BioSpace
Advisor/Senior Advisor, Purification Development - Bioconjugates
BioSpace, Indianapolis, Indiana, us, 46262
Advisor/Senior Advisor, Purification Development - Bioconjugates
BioSpace is connecting the right talent with Lilly, a global healthcare leader headquartered in Indianapolis, Indiana. Lilly works to discover and bring life‑changing medicines to people around the world, improving understanding and management of disease while supporting communities through philanthropy and volunteerism. This role is focused on advancing purification development for innovative bioconjugates.
Position Summary The Bioproduct Research and Development organization strives to deliver creative medicines to patients by developing and commercialising insulins, monoclonal antibodies, bioconjugates, novel therapeutic proteins, peptides, oligonucleotide therapies and gene therapy systems. This multidisciplinary group collaborates closely with discovery and manufacturing colleagues and provides full access to scientific excellence and engineering capabilities.
As a Purification Development Scientist, you will transform complex biologic candidates—including antibody‑oligonucleotide conjugates, ADCs, PEGylated proteins, viral vectors, recombinant proteins and peptides—through downstream drug substance processes such as purification and filtering. Your work will encompass process development, tech transfer, analytical characterization, and close interaction with CMC, discovery and regulatory teams.
Responsibilities
Identify and develop new purification technologies for complex bioconjugates.
Design optimized downstream drug substance processes with a focus on bioconjugate stability and separation.
Maintain accurate records, interpret data, and provide detailed analysis of experimental execution.
Overcome technical hurdles and support process transfer to GMP manufacturing facilities.
Write technical reports, tech‑transfer documents, and deliver presentations summarizing development activities.
Adapt to new projects and challenges with flexibility.
Troubleshoot issues, identify trends, and propose opportunities to reduce process variability.
Basic Requirements
PhD in Chemical Engineering or related biological separation sciences, OR
MS in Chemistry, Chemical Engineering, or related field with ≥5 years relevant protein purification/process development experience, OR
BS in Chemistry, Chemical Engineering, or related field with ≥8 years relevant experience.
Hands‑on experience with bioconjugate purification.
Additional Preferences
Exceptional attention to detail, experimental design, and record‑keeping.
Effective oral and written communication skills.
Strong laboratory skills and experience with conjugation reactions (PEGylation, ADCs, antibody‑oligonucleotide conjugates).
Experience optimizing conjugation ratios, maintaining conjugate stability, and separating conjugated from unconjugated species.
Understanding of conjugation chemistry and its impact on downstream purification (e.g., HIC, AEX).
Purification development experience with AAV, mRNA, or other gene therapy modalities.
Proficiency in process control and documentation systems (Unicorn, Empower, electronic laboratory notebooks).
Basic analytical skills and advanced problem‑solving abilities.
Physical Demands / Travel The position requires standard laboratory duties and occasional travel to manufacturing facilities. Reasonable accommodations are available for qualified individuals with disabilities.
Work Environment The work is performed in a laboratory setting. Employees may be required to lift up to 50 lbs, stand for extended periods, and work with hazardous chemicals under the safest and compliant conditions.
EEO and Accommodation Statement Lilly is proud to be an equal employment opportunity employer and does not discriminate on the basis of age, race, color, religion, gender identity, sexual orientation, disability, or any other protected status. Reasonable accommodations will be made for qualified individuals with disabilities during the application process.
Compensation Salary: $126,000 – $204,600 (depending on experience and location). Full‑time employees are eligible for a company bonus, 401(k), pension, health, dental, vision, and a comprehensive benefits program.
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Position Summary The Bioproduct Research and Development organization strives to deliver creative medicines to patients by developing and commercialising insulins, monoclonal antibodies, bioconjugates, novel therapeutic proteins, peptides, oligonucleotide therapies and gene therapy systems. This multidisciplinary group collaborates closely with discovery and manufacturing colleagues and provides full access to scientific excellence and engineering capabilities.
As a Purification Development Scientist, you will transform complex biologic candidates—including antibody‑oligonucleotide conjugates, ADCs, PEGylated proteins, viral vectors, recombinant proteins and peptides—through downstream drug substance processes such as purification and filtering. Your work will encompass process development, tech transfer, analytical characterization, and close interaction with CMC, discovery and regulatory teams.
Responsibilities
Identify and develop new purification technologies for complex bioconjugates.
Design optimized downstream drug substance processes with a focus on bioconjugate stability and separation.
Maintain accurate records, interpret data, and provide detailed analysis of experimental execution.
Overcome technical hurdles and support process transfer to GMP manufacturing facilities.
Write technical reports, tech‑transfer documents, and deliver presentations summarizing development activities.
Adapt to new projects and challenges with flexibility.
Troubleshoot issues, identify trends, and propose opportunities to reduce process variability.
Basic Requirements
PhD in Chemical Engineering or related biological separation sciences, OR
MS in Chemistry, Chemical Engineering, or related field with ≥5 years relevant protein purification/process development experience, OR
BS in Chemistry, Chemical Engineering, or related field with ≥8 years relevant experience.
Hands‑on experience with bioconjugate purification.
Additional Preferences
Exceptional attention to detail, experimental design, and record‑keeping.
Effective oral and written communication skills.
Strong laboratory skills and experience with conjugation reactions (PEGylation, ADCs, antibody‑oligonucleotide conjugates).
Experience optimizing conjugation ratios, maintaining conjugate stability, and separating conjugated from unconjugated species.
Understanding of conjugation chemistry and its impact on downstream purification (e.g., HIC, AEX).
Purification development experience with AAV, mRNA, or other gene therapy modalities.
Proficiency in process control and documentation systems (Unicorn, Empower, electronic laboratory notebooks).
Basic analytical skills and advanced problem‑solving abilities.
Physical Demands / Travel The position requires standard laboratory duties and occasional travel to manufacturing facilities. Reasonable accommodations are available for qualified individuals with disabilities.
Work Environment The work is performed in a laboratory setting. Employees may be required to lift up to 50 lbs, stand for extended periods, and work with hazardous chemicals under the safest and compliant conditions.
EEO and Accommodation Statement Lilly is proud to be an equal employment opportunity employer and does not discriminate on the basis of age, race, color, religion, gender identity, sexual orientation, disability, or any other protected status. Reasonable accommodations will be made for qualified individuals with disabilities during the application process.
Compensation Salary: $126,000 – $204,600 (depending on experience and location). Full‑time employees are eligible for a company bonus, 401(k), pension, health, dental, vision, and a comprehensive benefits program.
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