CytomX Therapeutics, Inc.
TEMP Scientist I, Bioconjugation
CytomX Therapeutics, Inc., San Francisco, California, United States, 94199
Headquarters Location:
South San Francisco, CA Candidate Location:
Hybrid Travel Required:
None Reports To:
Senior Scientist II, Protein Sciences & Early CMC Department:
Protein Sciences Position Type:
Temporary (12 months), Non‑Exempt About CytomX Therapeutics:
CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel PROBODY® therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX’s robust and differentiated pipeline comprises therapeutic candidates across multiple treatment modalities including antibody‑drug conjugates (“ADCs”), T‑cell engagers, and immune modulators such as cytokines. CytomX’s clinical‑stage pipeline includes CX‑2051 and CX‑801. Learn more at www.cytomx.com. Who You Are and What You’ll Do:
We seek a highly motivated individual with strong chemistry and biologics background to evaluate the drug conjugate technologies to generate cutting‑edge PROBODY drug conjugates for the treatment of multiple cancer indications. The successful candidate will work as a TEMP Scientist I for 12 months in the Protein Sciences & Early CMC Department and contribute to the development of robust research‑scale conjugation process and innovative protein production and purification strategies to support multiple discovery programs. The individual will have the opportunity to work closely with Process Sciences group to transition PROBODY drug conjugates into clinical development and provide support for ongoing clinical programs. Job Responsibilities:
Generate PROBODY drug conjugates (PDC) to support all discovery PDC programs at CytomX. Develop robust research‑scale conjugation process for various random and site‑specific conjugation technologies. Develop analytical methods to fully characterize PDCs. Develop analytical methods for in‑process testing of PDCs. Develop strategies to improve the production, purification and characterization of various formats of PROBODY molecules. Work collaboratively with members of Oncology Research and provide technical and scientific guidance. Work collaboratively with Process Sciences group to transition the conjugation process and analytics from discovery to development and support ongoing programs. Collaborate with discovery, protein engineering and pharmacology to provide therapeutic protein candidates of appropriate quality for use in in‑vitro and in‑vivo studies. Organize data and communicate results in internal and external scientific meetings. Minimum Qualifications:
PhD in Biochemistry or Chemistry or related discipline with 2+ years of experience in the biotechnology or biopharma industry OR MS in Biochemistry or Chemistry with 5+ years of experience in the biotechnology or biopharma industry. Experience with conjugation chemistry used in ADC discovery is required. Expertise in developing high‑throughput conjugation methods is required. Experience in bioconjugation methods (lysine, inter‑chain cysteine and/or site‑specific cysteine and other) is required. Experience in synthesis, purification and characterization of ADCs on research scales (0.5 – 15 mg) and medium scales (100 – 500 mg) is required. Experience in development of purification strategies to separate conjugated and unconjugated proteins and antibodies using various chromatographic techniques and pertinent filtration processes is required. Expertise in analytical and biophysical characterization of ADCs including HIC, SEC, RP‑HPLC, CE‑SDS, and ELISA is required. Must have strong communication (oral and written) and presentation skills. Preferred Qualifications:
Experience with ADC process development preferred. Experience with Linker‑payload synthesis chemistry preferred. Experience in transitioning the ADCs from discovery to Development is preferred. Experience in the production and purification of antibodies and bispecific molecules in various formats preferred. Experience in developing and executing procedures and protocols and preparing summary reports preferred. How You Will Work:
Demonstrates collaboration and teamwork. Works well with others and understands that collaboration leads to better results. Possesses strong communication skills. Communicates clearly, concisely, and professionally. Listens actively to build understanding. Excellent leadership and influencing skills. Exhibits strong interpersonal skills and self‑awareness. Builds and cultivates strong and enduring relationships with others. Acts with humility and understands own strengths and weaknesses. Shows continuous improvement and a commitment to self‑management and development. Operates with a continuous improvement mindset and continuously seeks to expand own knowledge and capabilities. Adaptable and resilient with problem‑solving orientation. Demonstrates a patient focus. Puts the patient first in actions and decisions taken. Intellectually curious, enthusiastic, creative. Compensation, Benefits, and So Much More:
The expected salary range for this role based on the primary location for this position in the SF Bay Area in California is $57.00 – $67.00 per hour. Offer amounts are determined by factors such as experience, qualifications, geographic location, and other job‑related factors permitted by law. A great environment where we work collaboratively, leverage each other’s strengths, and work toward a shared vision with our common goals of doing the best thing for patients. A robust and enduring approach to your development and career growth fueled by a strong learning curriculum and career guidance that helps you understand how you can grow your career at CytomX. A robust and highly competitive total rewards program that helps you achieve your compensation goals while supporting a great work/life balance for permanent employees only. Conditions of Employment:
