Energy Jobline ZR
Senior Associate Scientist, Viral Vector Cell Line Development in Boston
Energy Jobline ZR, Boston, Massachusetts, us, 02298
Job Overview
Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform––from cells to software––to enable the design and manufacture of next‑therapeutics.
We are seeking a Senior Associate Scientist, Viral Vector to join our Cell Line Development team in Boston, MA. The ideal candidate will have a proven track record performing lentiviral vector stable packaging or producer cell line development in an industry setting. They will be a key contributor to our team, participating in the creation of stable producer cell lines for lentiviral vector therapeutics and research projects to improve our cell line development workflows. They will also work closely with Asimov’s synthetic biology and process development teams.
Responsibilities
Perform lentiviral vector stable producer cell line development processes including transfection, pool, single cell cloning, characterization, and cell banking using state‑of‑the‑art equipment.
Perform assays to assess quantity, potency and infectivity of lentiviral vector preparations.
Support innovation through development of novel workflows and applications.
Support research projects to develop viral vector production methods to enhance product quality attributes such as empty/full ratio, potency and/or cell targeting.
Work effectively as part of a cross‑functional team in support of a Lentiviral CLD platform and in collaboration with Synthetic Biology and Process Development teams.
Design experiments, analyze data, troubleshoot, and maintain detailed records.
Represent LV CLD on project teams, making decisions for cell line development activities and effectively communicating results, progress and plans.
Qualifications
B.S. or M.S. in Biological Engineering, Virology, Cell Biology, Molecular Biology, or a related field.
5+ years of hands‑on experience in biopharma with a minimum of 3 years focused on lentiviral vector producer cell line development in support of GLP or GMP production of cell or gene therapies.
Extensive experience performing viral transductions, flow cytometry, and quantitative gene expression analyses (ddPCR or qPCR).
Experience with downstream purification of lentiviral vectors, T‑cell transduction assay, viral genome engineering, and/or host cell genome engineering related to virus production or producer cell line technologies is highly desired.
Comfortable working with large, multidimensional datasets and applying statistical or computational methods to extract actionable biological or process insights.
Strong written and verbal communication skills required.
Compensation & Benefits The base salary hiring range for this position is expected to be $115,000 to $120,000 annually. The base salary offered may vary based on factors such as the final candidate’s relevant knowledge, skills and experience for the role. Our total rewards package also includes the opportunity for stock options, eligibility for our 401(k) plan, annual career development stipend, medical, dental, vision, life and insurances. Our robust time‑off policy includes flexible time‑off, unlimited sick time, and a career development stipend.
We will talk about compensation in our first conversation and be transparent throughout the process about which level we think is the best match for you in our organization. We’re fueled by a vision to transform biological engineering into a fully‑fledged engineering discipline.
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We are seeking a Senior Associate Scientist, Viral Vector to join our Cell Line Development team in Boston, MA. The ideal candidate will have a proven track record performing lentiviral vector stable packaging or producer cell line development in an industry setting. They will be a key contributor to our team, participating in the creation of stable producer cell lines for lentiviral vector therapeutics and research projects to improve our cell line development workflows. They will also work closely with Asimov’s synthetic biology and process development teams.
Responsibilities
Perform lentiviral vector stable producer cell line development processes including transfection, pool, single cell cloning, characterization, and cell banking using state‑of‑the‑art equipment.
Perform assays to assess quantity, potency and infectivity of lentiviral vector preparations.
Support innovation through development of novel workflows and applications.
Support research projects to develop viral vector production methods to enhance product quality attributes such as empty/full ratio, potency and/or cell targeting.
Work effectively as part of a cross‑functional team in support of a Lentiviral CLD platform and in collaboration with Synthetic Biology and Process Development teams.
Design experiments, analyze data, troubleshoot, and maintain detailed records.
Represent LV CLD on project teams, making decisions for cell line development activities and effectively communicating results, progress and plans.
Qualifications
B.S. or M.S. in Biological Engineering, Virology, Cell Biology, Molecular Biology, or a related field.
5+ years of hands‑on experience in biopharma with a minimum of 3 years focused on lentiviral vector producer cell line development in support of GLP or GMP production of cell or gene therapies.
Extensive experience performing viral transductions, flow cytometry, and quantitative gene expression analyses (ddPCR or qPCR).
Experience with downstream purification of lentiviral vectors, T‑cell transduction assay, viral genome engineering, and/or host cell genome engineering related to virus production or producer cell line technologies is highly desired.
Comfortable working with large, multidimensional datasets and applying statistical or computational methods to extract actionable biological or process insights.
Strong written and verbal communication skills required.
Compensation & Benefits The base salary hiring range for this position is expected to be $115,000 to $120,000 annually. The base salary offered may vary based on factors such as the final candidate’s relevant knowledge, skills and experience for the role. Our total rewards package also includes the opportunity for stock options, eligibility for our 401(k) plan, annual career development stipend, medical, dental, vision, life and insurances. Our robust time‑off policy includes flexible time‑off, unlimited sick time, and a career development stipend.
We will talk about compensation in our first conversation and be transparent throughout the process about which level we think is the best match for you in our organization. We’re fueled by a vision to transform biological engineering into a fully‑fledged engineering discipline.
#J-18808-Ljbffr