TRexBio
Senior Scientist, Bioanalytical, Pharmacokinetics, and Immunology Assays
TRexBio, South San Francisco, California, us, 94083
Senior Scientist, Bioanalytical, Pharmacokinetics, and Immunology Assays
Location: South San Francisco, CA
Position Summary We are seeking a Senior Scientist with strong expertise in pharmacokinetic (PK) assay development and hands‑on experience with protein and biomarker assays. The ideal candidate will bring proven skills across immunoassay platforms, as well as familiarity with immune cell surface marker analysis. This role offers the opportunity to directly impact the advancement of our therapeutic pipeline by connecting preclinical studies to mechanism of action and translational outcomes.
Key Responsibilities
Design, develop, and execute assays to support PK/PD package of preclinical programs
Develop and optimize bioanalytical assays to quantify therapeutic proteins and biomarkers (e.g., ELISA, MSD)
Apply immunological techniques (e.g., flow cytometry, multiplex cytokine profiling) to characterize surface markers and immune cell states
Interpret and present data to cross‑functional teams, contributing to dose‑response and exposure–response modeling
Collaborate closely with discovery biology, in vivo pharmacology, and computational groups to advance pipeline candidates
Provide subject matter expertise in assay design, validation, and troubleshooting
Mentor junior scientists and contribute to team growth and best practices
Maintain detailed records in compliance with industry standards; support preparation of data packages for internal reviews and external partners
Required Qualifications
PhD in Immunology, Pharmacology, Biochemistry, or a related discipline with 3+ years of postdoctoral or industry experience; OR MS with 7+ years of biotech/pharma experience
Demonstrated expertise in bioanalytical assay development for therapeutic proteins
Strong technical proficiency across immunoassay platforms and immune profiling techniques (e.g., ELISA, MSD, and flow cytometry)
Familiarity with immune cell surface marker analysis and characterization
Strong data analysis skills with the ability to communicate findings clearly across disciplines
Proven ability to work effectively in collaborative, fast‑paced environments
Experience with regulatory assay validation (GLP/GCLP) desirable but not required
Compensation: $130,000 – $160,000 per year, plus discretionary bonus.
Our Culture At TRexBio, you will have the opportunity to work with amazingly smart humans who strive to make the world a better place. Our team‑centric culture values individual creativity, celebrates successes, and fosters supportive, collaborative interactions across the organization.
TRexBio Company Overview TRexBio is a clinical‑stage biotechnology company leveraging cutting‑edge computational biology tools, a focus on human tissue, and expertise in immunobiology to develop revolutionary therapeutics for inflammatory diseases. Our powerful ‘deep biology’ discovery engine maps human tissue Treg behavior to disease processes, enabling the identification and characterization of novel therapeutic targets. We build a broad portfolio of novel therapies that modulate the immune system to restore human tissue immune homeostasis.
EEO Statement TRexBio is proud to be an AA/EEO employer and all qualified candidates will receive consideration without regard to characteristics protected by applicable local, state, or federal law, such as race, color, sex, age, religion, national origin, physical or mental disability, pregnancy, marital status, veteran or military status, genetic information, or sexual orientation.
Seniority Level Mid‑Senior level
Employment Type Full‑time
Job Function Research
#J-18808-Ljbffr
Position Summary We are seeking a Senior Scientist with strong expertise in pharmacokinetic (PK) assay development and hands‑on experience with protein and biomarker assays. The ideal candidate will bring proven skills across immunoassay platforms, as well as familiarity with immune cell surface marker analysis. This role offers the opportunity to directly impact the advancement of our therapeutic pipeline by connecting preclinical studies to mechanism of action and translational outcomes.
Key Responsibilities
Design, develop, and execute assays to support PK/PD package of preclinical programs
Develop and optimize bioanalytical assays to quantify therapeutic proteins and biomarkers (e.g., ELISA, MSD)
Apply immunological techniques (e.g., flow cytometry, multiplex cytokine profiling) to characterize surface markers and immune cell states
Interpret and present data to cross‑functional teams, contributing to dose‑response and exposure–response modeling
Collaborate closely with discovery biology, in vivo pharmacology, and computational groups to advance pipeline candidates
Provide subject matter expertise in assay design, validation, and troubleshooting
Mentor junior scientists and contribute to team growth and best practices
Maintain detailed records in compliance with industry standards; support preparation of data packages for internal reviews and external partners
Required Qualifications
PhD in Immunology, Pharmacology, Biochemistry, or a related discipline with 3+ years of postdoctoral or industry experience; OR MS with 7+ years of biotech/pharma experience
Demonstrated expertise in bioanalytical assay development for therapeutic proteins
Strong technical proficiency across immunoassay platforms and immune profiling techniques (e.g., ELISA, MSD, and flow cytometry)
Familiarity with immune cell surface marker analysis and characterization
Strong data analysis skills with the ability to communicate findings clearly across disciplines
Proven ability to work effectively in collaborative, fast‑paced environments
Experience with regulatory assay validation (GLP/GCLP) desirable but not required
Compensation: $130,000 – $160,000 per year, plus discretionary bonus.
Our Culture At TRexBio, you will have the opportunity to work with amazingly smart humans who strive to make the world a better place. Our team‑centric culture values individual creativity, celebrates successes, and fosters supportive, collaborative interactions across the organization.
TRexBio Company Overview TRexBio is a clinical‑stage biotechnology company leveraging cutting‑edge computational biology tools, a focus on human tissue, and expertise in immunobiology to develop revolutionary therapeutics for inflammatory diseases. Our powerful ‘deep biology’ discovery engine maps human tissue Treg behavior to disease processes, enabling the identification and characterization of novel therapeutic targets. We build a broad portfolio of novel therapies that modulate the immune system to restore human tissue immune homeostasis.
EEO Statement TRexBio is proud to be an AA/EEO employer and all qualified candidates will receive consideration without regard to characteristics protected by applicable local, state, or federal law, such as race, color, sex, age, religion, national origin, physical or mental disability, pregnancy, marital status, veteran or military status, genetic information, or sexual orientation.
Seniority Level Mid‑Senior level
Employment Type Full‑time
Job Function Research
#J-18808-Ljbffr