Background investigations are required for all positions at CytomX, consistent with applicable law. CytomX’s Commitment to Diversity, Equity, Inclusion, and Belonging (DEIB):
CytomX believes that DEIB helps drive our success, and we encourage candidates from all identities, backgrounds, and abilities to apply. We are an equal opportunity employer committed to building an inclusive, innovative work environment with employees who reflect our values and ultimately, serve our patients. Therefore, in all aspects of the employment process, we provide employment opportunities to all qualified applicants without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity or expression, pregnancy, medical condition related to pregnancy, creed, ancestry, national origin, marital status, genetic information, or military status, or any other protected status in accordance with applicable law. Further, we are committed to the full inclusion of all qualified individuals. As part of this commitment, we will assist individuals who have a disability with any reasonable accommodation requests related to employment, including completing the application process, interviewing, completing any pre‑employment testing, participating in the employee selection process, and/or performing essential job functions where the requested accommodation does not impose an undue hardship. If you have a disability and require reasonable accommodation, or need other assistance in applying for or interviewing for this position, please direct your inquiries to Human Resources at hr@cytomx.com. Notice to Recruiters/Staffing Agencies:
Recruiters and staffing agencies should not contact CytomX Therapeutics through this page. We require that all Recruitment Vendors (e.g., search firms, recruitment agencies and staffing companies) have a fully executed, formal written agreement on file with CytomX prior to submitting candidates. Any resumes submitted through the website or directly by Recruitment Vendors will be considered unsolicited. Unsolicited vendor submissions do not constitute any actual or implied contract with CytomX, and CytomX will not be responsible for any purported fees. For more information, please contact our HR team at hr@cytomx.com. Applicant Personal Information Processing Notice:
Please review our Applicant Personal Information Processing Notice to understand what types of personal information we collect from job applicants and why we process such information.
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South San Francisco, CA Candidate Location:
Hybrid Travel Required:
None Reports To:
Senior Scientist II, Protein Sciences & Early CMC Department:
Protein Sciences Position Type:
Temporary (12 months), Non‑Exempt About CytomX Therapeutics:
CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel PROBODY® therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX’s robust and differentiated pipeline comprises therapeutic candidates across multiple treatment modalities including antibody‑drug conjugates (“ADCs”), T‑cell engagers, and immune modulators such as cytokines. CytomX’s clinical‑stage pipeline includes CX‑2051 and CX‑801. Learn more at www.cytomx.com. Who You Are and What You’ll Do:
We seek a highly motivated individual with strong chemistry and biologics background to evaluate the drug conjugate technologies to generate cutting‑edge PROBODY drug conjugates for the treatment of multiple cancer indications. The successful candidate will work as a TEMP Scientist I for 12 months in the Protein Sciences & Early CMC Department and contribute to the development of robust research‑scale conjugation process and innovative protein production and purification strategies to support multiple discovery programs. The individual will have the opportunity to work closely with Process Sciences group to transition PROBODY drug conjugates into clinical development and provide support for ongoing clinical programs. Job Responsibilities:
Generate PROBODY drug conjugates (PDC) to support all discovery PDC programs at CytomX. Develop robust research‑scale conjugation process for various random and site‑specific conjugation technologies. Develop analytical methods to fully characterize PDCs. Develop analytical methods for in‑process testing of PDCs. Develop strategies to improve the production, purification and characterization of various formats of PROBODY molecules. Work collaboratively with members of Oncology Research and provide technical and scientific guidance. Work collaboratively with Process Sciences group to transition the conjugation process and analytics from discovery to development and support ongoing programs. Collaborate with discovery, protein engineering and pharmacology to provide therapeutic protein candidates of appropriate quality for use in in‑vitro and in‑vivo studies. Organize data and communicate results in internal and external scientific meetings. Minimum Qualifications:
