St. Jude Children's Research Hospital
Bioinformatics Research Scientist or Senior Computational Researcher
St. Jude Children's Research Hospital, Memphis, Tennessee, us, 37544
Bioinformatics Research Scientist or Senior Computational Researcher
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Bioinformatics Research Scientist or Senior Computational Researcher
role at
St. Jude Children's Research Hospital
Join an excellent team of researchers dedicated to coming closer to the mission of St. Jude Children's Research Hospital, that no child will die at the dawn of life. The Computational and Structural Biology Center (CSBC) in the Center of Excellence for Data-Driven Discovery (C3D) of the Department seeks a skilled and highly motivated Senior Bioinformatics Research Scientist. The CSBC is the collaborative interface of the C3D, working with St. Jude researchers campus-wide to disseminate and implement the computational technological developments of the C3D.
As a Senior Computational Researcher (S18) or Bioinformatics Research Scientist (S19) in the CSBC, you will play a pivotal role in the ligand discovery team, led by Dr. Christoph Gorgulla. You will be the first team member in the CBSC focused on ligand discovery, joining a team of dedicated computational researchers with diverse expertise ranging from structural bioinformatics to machine learning and AI. Your primary mission will be to work with other groups and researchers across St. Jude to implement our technologies to identify novel hit/lead compounds for the treatment of various diseases. You will work with them to optimize any results, working to obtain new tool compounds and drug candidates. Leveraging state-of-the-art computational methods, including structure‑based ultra‑large virtual screenings, (quantum and classical) free‑energy simulations, and machine‑learning techniques, you will contribute to groundbreaking research in the field. The primary ligand discovery platform that we will be using is the VirtualFlow ultra‑large virtual screening platform. Collaboration is at the heart of this role, and you will closely collaborate with other computational and wet‑lab colleagues who validate and experimentally verify the predicted hit and lead compounds. By working together in a collaborative and intellectually stimulating environment, you will have the opportunity to contribute to a large number of ligand/drug discovery projects and make a lasting impact on the lives of children fighting cancer and other life‑threatening diseases. The successful candidate will have the opportunity to lead collaborative projects, mentor junior scientists and students, and contribute to high‑impact publications.
Job Responsibilities
Independently perform basic and advanced level statistical analysis, algorithm implementation, programming from a variety of biotechnology platforms, and oversee quality check.
Design and prepare materials and courses for training on various bioinformatics software and databases, computing, data mining, and analysis.
Act as a liaison between end‑users, software developers, system designers, and different departments.
Establish protocols or best practices for common research tasks and SOP, evaluate products and solutions to make recommendations, and integrate solutions.
Lead the development, implementation, installation, and maintenance of databases; coordinate data collection, database implementation, and usage and any hardware and software related to database collection.
Develop programs to assist in the analysis of data within the databases.
Assist in planning, coordinating, and organizing projects across departments and delegate tasks based on priority, expertise, and capacity.
Perform other duties as assigned to meet the goals and objectives of the department and institution.
Maintain regular and predictable attendance.
Minimum Education and/or Training
Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field.
Master's degree or PhD preferred.
Minimum Experience
Minimum Requirement: Bachelor's degree with 6+ years of relevant post‑degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry).
Experience Exception: Master's degree with 4+ years of relevant post‑degree experience (OR) PhD with no experience.
Experience in at least one programming or scripting language and at least one statistical package, with R preferred.
About St. Jude St. Jude Children’s Research Hospital is a world‑class research institution dedicated to pediatric cancer and other catastrophic diseases of childhood. The first and only National Cancer Institute (NCI)‑designated Comprehensive Cancer Center devoted solely to children. Our 300 faculty work across the spectrum of basic, translational, clinical, and population science in a highly collaborative multidisciplinary environment that includes a Nobel laureate and members of the National Academy of Science and the National Academy of Medicine. St. Jude is ranked on Fortune Magazine’s “Best Workplaces in Health Care & Biopharma” and Glassdoor’s “Best Places to Work”. St. Jude is one of the best‑funded research institutes in the US with an annual budget of over $2 billion per year ( source ).
What We Will Offer You
Mission and Purpose: At St. Jude, working is more than just a job — it’s a calling. Each member of St. Jude is united by a shared purpose: finding cures and saving children.
Community and Belonging: St. Jude is like a warm family that welcomes you.
The Best of Both Worlds – Industry and Academia: St. Jude provides academic freedom in research and industrial efficiency and resources.
World‑Class Benefits: St. Jude offers a world‑class benefits package. Enjoy comprehensive healthcare, a competitive salary, tuition assistance for continued education, and exceptional work‑life balance with ample paid time off.
Professional Growth: You will have access to opportunities to enhance your professional growth in terms of scientific skills, soft skills, and your career.
Diversity: St. Jude is dedicated to fostering an inclusive and diverse scientific community, where everyone’s contributions are valued.
Competitive Compensation: Embark on your journey with a competitive salary (depending on experience) comprehensive benefits and generous relocation assistance, reflecting our commitment to recognize and invest in talent. Furthermore, in Memphis/Tennessee, there is no income tax.
Top Employer: St. Jude was among the top 10 large employers in the US in 2024, ahead of Google, Microsoft and Apple.
Personalized Guidance: Dr. Gorgulla is committed to providing hands‑on mentorship tailored to your needs and career aspirations.
Modern Buildings and Spaces: Our research group and wet lab is located in the newest building of the campus, the Inspiration 4 – Advanced Research Center.
Additional Perks: St. Jude offers many special perks, such as an on‑site gym, an employee pharmacy, and many others.
Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. A reasonable estimate of the current salary range is $78,000 - $139,360 per year for the role of Bioinformatics Research Scientist or Senior Computational Researcher.
