BioSpace
Job Overview
Pursuant to Section 20 C.F.R. 656.10, an application for Alien Employment Certification will be filed by Takeda Development Center Americas Inc. for the following job opportunity:
Location Cambridge, MA; Boston, MA
Position Associate Scientist
Job Responsibilities
Lead from the lab to advance novel and differentiated products to the clinic by contributing to discovery projects focused on leveraging V1+ gamma delta T-cells as a cancer treatment.
Independently design, execute, and interpret well‑defined functional in vitro and ex vivo assays to understand the pharmacology and therapeutic mechanism‑of‑action of candidate molecules, and play an active role in subsequent scientific discussions to drive decisions around V1 T‑cells as a cancer therapy.
Propose experiments based on internal results, external partners, and published reports and demonstrate leadership through effective communication of study plans and research results.
Use immune cell characterization and functional assessments, such as high‑parameter flow cytometry, multiplex cytokine measurement, co‑culture cytotoxicity assessment, and other molecular‑ and cell‑based assays and methodologies.
Isolate, culture, and differentiate various immune cell populations from blood and tissue sources.
Analyze, interpret, and present data to partners, and play an active role in subsequent scientific discussions leading to important decisions and program‑ensuring next steps.
Participate in cross‑functional project team meetings to provide key scientific insight.
Multi‑task effectively and prioritize workload.
Work collaboratively with internal cross‑functional teams and act as a V1 subject‑matter expert.
Collaborate with other departments to meet deadlines and generate data crucial for the programs in execution.
Contribute to the writing of relevant research reports to be included in regulatory filings.
Prepare and present comprehensive technical or project reports and formal presentations and posters to full range of internal/external audiences.
Maintain excellent laboratory notebook documentation and keep in compliance with Takeda policies.
Up to 20% remote work allowed.
Requirements
Master’s degree in Biology, Biosciences, or related field plus 18 months of related experience.
Prior experience must include:
Isolate, culture and expand V1 gamma delta T cells from blood, healthy tissue and tumor sources;
Design and execute in vitro/ex vivo assays of V1 gamma delta T cell function, including cytotoxicity, survival, and proliferation;
Analyze experimental data and determine the relevance of results based on background knowledge of V1 gamma delta T cell biology;
Contribute to evaluation of novel immunotherapy products based on V1 gamma delta T cell biology;
Design and optimize RNA‑FISH PrimeFlow Cytometric Assays for the identification of Vδ1 γδ T cells.
Compensation & Remote Work Full time. $99,500 - $170,600 per year. Up to 20% remote work allowed.
How to Apply Qualified applicants can apply at
https://jobs.takeda.com . Please reference job #R0166130.
EEO Statement EOE
#J-18808-Ljbffr
Location Cambridge, MA; Boston, MA
Position Associate Scientist
Job Responsibilities
Lead from the lab to advance novel and differentiated products to the clinic by contributing to discovery projects focused on leveraging V1+ gamma delta T-cells as a cancer treatment.
Independently design, execute, and interpret well‑defined functional in vitro and ex vivo assays to understand the pharmacology and therapeutic mechanism‑of‑action of candidate molecules, and play an active role in subsequent scientific discussions to drive decisions around V1 T‑cells as a cancer therapy.
Propose experiments based on internal results, external partners, and published reports and demonstrate leadership through effective communication of study plans and research results.
Use immune cell characterization and functional assessments, such as high‑parameter flow cytometry, multiplex cytokine measurement, co‑culture cytotoxicity assessment, and other molecular‑ and cell‑based assays and methodologies.
Isolate, culture, and differentiate various immune cell populations from blood and tissue sources.
Analyze, interpret, and present data to partners, and play an active role in subsequent scientific discussions leading to important decisions and program‑ensuring next steps.
Participate in cross‑functional project team meetings to provide key scientific insight.
Multi‑task effectively and prioritize workload.
Work collaboratively with internal cross‑functional teams and act as a V1 subject‑matter expert.
Collaborate with other departments to meet deadlines and generate data crucial for the programs in execution.
Contribute to the writing of relevant research reports to be included in regulatory filings.
Prepare and present comprehensive technical or project reports and formal presentations and posters to full range of internal/external audiences.
Maintain excellent laboratory notebook documentation and keep in compliance with Takeda policies.
Up to 20% remote work allowed.
Requirements
Master’s degree in Biology, Biosciences, or related field plus 18 months of related experience.
Prior experience must include:
Isolate, culture and expand V1 gamma delta T cells from blood, healthy tissue and tumor sources;
Design and execute in vitro/ex vivo assays of V1 gamma delta T cell function, including cytotoxicity, survival, and proliferation;
Analyze experimental data and determine the relevance of results based on background knowledge of V1 gamma delta T cell biology;
Contribute to evaluation of novel immunotherapy products based on V1 gamma delta T cell biology;
Design and optimize RNA‑FISH PrimeFlow Cytometric Assays for the identification of Vδ1 γδ T cells.
Compensation & Remote Work Full time. $99,500 - $170,600 per year. Up to 20% remote work allowed.
How to Apply Qualified applicants can apply at
https://jobs.takeda.com . Please reference job #R0166130.
EEO Statement EOE
#J-18808-Ljbffr