PhD in Biochemistry or Chemistry or related discipline with 2+ years of experience in the biotechnology or biopharma industry OR MS in Biochemistry or Chemistry with 5+ years of experience in the biotechnology or biopharma industry. Experience with conjugation chemistry used in ADC discovery is required. Expertise in developing high‑throughput conjugation methods is required. Experience in bioconjugation methods (lysine, inter‑chain cysteine and/or site‑specific cysteine and other) is required. Experience in synthesis, purification and characterization of ADCs on research scales (0.5 – 15 mg) and medium scales (100 – 500 mg) is required. Experience in development of purification strategies to separate conjugated and unconjugated proteins and antibodies using various chromatographic techniques and pertinent filtration processes is required. Expertise in analytical and biophysical characterization of ADCs including HIC, SEC, RP‑HPLC, CE‑SDS, and ELISA is required. Must have strong communication (oral and written) and presentation skills. Preferred Qualifications:
Experience with ADC process development preferred. Experience with Linker‑payload synthesis chemistry preferred. Experience in transitioning the ADCs from discovery to Development is preferred. Experience in the production and purification of antibodies and bispecific molecules in various formats preferred. Experience in developing and executing procedures and protocols and preparing summary reports preferred. How You Will Work:
Demonstrates collaboration and teamwork. Works well with others and understands that collaboration leads to better results. Possesses strong communication skills. Communicates clearly, concisely, and professionally. Listens actively to build understanding. Excellent leadership and influencing skills. Exhibits strong interpersonal skills and self‑awareness. Builds and cultivates strong and enduring relationships with others. Acts with humility and understands own strengths and weaknesses. Shows continuous improvement and a commitment to self‑management and development. Operates with a continuous improvement mindset and continuously seeks to expand own knowledge and capabilities. Adaptable and resilient with problem‑solving orientation. Demonstrates a patient focus. Puts the patient first in actions and decisions taken. Intellectually curious, enthusiastic, creative. Compensation, Benefits, and So Much More:
The expected salary range for this role based on the primary location for this position in the SF Bay Area in California is $57.00 – $67.00 per hour. Offer amounts are determined by factors such as experience, qualifications, geographic location, and other job‑related factors permitted by law. A great environment where we work collaboratively, leverage each other’s strengths, and work toward a shared vision with our common goals of doing the best thing for patients. A robust and enduring approach to your development and career growth fueled by a strong learning curriculum and career guidance that helps you understand how you can grow your career at CytomX. A robust and highly competitive total rewards program that helps you achieve your compensation goals while supporting a great work/life balance for permanent employees only. Conditions of Employment:
Background investigations are required for all positions at CytomX, consistent with applicable law. CytomX’s Commitment to Diversity, Equity, Inclusion, and Belonging (DEIB):
CytomX believes that DEIB helps drive our success, and we encourage candidates from all identities, backgrounds, and abilities to apply. We are an equal opportunity employer committed to building an inclusive, innovative work environment with employees who reflect our values and ultimately, serve our patients. Therefore, in all aspects of the employment process, we provide employment opportunities to all qualified applicants without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity or expression, pregnancy, medical condition related to pregnancy, creed, ancestry, national origin, marital status, genetic information, or military status, or any other protected status in accordance with applicable law. Further, we are committed to the full inclusion of all qualified individuals. As part of this commitment, we will assist individuals who have a disability with any reasonable accommodation requests related to employment, including completing the application process, interviewing, completing any pre‑employment testing, participating in the employee selection process, and/or performing essential job functions where the requested accommodation does not impose an undue hardship. If you have a disability and require reasonable accommodation, or need other assistance in applying for or interviewing for this position, please direct your inquiries to Human Resources at hr@cytomx.com. Notice to Recruiters/Staffing Agencies:
Recruiters and staffing agencies should not contact CytomX Therapeutics through this page. We require that all Recruitment Vendors (e.g., search firms, recruitment agencies and staffing companies) have a fully executed, formal written agreement on file with CytomX prior to submitting candidates. Any resumes submitted through the website or directly by Recruitment Vendors will be considered unsolicited. Unsolicited vendor submissions do not constitute any actual or implied contract with CytomX, and CytomX will not be responsible for any purported fees. For more information, please contact our HR team at hr@cytomx.com. Applicant Personal Information Processing Notice:
Please review our Applicant Personal Information Processing Notice to understand what types of personal information we collect from job applicants and why we process such information.
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