Yale University
Research Associate 1 MS
– Yale University
Working at Yale means contributing to a better tomorrow. Whether you are a current resident of our New Haven-based community‑eligible for opportunities through the New Haven Hiring Initiative or a newcomer, interested in exploring all that Yale has to offer, your talents and contributions are welcome. Discover your opportunities at Yale!
Salary Range
$61,500.00 - $91,875.00
The Yale DNA Diagnostic Lab is seeking a highly motivated and detail-oriented Research Associate for independent development of new genetic tests based on cutting‑edge technologies. Nanopore, PacBio, and newer‑generation instruments will be used for long‑read DNA sequencing, detection of structural genomic variants, RNA sequencing, and global methylation analysis. These technical capabilities will allow the lab to develop testing for trinucleotide‑expansion diseases, complicated cancer‑genome rearrangements, imprinting disorders, and complex chromosomal regions that are not amenable to chromosome microarrays, standard whole‑exome, or standard whole genome sequencing. This individual will work closely with DNA Diagnostic Laboratory Directors, bioinformatics specialists, and the Directors of the Yale Center for Genome Analysis to move this technology into the clinical realm. By testing positive and negative control clinical samples this research associate will determine test characteristics such as sensitivity, specificity, accuracy, and reproducibility. Ultimately, standard operating procedures compliant with federal and state regulations will be developed, and C&T technical staff will be trained to apply this new technology.
Required Skills and Abilities
Scientific and Technical Proficiency: Background in molecular biology, chemistry, genetics, or physical sciences with experience in techniques such as PCR, sequencing, microscopy, and cell culture.
Interpersonal and Communication Skills: Excellent oral and written communication skills to interact with internal and external stakeholders, including research staff, study sponsors, and collaborators.
Organizational Skills: Strong organizational skills with attention to detail, ability to manage multiple projects simultaneously, and prioritize tasks effectively in a fast‑paced environment.
Independent Research: Demonstrated ability to perform independent research, analyze and interpret experimental data, and contribute to scientific reports and publications.
Team Collaboration: Ability to work well as part of a team, provide instruction and guidance, and contribute to the overall objectives of the research projects.
Preferred Skills and Abilities
Thorough knowledge of theories and principles of human genetics and genomics.
Familiarity with genomic tools and databases such as Online Mendelian Inheritance in Man (OMIM), ClinVar database of disease‑related variants, GnomAD database of population frequencies of variants, in silico predictors of variant effect (SIFT, POLYPHEN, Splice AI and others), IGV for viewing genomic data, and others.
Ability to analyze whole‑exome DNA sequence and whole genome DNA sequence for variants related to human disease.
Knowledge of regulatory requirements for clinical laboratories including the Clinical Laboratory Improvement Act (CLIA) and the College of American Pathologists (CAP).
Knowledge of regulatory requirements for laboratory safety and research (HIPAA and ethical guidelines for human research).
Ability to use and maintain specialized laboratory equipment and software, with expertise in handling and analyzing large data sets.
Experience with clinical data analysis tools (e.g., EPIC and the embedded Beaker Laboratory Information System used by the DNA Diagnostics Laboratory).
Proficiency with MS Word, Excel, Adobe Photoshop, and PowerPoint.
Principal Responsibilities
Recommend the design and implementation of procedures and protocols under the direction of a higher‑level authority.
Investigate, analyze, and reach preliminary scientific conclusions related to research planning.
Ensure data results are compiled, analyzed, and presented properly.
Analyze, develop and interpret scientific results and maintain clear documentation of results.
Prepare scientific reports and papers for research proposals and published reports.
Perform independent research and laboratory techniques and participate in experimental research planning.
Interact with internal contacts including the PI, research assistants, graduate students, Radiation Safety and Biological Safety officers, and Animal Care personnel to discuss and evaluate research results and ensure the smooth and safe operation of the laboratory.
Interact with external contacts such as researchers at other institutions, staff at biotechnology and reagents companies to consult on research methods and keep abreast of product information and developments.
May perform other duties as assigned.