St. Jude is an Equal Opportunity Employer.
St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
#J-18808-Ljbffr
Bioinformatics Research Scientist or Senior Computational Researcher
role at
St. Jude Children's Research Hospital
Join an excellent team of researchers dedicated to coming closer to the mission of St. Jude Children's Research Hospital, that no child will die at the dawn of life. The Computational and Structural Biology Center (CSBC) in the Center of Excellence for Data-Driven Discovery (C3D) of the Department seeks a skilled and highly motivated Senior Bioinformatics Research Scientist. The CSBC is the collaborative interface of the C3D, working with St. Jude researchers campus-wide to disseminate and implement the computational technological developments of the C3D.
As a Senior Computational Researcher (S18) or Bioinformatics Research Scientist (S19) in the CSBC, you will play a pivotal role in the ligand discovery team, led by Dr. Christoph Gorgulla. You will be the first team member in the CBSC focused on ligand discovery, joining a team of dedicated computational researchers with diverse expertise ranging from structural bioinformatics to machine learning and AI. Your primary mission will be to work with other groups and researchers across St. Jude to implement our technologies to identify novel hit/lead compounds for the treatment of various diseases. You will work with them to optimize any results, working to obtain new tool compounds and drug candidates. Leveraging state-of-the-art computational methods, including structure‑based ultra‑large virtual screenings, (quantum and classical) free‑energy simulations, and machine‑learning techniques, you will contribute to groundbreaking research in the field. The primary ligand discovery platform that we will be using is the VirtualFlow ultra‑large virtual screening platform. Collaboration is at the heart of this role, and you will closely collaborate with other computational and wet‑lab colleagues who validate and experimentally verify the predicted hit and lead compounds. By working together in a collaborative and intellectually stimulating environment, you will have the opportunity to contribute to a large number of ligand/drug discovery projects and make a lasting impact on the lives of children fighting cancer and other life‑threatening diseases. The successful candidate will have the opportunity to lead collaborative projects, mentor junior scientists and students, and contribute to high‑impact publications.
Job Responsibilities
Independently perform basic and advanced level statistical analysis, algorithm implementation, programming from a variety of biotechnology platforms, and oversee quality check.
Design and prepare materials and courses for training on various bioinformatics software and databases, computing, data mining, and analysis.
Act as a liaison between end‑users, software developers, system designers, and different departments.
Establish protocols or best practices for common research tasks and SOP, evaluate products and solutions to make recommendations, and integrate solutions.
Lead the development, implementation, installation, and maintenance of databases; coordinate data collection, database implementation, and usage and any hardware and software related to database collection.
Develop programs to assist in the analysis of data within the databases.
Assist in planning, coordinating, and organizing projects across departments and delegate tasks based on priority, expertise, and capacity.
Perform other duties as assigned to meet the goals and objectives of the department and institution.
Maintain regular and predictable attendance.
Minimum Education and/or Training
Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field.
Master's degree or PhD preferred.
Minimum Experience
Minimum Requirement: Bachelor's degree with 6+ years of relevant post‑degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry).
Experience Exception: Master's degree with 4+ years of relevant post‑degree experience (OR) PhD with no experience.
Experience in at least one programming or scripting language and at least one statistical package, with R preferred.
About St. Jude St. Jude Children’s Research Hospital is a world‑class research institution dedicated to pediatric cancer and other catastrophic diseases of childhood. The first and only National Cancer Institute (NCI)‑designated Comprehensive Cancer Center devoted solely to children. Our 300 faculty work across the spectrum of basic, translational, clinical, and population science in a highly collaborative multidisciplinary environment that includes a Nobel laureate and members of the National Academy of Science and the National Academy of Medicine. St. Jude is ranked on Fortune Magazine’s “Best Workplaces in Health Care & Biopharma” and Glassdoor’s “Best Places to Work”. St. Jude is one of the best‑funded research institutes in the US with an annual budget of over $2 billion per year ( source ).
What We Will Offer You
Mission and Purpose: At St. Jude, working is more than just a job — it’s a calling. Each member of St. Jude is united by a shared purpose: finding cures and saving children.
Community and Belonging: St. Jude is like a warm family that welcomes you.
The Best of Both Worlds – Industry and Academia: St. Jude provides academic freedom in research and industrial efficiency and resources.
World‑Class Benefits: St. Jude offers a world‑class benefits package. Enjoy comprehensive healthcare, a competitive salary, tuition assistance for continued education, and exceptional work‑life balance with ample paid time off.
Professional Growth: You will have access to opportunities to enhance your professional growth in terms of scientific skills, soft skills, and your career.
Diversity: St. Jude is dedicated to fostering an inclusive and diverse scientific community, where everyone’s contributions are valued.
Competitive Compensation: Embark on your journey with a competitive salary (depending on experience) comprehensive benefits and generous relocation assistance, reflecting our commitment to recognize and invest in talent. Furthermore, in Memphis/Tennessee, there is no income tax.
Top Employer: St. Jude was among the top 10 large employers in the US in 2024, ahead of Google, Microsoft and Apple.
Personalized Guidance: Dr. Gorgulla is committed to providing hands‑on mentorship tailored to your needs and career aspirations.
Modern Buildings and Spaces: Our research group and wet lab is located in the newest building of the campus, the Inspiration 4 – Advanced Research Center.
Additional Perks: St. Jude offers many special perks, such as an on‑site gym, an employee pharmacy, and many others.
Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. A reasonable estimate of the current salary range is $78,000 - $139,360 per year for the role of Bioinformatics Research Scientist or Senior Computational Researcher.
St. Jude is an Equal Opportunity Employer.
St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
#J-18808-Ljbffr