San Diego Biomedical Research Institute
Postdoctoral Fellow
San Diego Biomedical Research Institute, San Diego, California, United States, 92189
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Direct message the job poster from San Diego Biomedical Research Institute
About San Diego BioMed San Diego BioMed (SDB) is a nonprofit biomedical research institute located in San Diego, California. The mission of SDB is to conduct fundamental biomedical research to better understand human disease, and to use this information to contribute to the treatment and prevention of diabetes, cancer, neurological disease, HIV infection and complications of chronic disease.
Position Overview San Diego BioMed (SDB) is seeking a Postdoctoral Fellow to elucidate how Early Replication Control Elements (ERCEs) regulate changes in DNA replication timing. The ideal candidate is on a clear trajectory toward an independent research program exploring: (i) the role of replication timing in cell‑fate transitions; (ii) the impact of ERCE sequence variation on phenotypic traits; and/or (iii) the potential of ERCEs as tools for cell therapy.
The position is available immediately in San Diego, California in the laboratory of Dr. David M. Gilbert, Professor. There is flexibility to accommodate thesis defenses, publication timelines, and other standard career transitions.
Research Focus
Primary system: a hybrid CAST×129 pluripotent stem cell culture model optimized for ERCE discovery and functional testing.
Extensions: flexibility to pursue human ESCs and engineered cellular models. Initial thrust: a high‑throughput ERCE activity screen to identify sequences capable of manipulating replication timing, with the broader aim of defining biological significance and translational potential.
Variant mining: discovery of ERCE variants associated with phenotypic and disease traits, in conjunction with other research collaborators.
Mentoring & Career Development
Close one‑on‑one mentorship in experimental design, manuscript and grant preparation, and strategic career planning.
Active integration into collaborative networks and project leadership opportunities.
Minimum Requirements
Ph.D. (or M.D./Ph.D.) in molecular biology, genomics, epigenetics, computational biology, or a related field.
Demonstrated expertise in one or more of: genome engineering, functional genomics, epigenome/replication profiling, single‑cell methods, or regulatory sequence analysis. Strong record of productivity, scientific rigor, and a collaborative mindset. Ambition to build an independent program centered on replication timing and ERCE biology.
Salary Range $70,500 – $72,500
Benefits San Diego BioMed offers a competitive benefits package, including medical, dental, vision, life insurance, long‑term disability, paid time off, and a generous employer match to the retirement plan. The work environment at San Diego BioMed is one that fosters and promotes collaboration and inclusivity.
Applying for the Position
CV
Brief cover letter describing how your career goals align with this position
Names, affiliations, and contact information (email and phone) for at least three references (include in cover letter)
San Diego BioMed is committed to a policy of equal employment opportunity in regard to recruiting, hiring, training and promoting the most qualified individuals, without regard to race, color, creed, religion, sex, sexual orientation, gender, gender identity and expression, marital status, age, registered domestic partner status, national origin or ancestry, physical or mental disability, age, disability, protected veteran status, medical condition including genetic characteristics, or any other protected status as designed by federal, state, or local law.
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Direct message the job poster from San Diego Biomedical Research Institute
About San Diego BioMed San Diego BioMed (SDB) is a nonprofit biomedical research institute located in San Diego, California. The mission of SDB is to conduct fundamental biomedical research to better understand human disease, and to use this information to contribute to the treatment and prevention of diabetes, cancer, neurological disease, HIV infection and complications of chronic disease.
Position Overview San Diego BioMed (SDB) is seeking a Postdoctoral Fellow to elucidate how Early Replication Control Elements (ERCEs) regulate changes in DNA replication timing. The ideal candidate is on a clear trajectory toward an independent research program exploring: (i) the role of replication timing in cell‑fate transitions; (ii) the impact of ERCE sequence variation on phenotypic traits; and/or (iii) the potential of ERCEs as tools for cell therapy.
The position is available immediately in San Diego, California in the laboratory of Dr. David M. Gilbert, Professor. There is flexibility to accommodate thesis defenses, publication timelines, and other standard career transitions.
Research Focus
Primary system: a hybrid CAST×129 pluripotent stem cell culture model optimized for ERCE discovery and functional testing.
Extensions: flexibility to pursue human ESCs and engineered cellular models. Initial thrust: a high‑throughput ERCE activity screen to identify sequences capable of manipulating replication timing, with the broader aim of defining biological significance and translational potential.
Variant mining: discovery of ERCE variants associated with phenotypic and disease traits, in conjunction with other research collaborators.
Mentoring & Career Development
Close one‑on‑one mentorship in experimental design, manuscript and grant preparation, and strategic career planning.
Active integration into collaborative networks and project leadership opportunities.
Minimum Requirements
Ph.D. (or M.D./Ph.D.) in molecular biology, genomics, epigenetics, computational biology, or a related field.
Demonstrated expertise in one or more of: genome engineering, functional genomics, epigenome/replication profiling, single‑cell methods, or regulatory sequence analysis. Strong record of productivity, scientific rigor, and a collaborative mindset. Ambition to build an independent program centered on replication timing and ERCE biology.
Salary Range $70,500 – $72,500
Benefits San Diego BioMed offers a competitive benefits package, including medical, dental, vision, life insurance, long‑term disability, paid time off, and a generous employer match to the retirement plan. The work environment at San Diego BioMed is one that fosters and promotes collaboration and inclusivity.
Applying for the Position
CV
Brief cover letter describing how your career goals align with this position
Names, affiliations, and contact information (email and phone) for at least three references (include in cover letter)
San Diego BioMed is committed to a policy of equal employment opportunity in regard to recruiting, hiring, training and promoting the most qualified individuals, without regard to race, color, creed, religion, sex, sexual orientation, gender, gender identity and expression, marital status, age, registered domestic partner status, national origin or ancestry, physical or mental disability, age, disability, protected veteran status, medical condition including genetic characteristics, or any other protected status as designed by federal, state, or local law.
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