample preparation workflows, including protein digestion, peptide cleanup, and LC-MS-based quantification Contribute to in vitro ADME method development and optimization as needed Operate and maintain LC-MS/MS instrumentation for quantitative bioanalysis; evaluate assay and instrument performance and troubleshoot issues Maintain a well-documented electronic laboratory notebook (ELN) with complete and accurate experimental details, sample records, and data entries Collaborate with bioanalytical scientists and cross-functional teams to ensure timely generation and delivery of high-quality data Follow standard operating procedures (SOPs), comply with safety regulations, and adhere to safe laboratory practices Requirements/Skills
Bachelor’s degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences or a related scientific discipline with 2–5+ years of R&D experience in the pharmaceutical, biotechnology, or CRO environment; Master’s degree with 1+ year of relevant R&D experience Solid experience with LC-MS/MS sample preparation/extraction techniques (e.g., protein precipitation, SPE, LLE) for small molecules from biological matrices (plasma, serum, tissue) Strong background in bioanalytical assay development, qualification, and validation Familiarity with PK and ADME workflows is preferred Understanding of chromatographic principles and mass spectrometry fundamentals is preferred but not required Experience with automated liquid handling for high-throughput sample preparation is a plus Experience with proteomics sample preparation workflows is a plus Commitment to data integrity through adherence to standardized procedures and relevant compliance requirements Willingness to learn and adhere to radiation safety regulations and guidelines Strong communication skills and the ability to work effectively with others and maintain good working relationships Mariana Oncology’s Principles
Building a Legacy Execution Excellence Courage of our Convictions
#J-18808-Ljbffr