Monte Rosa Therapeutics
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Scientist DMPK
role at
Monte Rosa Therapeutics .
Monte Rosa Therapeutics (MRT) seeks to recruit an experienced, creative and highly talented DMPK and ADME Scientist who is eager to assist in leading the discovery and development effort to grow the drug pipelines, as well as help lead external GxP compliance research efforts. The Scientist will work with MRTx colleagues to participate in all stages of DMPK and ADME assessments, from initial compound screening through to IND and NDA regulatory submissions. Working with Research, Bioanalytical and Clinical Science subject matter experts, the candidate will provide scientific expertise to ensure that clinical candidates with acceptable drug development characteristics are identified and appropriately characterized. The role represents Preclinical Development on Research and Development teams and regularly interfaces with internal and external colleagues to ensure timely and accurate dissemination of DMPK and ADME findings.
Pay Range Base pay range: $125,000.00/yr – $175,000.00/yr
Key Responsibilities
Work closely with the medicinal chemistry team to facilitate the non‑clinical development efforts in troubleshooting and guiding the discovery project team, focusing on optimizing properties for oral administration.
Represent Nonclinical Development to project teams and present our work in the interpretation of ADME experimental data related to in‑vitro and in‑vivo animal PK and biotransformation.
Continually learn in‑vitro ADME and in‑vivo animal PK analysis.
Coordinate outsourced in‑vitro and in‑vivo DMPK studies.
Explore new technologies and capabilities in the discovery DMPK space.
Strong written and oral communication to support internal communication of data, study reports and regulatory documentation.
Ability to work on multiple projects in a matrixed organizational structure.
Assist the Nonclinical Development & Clinical Pharmacology team’s activities across multiple project phases, including lead discovery, lead optimization, and regulatory filings.
Job Requirements
PhD/MS with 3+ years of drug discovery industry experience in Drug Metabolism, Pharmacokinetics, Pharmaceutical Chemistry, Toxicology, or a related scientific discipline.
Effective management of internal and external collaborations/service providers (CROs).
Build relationships with peers and partners outside of Nonclinical Development & Clinical Pharmacology to enable high team performance.
Demonstrates novel, innovative solutions to challenging problems using an extremely high degree of scientific discretion, intuition, and integrity.
Strong collaboration and innovative skills across subject areas representing DMPK as a project team representative within the core team.
Experience in the design, conduct, and interpretation of in‑vitro and in‑vivo ADME and animal PK studies.
Ability to work on site 100% is required.
Interested candidates may forward a CV and Cover Letter in a single PDF via our online portal:
https://www.monterosatx.com/careers/
Monte Rosa Therapeutics is a clinical‑stage biotechnology company developing highly selective molecular glue degraders (MGDs) for patients living with serious diseases in oncology, autoimmune and inflammatory diseases, and more. Our QuEEN™ (Quantitative and Engineered Elimination of Neosubstrates) discovery engine combines AI‑guided chemistry, diverse chemical libraries, structural biology, and proteomics to rationally design MGDs with unprecedented selectivity.
Seniority Level Mid‑Senior level
Employment Type Full‑time
Job Function Research
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Scientist DMPK
role at
Monte Rosa Therapeutics .
Monte Rosa Therapeutics (MRT) seeks to recruit an experienced, creative and highly talented DMPK and ADME Scientist who is eager to assist in leading the discovery and development effort to grow the drug pipelines, as well as help lead external GxP compliance research efforts. The Scientist will work with MRTx colleagues to participate in all stages of DMPK and ADME assessments, from initial compound screening through to IND and NDA regulatory submissions. Working with Research, Bioanalytical and Clinical Science subject matter experts, the candidate will provide scientific expertise to ensure that clinical candidates with acceptable drug development characteristics are identified and appropriately characterized. The role represents Preclinical Development on Research and Development teams and regularly interfaces with internal and external colleagues to ensure timely and accurate dissemination of DMPK and ADME findings.
Pay Range Base pay range: $125,000.00/yr – $175,000.00/yr
Key Responsibilities
Work closely with the medicinal chemistry team to facilitate the non‑clinical development efforts in troubleshooting and guiding the discovery project team, focusing on optimizing properties for oral administration.
Represent Nonclinical Development to project teams and present our work in the interpretation of ADME experimental data related to in‑vitro and in‑vivo animal PK and biotransformation.
Continually learn in‑vitro ADME and in‑vivo animal PK analysis.
Coordinate outsourced in‑vitro and in‑vivo DMPK studies.
Explore new technologies and capabilities in the discovery DMPK space.
Strong written and oral communication to support internal communication of data, study reports and regulatory documentation.
Ability to work on multiple projects in a matrixed organizational structure.
Assist the Nonclinical Development & Clinical Pharmacology team’s activities across multiple project phases, including lead discovery, lead optimization, and regulatory filings.
Job Requirements
PhD/MS with 3+ years of drug discovery industry experience in Drug Metabolism, Pharmacokinetics, Pharmaceutical Chemistry, Toxicology, or a related scientific discipline.
Effective management of internal and external collaborations/service providers (CROs).
Build relationships with peers and partners outside of Nonclinical Development & Clinical Pharmacology to enable high team performance.
Demonstrates novel, innovative solutions to challenging problems using an extremely high degree of scientific discretion, intuition, and integrity.
Strong collaboration and innovative skills across subject areas representing DMPK as a project team representative within the core team.
Experience in the design, conduct, and interpretation of in‑vitro and in‑vivo ADME and animal PK studies.
Ability to work on site 100% is required.
Interested candidates may forward a CV and Cover Letter in a single PDF via our online portal:
https://www.monterosatx.com/careers/
Monte Rosa Therapeutics is a clinical‑stage biotechnology company developing highly selective molecular glue degraders (MGDs) for patients living with serious diseases in oncology, autoimmune and inflammatory diseases, and more. Our QuEEN™ (Quantitative and Engineered Elimination of Neosubstrates) discovery engine combines AI‑guided chemistry, diverse chemical libraries, structural biology, and proteomics to rationally design MGDs with unprecedented selectivity.
Seniority Level Mid‑Senior level
Employment Type Full‑time
Job Function Research
#J-18808-Ljbffr