e184
Science Team Lead - Epigenetic reprogramming
e184 is a biotechnology research company advancing in vitro gametogenesis to transform reproductive medicine. We’re developing integrated platforms that combine cellular reprogramming, machine learning‑guided optimization, multi‑omics analysis, and automated experimental workflows to enable gamete development for individuals facing reproductive challenges. We’re assembling interdisciplinary teams across cell and molecular engineering, synthetic biology, epigenetic editing, bioinformatics, and computational biology to tackle one of biology’s most impactful problems – returning the fundamental right to procreate.
Role overview We are seeking a
Science Team Lead
to drive our innovative research program developing advanced epigenetic editing technologies for therapeutic applications. This is a leadership position reporting directly to the
Chief Scientific Officer (CSO) . The successful candidate will guide scientific planning, supervise project execution, contribute to team building, and shape the long‑term R&D roadmap. This is a
hands‑on role : in addition to team leadership and project management, the candidate will be directly involved in
designing and conducting experiments , especially in early stages of the program.
What you will do
Lead a focused research team of 4-6 scientists and report directly to the CSO
Design and personally conduct experiments in DNA methylation editor optimization and validation
Develop guide RNA libraries targeting chromatin regulatory regions
Establish protocols for targeted methylation editing with persistence validation through cell divisions
Create delivery strategies for enhanced efficiency in challenging cell types
Execute single and multiplex editing approaches with maintained specificity across targets
Drive progression from cell culture proof‑of‑concept to functional validation in mammalian models
Define research approaches and priorities aligned with company objectives
Drive scientific output, IP development, and milestone achievement within established timelines
Required qualifications
PhD in
Molecular Biology ,
Epigenetics ,
Developmental Biology , or related field
Minimum 5 years postdoctoral or industry experience in epigenetic editing, chromatin modification, or CRISPR‑based technologies
Hands‑on experience with guide RNA design and validation for chromatin targets
Advanced skills in DNA methylation and chromatin modification analysis
Knowledge of chromatin biology, gene regulation, and epigenetic inheritance mechanisms
Experience leading research teams while maintaining significant hands‑on involvement
Preferred qualifications
Experience with allele‑specific epigenetic editing approaches
Track record of integrating innovative experimental and computational approaches in epigenetic editing with publications in high‑impact journals and experience in IP development
Familiarity with mammalian reproduction models and developmental biology applications
What we offer
On‑site work
in the US Pacific Northwest in a state‑of‑the‑art facility
Competitive compensation, equity participation, and comprehensive benefits
Collaborative and supportive culture with mission‑driven colleagues focused on breakthrough discoveries
Opportunity to build a pioneering technology platform with high therapeutic potential
Disclaimer The above job description is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of e184.
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Role overview We are seeking a
Science Team Lead
to drive our innovative research program developing advanced epigenetic editing technologies for therapeutic applications. This is a leadership position reporting directly to the
Chief Scientific Officer (CSO) . The successful candidate will guide scientific planning, supervise project execution, contribute to team building, and shape the long‑term R&D roadmap. This is a
hands‑on role : in addition to team leadership and project management, the candidate will be directly involved in
designing and conducting experiments , especially in early stages of the program.
What you will do
Lead a focused research team of 4-6 scientists and report directly to the CSO
Design and personally conduct experiments in DNA methylation editor optimization and validation
Develop guide RNA libraries targeting chromatin regulatory regions
Establish protocols for targeted methylation editing with persistence validation through cell divisions
Create delivery strategies for enhanced efficiency in challenging cell types
Execute single and multiplex editing approaches with maintained specificity across targets
Drive progression from cell culture proof‑of‑concept to functional validation in mammalian models
Define research approaches and priorities aligned with company objectives
Drive scientific output, IP development, and milestone achievement within established timelines
Required qualifications
PhD in
Molecular Biology ,
Epigenetics ,
Developmental Biology , or related field
Minimum 5 years postdoctoral or industry experience in epigenetic editing, chromatin modification, or CRISPR‑based technologies
Hands‑on experience with guide RNA design and validation for chromatin targets
Advanced skills in DNA methylation and chromatin modification analysis
Knowledge of chromatin biology, gene regulation, and epigenetic inheritance mechanisms
Experience leading research teams while maintaining significant hands‑on involvement
Preferred qualifications
Experience with allele‑specific epigenetic editing approaches
Track record of integrating innovative experimental and computational approaches in epigenetic editing with publications in high‑impact journals and experience in IP development
Familiarity with mammalian reproduction models and developmental biology applications
What we offer
On‑site work
in the US Pacific Northwest in a state‑of‑the‑art facility
Competitive compensation, equity participation, and comprehensive benefits
Collaborative and supportive culture with mission‑driven colleagues focused on breakthrough discoveries
Opportunity to build a pioneering technology platform with high therapeutic potential
Disclaimer The above job description is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of e184.
#J-18808-Ljbffr