GABAeron
Scientist - Neurodegenerative Disease Models
GABAeron, San Francisco, California, United States, 94199
Scientist – Neurodegenerative Disease Models
San Francisco (Mission Bay), on-site, full-time
GABAeron, Inc. is a biopharmaceutical company focusing on the development of therapies using stem cells to treat neurological diseases, such as Alzheimer’s disease. GABAeron takes a novel approach that combines precision medicine (using genetic information for patient stratification) with regenerative medicine (using human iPSC-derived cell products for therapy). The therapeutic programs of GABAeron are specifically designed to replace or protect some of the most vulnerable brain cell populations, restoring and preserving brain functions in patients with genetically defined neurological diseases using human iPSC-derived cell products.
We are seeking an experienced Scientist with deep expertise in neurodegenerative disease research and a strong track record of working with rodent models. The ideal candidate will have hands‑on experience in characterizing both functional and pathological phenotypes and will play a key role in assessing the in vivo efficacy and therapeutic potential of candidate treatments.
This is a lab-based, highly collaborative position focused on leveraging established rodent models to evaluate treatment responses and generate robust, translatable preclinical data. The Scientist will provide leadership in study and execution, employing a range of histological, pathological, and behavioral assays, as well as electrophysiological analyses to evaluate disease phenotypes and assess treatment effects.
Key Responsibilities
Design, execute, and troubleshoot in vivo studies in rodent models of neurodegenerative disease following iPSC‑derived cell transplantation
Perform and refine stereotaxic surgeries related to cell transplantation and electrophysiological studies
Conduct immunohistochemical examination of rodent brains for neuropathological characterization
Plan, execute, and troubleshoot behavioral assays used in rodent models
Utilize protocols for single‑cell RNA analyses, including computational analysis of the data
Manage multiple concurrent projects, ensuring high‑quality, reliable, reproducible, and well‑documented experimental results
Present data effectively in internal meetings and contribute to strategic discussions around preclinical development and IND‑enabling studies.
Qualifications
PhD in Neuroscience, Neuropathology, or a related discipline
5+ years of experience working with rodent models, preferably in neurodegenerative disease research
Demonstrated industry experience in preclinical research studies leading to an IND is strongly preferred
Excellent problem‑solving skills, attention to detail, and ability to adapt in a fast‑paced cross‑functional lab environment
Strong communication, collaboration, and presentation skills
Proficiency with Google Suite, Microsoft applications, and relevant scientific tools
Salary Range : $130,000-$160,000
Please note : Compensation and leveling will be commensurate with experience and expertise and could fall outside of the stated range.
Benefits
Equity
Medical, Dental & Vision Plan Options
Short‑Term and Long‑Term Disability
Group Life Insurance
FSA Plans (medical, dependent daycare, and commuter)
Employee Assistance Program (EAP)
401k Plan
GABAeron provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.
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San Francisco (Mission Bay), on-site, full-time
GABAeron, Inc. is a biopharmaceutical company focusing on the development of therapies using stem cells to treat neurological diseases, such as Alzheimer’s disease. GABAeron takes a novel approach that combines precision medicine (using genetic information for patient stratification) with regenerative medicine (using human iPSC-derived cell products for therapy). The therapeutic programs of GABAeron are specifically designed to replace or protect some of the most vulnerable brain cell populations, restoring and preserving brain functions in patients with genetically defined neurological diseases using human iPSC-derived cell products.
We are seeking an experienced Scientist with deep expertise in neurodegenerative disease research and a strong track record of working with rodent models. The ideal candidate will have hands‑on experience in characterizing both functional and pathological phenotypes and will play a key role in assessing the in vivo efficacy and therapeutic potential of candidate treatments.
This is a lab-based, highly collaborative position focused on leveraging established rodent models to evaluate treatment responses and generate robust, translatable preclinical data. The Scientist will provide leadership in study and execution, employing a range of histological, pathological, and behavioral assays, as well as electrophysiological analyses to evaluate disease phenotypes and assess treatment effects.
Key Responsibilities
Design, execute, and troubleshoot in vivo studies in rodent models of neurodegenerative disease following iPSC‑derived cell transplantation
Perform and refine stereotaxic surgeries related to cell transplantation and electrophysiological studies
Conduct immunohistochemical examination of rodent brains for neuropathological characterization
Plan, execute, and troubleshoot behavioral assays used in rodent models
Utilize protocols for single‑cell RNA analyses, including computational analysis of the data
Manage multiple concurrent projects, ensuring high‑quality, reliable, reproducible, and well‑documented experimental results
Present data effectively in internal meetings and contribute to strategic discussions around preclinical development and IND‑enabling studies.
Qualifications
PhD in Neuroscience, Neuropathology, or a related discipline
5+ years of experience working with rodent models, preferably in neurodegenerative disease research
Demonstrated industry experience in preclinical research studies leading to an IND is strongly preferred
Excellent problem‑solving skills, attention to detail, and ability to adapt in a fast‑paced cross‑functional lab environment
Strong communication, collaboration, and presentation skills
Proficiency with Google Suite, Microsoft applications, and relevant scientific tools
Salary Range : $130,000-$160,000
Please note : Compensation and leveling will be commensurate with experience and expertise and could fall outside of the stated range.
Benefits
Equity
Medical, Dental & Vision Plan Options
Short‑Term and Long‑Term Disability
Group Life Insurance
FSA Plans (medical, dependent daycare, and commuter)
Employee Assistance Program (EAP)
401k Plan
GABAeron provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.
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