Integrated Resources, Inc ( IRI )
Principal Research Scientist-DMPK
Integrated Resources, Inc ( IRI ), Lexington, Massachusetts, United States, 02173
Recruitment Delivery Leader | Expert in Scientific & Clinical Hiring | Performance Mentor | Pharma/Biotech Talent Strategist
Job Summary
The Sr. Scientist will act as a DMPK project representative and provide scientific leadership in the discovery of small molecule drug candidates by integrating DMPK strategy to progress drug discovery projects across several therapeutic areas. This will be achieved by proposing and leading internal and external research efforts to support project goals. The Sr. Scientist will work closely with pharmacology and medicinal chemistry team, lead DMPK efforts to optimize molecules across a variety of therapeutic areas utilizing in vitro, in vivo, and in silico methods and models to generate novel chemical matter with drug-like properties. The Sr. Scientist will collaborate with outsourcing managers to identify and manage CROs with specialized ADME capabilities, and build and maintain relationships with global ADME experts to leverage expertise and harmonize ADME strategy. The individual will be seen across the company and beginning to be viewed externally as a method/subject expert within small molecule DMPK.
Top Skills
Project facing role (3+ years)
ADME or PKPD subject matter expert
Someone with relevant publications/abstracts that speak to metabolism/drug interaction/PKPD modeling.
Purpose The Sr. Scientist will act as a DMPK project representative and provide scientific leadership in the discovery of small molecule drug candidates by integrating DMPK strategy to progress drug discovery projects across several therapeutic areas. This will be achieved by proposing and leading internal and external research efforts to support project goals. The Sr. Scientist will work closely with pharmacology and medicinal chemistry team, lead DMPK efforts to optimize molecules across a variety of therapeutic areas utilizing in vitro, in vivo, and in silico methods and models to generate novel chemical matter with drug-like properties. The Sr. Scientist will collaborate with outsourcing managers to identify and manage CROs with specialized ADME capabilities, and build and maintain relationships with global ADME experts to leverage expertise and harmonize ADME strategy.
Relationships
Reports to the head of the relevant DMPK department
Internal relationships include working closely with technical staff & other members of the scientific leadership team; regular collaborations with members of other research departments at NNRCSI; & frequent interaction with project managers & other colleagues across global R&D. Individual may direct the work of other staff members.
Individual will interact with external research collaborators both academia- & industry-based.
Essential Functions
Function as DMPK project representative for global, cross-functional small molecule project teams to achieve project goals
Provide expert-level guidance to experimental plans and data interpretation with a strong expertise in either ADME/PK/DDI or PK/PD modeling and simulation
Troubleshoot highly complex tasks through independent and team-based efforts
Demonstrate deep subject matter expertise and in-depth experience, as well as creative, independent thinking and solutions for addressing critical scientific questions
Make independent decisions related to day-to-day experimental activities
Work closely with CROs to assume responsibility for DMPK experimental design, implementation, and interpretation
Analyze complex data with high degree of sophistication, connect disparate datasets to reach conclusions, and communicate project updates and experimental results to relevant stakeholders
Ensure proper documentation of all experiments and data
Collaborative teamwork
Communicate regularly with international colleagues
Actively participate in cross-functional teams and meetings to drive project success
Achieve business goals, share learnings, knowledge and skills & promote cross-functional teamwork
Share knowledge & expertise to expand team capabilities and goals
Demonstrate superior cross-cultural understanding to effectively interact with relevant stakeholders in the global organization
Write and review collaborative research manuscripts, project documents, and milestone documents
Complete assignments requiring expert-level knowledge of techniques and practices related to the research area
Represent the organization as NN-subject matter expert by attending and presenting at scientific conferences and global meetings
Qualifications
Bachelor's Degree within subject matter expertise required.
18+ years’ relevant experience required, or a master’s degree with 12+ years’ relevant experience, or a Doctoral degree in with 6+ years’ post-doctoral and/or industry relevant experience can be considered.
Relevant required experience includes: Excellent understanding of ADME principals with knowledge of PK/PD modeling or biotransformation highly desirable.
Preferred experience includes: Prior experience working in a fully or hybrid ADME-outsourced models.
Demonstrates excellent verbal and written communication skills.
Seniority level Director
Employment type Contract
Job function Other
Industries Pharmaceutical Manufacturing, Biotechnology Research, and Research Services
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Top Skills
Project facing role (3+ years)
ADME or PKPD subject matter expert
Someone with relevant publications/abstracts that speak to metabolism/drug interaction/PKPD modeling.
Purpose The Sr. Scientist will act as a DMPK project representative and provide scientific leadership in the discovery of small molecule drug candidates by integrating DMPK strategy to progress drug discovery projects across several therapeutic areas. This will be achieved by proposing and leading internal and external research efforts to support project goals. The Sr. Scientist will work closely with pharmacology and medicinal chemistry team, lead DMPK efforts to optimize molecules across a variety of therapeutic areas utilizing in vitro, in vivo, and in silico methods and models to generate novel chemical matter with drug-like properties. The Sr. Scientist will collaborate with outsourcing managers to identify and manage CROs with specialized ADME capabilities, and build and maintain relationships with global ADME experts to leverage expertise and harmonize ADME strategy.
Relationships
Reports to the head of the relevant DMPK department
Internal relationships include working closely with technical staff & other members of the scientific leadership team; regular collaborations with members of other research departments at NNRCSI; & frequent interaction with project managers & other colleagues across global R&D. Individual may direct the work of other staff members.
Individual will interact with external research collaborators both academia- & industry-based.
Essential Functions
Function as DMPK project representative for global, cross-functional small molecule project teams to achieve project goals
Provide expert-level guidance to experimental plans and data interpretation with a strong expertise in either ADME/PK/DDI or PK/PD modeling and simulation
Troubleshoot highly complex tasks through independent and team-based efforts
Demonstrate deep subject matter expertise and in-depth experience, as well as creative, independent thinking and solutions for addressing critical scientific questions
Make independent decisions related to day-to-day experimental activities
Work closely with CROs to assume responsibility for DMPK experimental design, implementation, and interpretation
Analyze complex data with high degree of sophistication, connect disparate datasets to reach conclusions, and communicate project updates and experimental results to relevant stakeholders
Ensure proper documentation of all experiments and data
Collaborative teamwork
Communicate regularly with international colleagues
Actively participate in cross-functional teams and meetings to drive project success
Achieve business goals, share learnings, knowledge and skills & promote cross-functional teamwork
Share knowledge & expertise to expand team capabilities and goals
Demonstrate superior cross-cultural understanding to effectively interact with relevant stakeholders in the global organization
Write and review collaborative research manuscripts, project documents, and milestone documents
Complete assignments requiring expert-level knowledge of techniques and practices related to the research area
Represent the organization as NN-subject matter expert by attending and presenting at scientific conferences and global meetings
Qualifications
Bachelor's Degree within subject matter expertise required.
18+ years’ relevant experience required, or a master’s degree with 12+ years’ relevant experience, or a Doctoral degree in with 6+ years’ post-doctoral and/or industry relevant experience can be considered.
Relevant required experience includes: Excellent understanding of ADME principals with knowledge of PK/PD modeling or biotransformation highly desirable.
Preferred experience includes: Prior experience working in a fully or hybrid ADME-outsourced models.
Demonstrates excellent verbal and written communication skills.
Seniority level Director
Employment type Contract
Job function Other
Industries Pharmaceutical Manufacturing, Biotechnology Research, and Research Services
#J-18808-Ljbffr