Systimmune
Scientist/ Research Associate – AI Protein Design
Systimmune, Redmond, Washington, United States, 98052
SystImmune is a leading and well-funded clinical‑stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi‑specific, multi‑specific antibodies, and antibody‑drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND‑enabling stages, representing cutting‑edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.
We are looking for a creative and motivated individual to execute and improve our Computational Protein Design pipeline using data‑driven approaches to augment our first‑in‑class multi‑specific biological programs. The ideal candidate will have experience applying computational methods to design novel peptides and proteins, with expertise in structural modeling, prediction, and optimization.
Responsibilities
Execute a computational design pipeline for predicting the properties of peptides, natural ligands, de novo proteins, and antibody‑based elements via data‑driven approach
Drive assay validation, tech transfer, and development initiatives to maintain industry standards; contribute within the computational protein design group to operate yeast display‑based protein discovery platforms
Design new macromolecular therapeutics using structural and sequence analysis, and employ these in silico predictions to iteratively guide the lead development process
Analyze, interpret, document, and present data to the scientific and leadership team
Collaborate with our Antibody Discovery, Protein Engineering, and Immuno‑oncology teams to contribute to the company’s vision
Qualifications
PhD (or equivalent) in bioengineering, biophysics, biochemistry, molecular biology, cell biology, or a related field
8+ years of experience using yeast libraries to generate protein binding or therapeutic antibodies required
Experience with relevant macromolecular modeling software (e.g., AlphaFold, RoseTTAFold, RFdiffusion, ProteinMPNN, Gromacs, MOE, Schrödinger)
Expertise in screening and ranking of antibodies (ELISA, multi‑parametric flow cytometry, BLI/OCTET)
Proven contribution to therapeutic antibody development and selection is desirable; design and validation of novel biologically relevant antibodies are highly desirable
Compensation and Benefits The expected base salary range for this position is $80,000 – $180,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s qualifications, experience, and skills. While most offers typically fall within the low to mid‑point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise align strongly with the requirements of the role.
SystImmune offers a comprehensive benefits package including 100% paid employee premiums for medical/dental/vision, STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.
SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.
#J-18808-Ljbffr
We are looking for a creative and motivated individual to execute and improve our Computational Protein Design pipeline using data‑driven approaches to augment our first‑in‑class multi‑specific biological programs. The ideal candidate will have experience applying computational methods to design novel peptides and proteins, with expertise in structural modeling, prediction, and optimization.
Responsibilities
Execute a computational design pipeline for predicting the properties of peptides, natural ligands, de novo proteins, and antibody‑based elements via data‑driven approach
Drive assay validation, tech transfer, and development initiatives to maintain industry standards; contribute within the computational protein design group to operate yeast display‑based protein discovery platforms
Design new macromolecular therapeutics using structural and sequence analysis, and employ these in silico predictions to iteratively guide the lead development process
Analyze, interpret, document, and present data to the scientific and leadership team
Collaborate with our Antibody Discovery, Protein Engineering, and Immuno‑oncology teams to contribute to the company’s vision
Qualifications
PhD (or equivalent) in bioengineering, biophysics, biochemistry, molecular biology, cell biology, or a related field
8+ years of experience using yeast libraries to generate protein binding or therapeutic antibodies required
Experience with relevant macromolecular modeling software (e.g., AlphaFold, RoseTTAFold, RFdiffusion, ProteinMPNN, Gromacs, MOE, Schrödinger)
Expertise in screening and ranking of antibodies (ELISA, multi‑parametric flow cytometry, BLI/OCTET)
Proven contribution to therapeutic antibody development and selection is desirable; design and validation of novel biologically relevant antibodies are highly desirable
Compensation and Benefits The expected base salary range for this position is $80,000 – $180,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s qualifications, experience, and skills. While most offers typically fall within the low to mid‑point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise align strongly with the requirements of the role.
SystImmune offers a comprehensive benefits package including 100% paid employee premiums for medical/dental/vision, STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.
SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.
#J-18808-Ljbffr