Alnylam Pharmaceuticals
Principal Scientist, Ligand Binding & Molecular Bioanalysis [Lab-Based]
Alnylam Pharmaceuticals, Cambridge, Massachusetts, us, 02140
Principal Scientist, Ligand Binding & Molecular Bioanalysis [Lab-Based]
Join Alnylam Pharmaceuticals as a Principal Scientist in the Bioanalytical Sciences group to develop and implement fit‑for‑purpose methods across diverse ligand binding and molecular platforms. Your work will support the bioanalysis of proteins, peptides, antibodies, RNA, and oligonucleotides to inform target engagement of new chemistries and delivery modalities across preclinical species and biological matrices.
You will work in a matrixed environment, partnering closely with Investigative Sciences, Research and Chemistry leads to establish and advance internal bioanalytical assays for emerging tissues. By analyzing and interpreting results, you will help drive critical insights into mechanism of action, safety and efficacy, directly shaping decision‑making in RNAi therapeutic development.
You have a strong foundation in biochemistry and molecular biology, a proven ability to thrive in fast‑paced, high‑intensity, time‑sensitive environments, and you are a creative problem solver and effective communicator in collaborative, team‑oriented settings.
This position is onsite and will be primarily located in Cambridge, MA.
Key Responsibilities
Apply expertise and innovative problem‑solving to design, optimize, and troubleshoot ligand binding (ELISA, MSD, Quanterix SIMOA, ARGO NULISA) and molecular assays (ddPCR, qPCR), adapting methods creatively for complex preclinical models and biological matrices
Repurpose existing methods to support rapid sample analysis, leveraging comparisons to historical data to inform next steps for platform optimization and delivery advancement
Provide subject‑matter expertise in ligand binding and molecular assays, with deep understanding of technologies and applications to assess strengths and limitations
Synthesize internal and published data to inform assay execution
Create training materials and SOPs; mentor analysts and drive successful internal/external method transfers with defined acceptance criteria
Collaborate with cross‑functional teams within Research and Development to align on projects and timelines, and provide scientific oversight on bioanalytical data that support context of use
Identify, assess, and implement cutting‑edge technologies to strengthen assay performance, expand technical capabilities, and improve operational efficiency
Maintain laboratory notebooks, perform data analysis and QC, and communicate results to cross‑functional teams and external science forums
Qualifications
Ph.D. in Biochemistry, Molecular/Cell Biology, or related field with 5+ years of relevant industry experience; or exceptional M.S. with 8+ years of experience
In‑depth knowledge and hands‑on expertise with ligand binding platforms (ELISA, MSD, Quanterix) and molecular platforms (Applied Biosystems/Bio‑Rad)
Familiarity with discovery‑based platforms (OLINK, OpenArray, QuantiGene) is a plus
Proficient in Microsoft Office (Excel, Word, PowerPoint) and skilled with specialized analytical platforms (GraphPad Prism, SoftMax Pro, Discovery Workbench, QuantStudio) to support data analysis, visualization, and reporting
Strong understanding of disease biology and the drug development process, enabling the design and implementation of fit‑for‑purpose assays
Self‑motivated, detail‑oriented, and highly organized, with the ability to manage multiple projects in a fast‑paced, collaborative environment
Demonstrated track record of scientific communication, including conference presentations, peer‑reviewed publications, and/or regulatory or industry white papers
Excellent interpersonal, verbal, and written communication skills to support effective cross‑functional collaboration
U.S. Pay Range $148,200.00 - $208,800.00
The pay range reflects the full‑time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short‑term incentive award (e.g., bonus or sales incentive) and an annual long‑term incentive award (e.g., equity).
Alnylam’s robust Total Rewards package is designed to support your overall health and well‑being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k) with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company‑wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well‑being reflects our belief that caring for our people fuels the impact we create together.
About Alnylam We are the leader in RNAi therapeutics–a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize‑winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late‑stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We’re proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
Equal Opportunity Statement At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E‑Verify Employer.
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You will work in a matrixed environment, partnering closely with Investigative Sciences, Research and Chemistry leads to establish and advance internal bioanalytical assays for emerging tissues. By analyzing and interpreting results, you will help drive critical insights into mechanism of action, safety and efficacy, directly shaping decision‑making in RNAi therapeutic development.
You have a strong foundation in biochemistry and molecular biology, a proven ability to thrive in fast‑paced, high‑intensity, time‑sensitive environments, and you are a creative problem solver and effective communicator in collaborative, team‑oriented settings.
This position is onsite and will be primarily located in Cambridge, MA.
Key Responsibilities
Apply expertise and innovative problem‑solving to design, optimize, and troubleshoot ligand binding (ELISA, MSD, Quanterix SIMOA, ARGO NULISA) and molecular assays (ddPCR, qPCR), adapting methods creatively for complex preclinical models and biological matrices
Repurpose existing methods to support rapid sample analysis, leveraging comparisons to historical data to inform next steps for platform optimization and delivery advancement
Provide subject‑matter expertise in ligand binding and molecular assays, with deep understanding of technologies and applications to assess strengths and limitations
Synthesize internal and published data to inform assay execution
Create training materials and SOPs; mentor analysts and drive successful internal/external method transfers with defined acceptance criteria
Collaborate with cross‑functional teams within Research and Development to align on projects and timelines, and provide scientific oversight on bioanalytical data that support context of use
Identify, assess, and implement cutting‑edge technologies to strengthen assay performance, expand technical capabilities, and improve operational efficiency
Maintain laboratory notebooks, perform data analysis and QC, and communicate results to cross‑functional teams and external science forums
Qualifications
Ph.D. in Biochemistry, Molecular/Cell Biology, or related field with 5+ years of relevant industry experience; or exceptional M.S. with 8+ years of experience
In‑depth knowledge and hands‑on expertise with ligand binding platforms (ELISA, MSD, Quanterix) and molecular platforms (Applied Biosystems/Bio‑Rad)
Familiarity with discovery‑based platforms (OLINK, OpenArray, QuantiGene) is a plus
Proficient in Microsoft Office (Excel, Word, PowerPoint) and skilled with specialized analytical platforms (GraphPad Prism, SoftMax Pro, Discovery Workbench, QuantStudio) to support data analysis, visualization, and reporting
Strong understanding of disease biology and the drug development process, enabling the design and implementation of fit‑for‑purpose assays
Self‑motivated, detail‑oriented, and highly organized, with the ability to manage multiple projects in a fast‑paced, collaborative environment
Demonstrated track record of scientific communication, including conference presentations, peer‑reviewed publications, and/or regulatory or industry white papers
Excellent interpersonal, verbal, and written communication skills to support effective cross‑functional collaboration
U.S. Pay Range $148,200.00 - $208,800.00
The pay range reflects the full‑time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short‑term incentive award (e.g., bonus or sales incentive) and an annual long‑term incentive award (e.g., equity).
Alnylam’s robust Total Rewards package is designed to support your overall health and well‑being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k) with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company‑wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well‑being reflects our belief that caring for our people fuels the impact we create together.
About Alnylam We are the leader in RNAi therapeutics–a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize‑winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late‑stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We’re proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
Equal Opportunity Statement At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E‑Verify Employer.
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