Required Education and Experience Master’s Degree in a scientific discipline and one year experience or an equivalent combination of education and experience.
Job Information
Job Posting Date: 10/23/2025
Job Category: Professional
Bargaining Unit: NON
Compensation Grade: Clinical & Research
Compensation Grade Profile: Research Associate 1 MS (22)
Time Type: Full time
Duration Type: Staff
Work Model: On‑site
Location: 333 Cedar Street, New Haven, Connecticut
Background Check Requirements All candidates for employment will be subject to pre‑employment background screening for this position, which may include motor vehicle, DOT certification, drug testing and credit checks based on the position description and job requirements. All offers are contingent upon the successful completion of the background check. For additional information on the background check requirements and process visit "Learn about background checks" under the Applicant Support Resources section of Careers on the It's Your Yale website.
Health Requirements Certain positions have associated health requirements based on specific job responsibilities. These may include vaccinations, tests, or examinations, as required by law, regulation, or university policy.
Posting Disclaimer Salary offers are determined by a candidate’s qualifications, experience, skills, and education in relation to the position requirements, along with the role’s grade profile and current internal and external market conditions.
The intent of this job description is to provide a representative summary of the essential functions that will be required of the position and should not be construed as a declaration of specific duties and responsibilities of the position. Employees will be assigned specific job‑related duties through their hiring department.
The University is committed to basing judgments concerning the admission, education, and employment of individuals upon their qualifications and abilities and seeks to attract to its faculty, staff, and student body qualified persons from a broad range of backgrounds and perspectives. In accordance with this policy and as delineated by federal and Connecticut law, Yale does not discriminate in admissions, educational programs, or employment against any individual on account of that individual’s sex, sexual orientation, gender identity or expression, race, color, national or ethnic origin, religion, age, disability, status as a special disabled veteran, veteran of the Vietnam era or other covered veteran.
Inquiries concerning Yale’s Policy Against Discrimination and Harassment may be referred to the Office of Institutional Equity and Accessibility (OIEA).
Note: Yale University is a tobacco‑free campus.
#J-18808-Ljbffr
– Yale University
Working at Yale means contributing to a better tomorrow. Whether you are a current resident of our New Haven-based community‑eligible for opportunities through the New Haven Hiring Initiative or a newcomer, interested in exploring all that Yale has to offer, your talents and contributions are welcome. Discover your opportunities at Yale!
Salary Range
$61,500.00 - $91,875.00
The Yale DNA Diagnostic Lab is seeking a highly motivated and detail-oriented Research Associate for independent development of new genetic tests based on cutting‑edge technologies. Nanopore, PacBio, and newer‑generation instruments will be used for long‑read DNA sequencing, detection of structural genomic variants, RNA sequencing, and global methylation analysis. These technical capabilities will allow the lab to develop testing for trinucleotide‑expansion diseases, complicated cancer‑genome rearrangements, imprinting disorders, and complex chromosomal regions that are not amenable to chromosome microarrays, standard whole‑exome, or standard whole genome sequencing. This individual will work closely with DNA Diagnostic Laboratory Directors, bioinformatics specialists, and the Directors of the Yale Center for Genome Analysis to move this technology into the clinical realm. By testing positive and negative control clinical samples this research associate will determine test characteristics such as sensitivity, specificity, accuracy, and reproducibility. Ultimately, standard operating procedures compliant with federal and state regulations will be developed, and C&T technical staff will be trained to apply this new technology.
Required Skills and Abilities
Scientific and Technical Proficiency: Background in molecular biology, chemistry, genetics, or physical sciences with experience in techniques such as PCR, sequencing, microscopy, and cell culture.
Interpersonal and Communication Skills: Excellent oral and written communication skills to interact with internal and external stakeholders, including research staff, study sponsors, and collaborators.
Organizational Skills: Strong organizational skills with attention to detail, ability to manage multiple projects simultaneously, and prioritize tasks effectively in a fast‑paced environment.
Independent Research: Demonstrated ability to perform independent research, analyze and interpret experimental data, and contribute to scientific reports and publications.
Team Collaboration: Ability to work well as part of a team, provide instruction and guidance, and contribute to the overall objectives of the research projects.
Preferred Skills and Abilities
Thorough knowledge of theories and principles of human genetics and genomics.
Familiarity with genomic tools and databases such as Online Mendelian Inheritance in Man (OMIM), ClinVar database of disease‑related variants, GnomAD database of population frequencies of variants, in silico predictors of variant effect (SIFT, POLYPHEN, Splice AI and others), IGV for viewing genomic data, and others.
Ability to analyze whole‑exome DNA sequence and whole genome DNA sequence for variants related to human disease.
Knowledge of regulatory requirements for clinical laboratories including the Clinical Laboratory Improvement Act (CLIA) and the College of American Pathologists (CAP).
Knowledge of regulatory requirements for laboratory safety and research (HIPAA and ethical guidelines for human research).
Ability to use and maintain specialized laboratory equipment and software, with expertise in handling and analyzing large data sets.
Experience with clinical data analysis tools (e.g., EPIC and the embedded Beaker Laboratory Information System used by the DNA Diagnostics Laboratory).
Proficiency with MS Word, Excel, Adobe Photoshop, and PowerPoint.
Principal Responsibilities
Recommend the design and implementation of procedures and protocols under the direction of a higher‑level authority.
Investigate, analyze, and reach preliminary scientific conclusions related to research planning.
Ensure data results are compiled, analyzed, and presented properly.
Analyze, develop and interpret scientific results and maintain clear documentation of results.
Prepare scientific reports and papers for research proposals and published reports.
Perform independent research and laboratory techniques and participate in experimental research planning.
Interact with internal contacts including the PI, research assistants, graduate students, Radiation Safety and Biological Safety officers, and Animal Care personnel to discuss and evaluate research results and ensure the smooth and safe operation of the laboratory.
Interact with external contacts such as researchers at other institutions, staff at biotechnology and reagents companies to consult on research methods and keep abreast of product information and developments.
May perform other duties as assigned.
Required Education and Experience Master’s Degree in a scientific discipline and one year experience or an equivalent combination of education and experience.
Job Information
Job Posting Date: 10/23/2025
Job Category: Professional
Bargaining Unit: NON
Compensation Grade: Clinical & Research
Compensation Grade Profile: Research Associate 1 MS (22)
Time Type: Full time
Duration Type: Staff
Work Model: On‑site
Location: 333 Cedar Street, New Haven, Connecticut
Background Check Requirements All candidates for employment will be subject to pre‑employment background screening for this position, which may include motor vehicle, DOT certification, drug testing and credit checks based on the position description and job requirements. All offers are contingent upon the successful completion of the background check. For additional information on the background check requirements and process visit "Learn about background checks" under the Applicant Support Resources section of Careers on the It's Your Yale website.
Health Requirements Certain positions have associated health requirements based on specific job responsibilities. These may include vaccinations, tests, or examinations, as required by law, regulation, or university policy.
Posting Disclaimer Salary offers are determined by a candidate’s qualifications, experience, skills, and education in relation to the position requirements, along with the role’s grade profile and current internal and external market conditions.
The intent of this job description is to provide a representative summary of the essential functions that will be required of the position and should not be construed as a declaration of specific duties and responsibilities of the position. Employees will be assigned specific job‑related duties through their hiring department.
The University is committed to basing judgments concerning the admission, education, and employment of individuals upon their qualifications and abilities and seeks to attract to its faculty, staff, and student body qualified persons from a broad range of backgrounds and perspectives. In accordance with this policy and as delineated by federal and Connecticut law, Yale does not discriminate in admissions, educational programs, or employment against any individual on account of that individual’s sex, sexual orientation, gender identity or expression, race, color, national or ethnic origin, religion, age, disability, status as a special disabled veteran, veteran of the Vietnam era or other covered veteran.
Inquiries concerning Yale’s Policy Against Discrimination and Harassment may be referred to the Office of Institutional Equity and Accessibility (OIEA).
Note: Yale University is a tobacco‑free campus.
#J-18808-Ljbffr