Foresite Labs
Sr Staff Engineer, R&D, Mechanical Engineer
Foresite Labs, San Diego, California, United States, 92189
Sr Staff Engineer, R&D, Mechanical Engineer
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Sr Staff Engineer, R&D, Mechanical Engineer
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Foresite Labs 1 day ago Be among the first 25 applicants Join to apply for the
Sr Staff Engineer, R&D, Mechanical Engineer
role at
Foresite Labs Get AI-powered advice on this job and more exclusive features. We are a venture-backed, stealth-stage biotechnology company based in San Diego, focused on developing novel technologies that will redefine how disease is detected, characterized, and managed with a novel approach to clinical genomics. Our mission is to fundamentally transform healthcare through a convergence of innovation across multiple scientific disciplines. Founded by industry veterans with decades of experience in life sciences tools and diagnostics, our leadership team brings a proven track record of translating scientific insight into successful commercial products. Our investors include some of the most respected names in healthcare and deep tech. In this role as a Sr Staff Mechanical Engineer, you’ll drive the design of an innovative automation system for precision handling and processing of custom parts, with modules for transfer & positioning, thermal control, and controlled fluid storage and dispense. The role will exercise expertise in precision machine design, electro-mechanical control systems, and metrology development. You will be a key member of the core engineering team responsible for defining and delivering our flagship platform. Responsibilities
Define requirements, specifications, tolerance stacks, and error budgets for mechanical subsystems, and conduct trade studies to optimize the architecture for performance, manufacturability, cost, and reliability. Own the mechanical system architecture for part processing and precision fluid management modules. Design, develop, and validate complex, high‑performance electromechanical assemblies for part transfer, precision positioning, thermal control, fluid storage and precision dispense, and controlled environmental systems. Develop metrology solutions for system monitoring, including machine vision for position and alignment measurement, optical or imaging‑based fluid contamination detection, and dynamic spatial temperature measurement and calibration. Select and integrate key components such as motors, bearings, encoders, drives, pneumatics, pumps, valves, sensors, seals, heaters, and thermoelectrics. Collaborate closely with systems, electrical, and software engineers to align mechanical and control architectures. Partner with assay scientists to ensure mechanical designs meet biological and chemical requirements. Work with operations, manufacturing, and supply chain to ensure scalability, cost‑efficiency, and high‑quality builds. Lead prototype builds and iterative design improvements based on empirical test results, and define and execute mechanical and system‑level verification and validation plans. Analyze performance data and reliability metrics to drive continuous improvement. Minimum Qualifications
B.S. or M.S. in Mechanical Engineering or related field. 10–15+ years of experience designing precision electromechanical or fluidic systems for production instruments or automation platforms. Proven ownership of complex systems from concept through product launch. Expert in 3D CAD (SolidWorks) with strong proficiency in GD&T and detailed mechanical drawings. Deep expertise in machine design and precision motion systems. Strong analytical and modeling skills – mechanical, thermal, and system‑level. Preferred Qualifications
Experience in bioinstrumentation, analytical devices, or medical instruments. Working knowledge of embedded controls, sensors, and mechatronic integration. Experience mentoring other engineers and influencing design culture. Seniority Level
Mid‑Senior level Employment Type
Full‑time Job Function
Engineering and Information Technology Industries
Biotechnology Referrals increase your chances of interviewing at Foresite Labs by 2x Get notified about new Staff Research Development Engineer jobs in
San Diego, CA .
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Join to apply for the
Sr Staff Engineer, R&D, Mechanical Engineer
role at
Foresite Labs 1 day ago Be among the first 25 applicants Join to apply for the
Sr Staff Engineer, R&D, Mechanical Engineer
role at
Foresite Labs Get AI-powered advice on this job and more exclusive features. We are a venture-backed, stealth-stage biotechnology company based in San Diego, focused on developing novel technologies that will redefine how disease is detected, characterized, and managed with a novel approach to clinical genomics. Our mission is to fundamentally transform healthcare through a convergence of innovation across multiple scientific disciplines. Founded by industry veterans with decades of experience in life sciences tools and diagnostics, our leadership team brings a proven track record of translating scientific insight into successful commercial products. Our investors include some of the most respected names in healthcare and deep tech. In this role as a Sr Staff Mechanical Engineer, you’ll drive the design of an innovative automation system for precision handling and processing of custom parts, with modules for transfer & positioning, thermal control, and controlled fluid storage and dispense. The role will exercise expertise in precision machine design, electro-mechanical control systems, and metrology development. You will be a key member of the core engineering team responsible for defining and delivering our flagship platform. Responsibilities
Define requirements, specifications, tolerance stacks, and error budgets for mechanical subsystems, and conduct trade studies to optimize the architecture for performance, manufacturability, cost, and reliability. Own the mechanical system architecture for part processing and precision fluid management modules. Design, develop, and validate complex, high‑performance electromechanical assemblies for part transfer, precision positioning, thermal control, fluid storage and precision dispense, and controlled environmental systems. Develop metrology solutions for system monitoring, including machine vision for position and alignment measurement, optical or imaging‑based fluid contamination detection, and dynamic spatial temperature measurement and calibration. Select and integrate key components such as motors, bearings, encoders, drives, pneumatics, pumps, valves, sensors, seals, heaters, and thermoelectrics. Collaborate closely with systems, electrical, and software engineers to align mechanical and control architectures. Partner with assay scientists to ensure mechanical designs meet biological and chemical requirements. Work with operations, manufacturing, and supply chain to ensure scalability, cost‑efficiency, and high‑quality builds. Lead prototype builds and iterative design improvements based on empirical test results, and define and execute mechanical and system‑level verification and validation plans. Analyze performance data and reliability metrics to drive continuous improvement. Minimum Qualifications
B.S. or M.S. in Mechanical Engineering or related field. 10–15+ years of experience designing precision electromechanical or fluidic systems for production instruments or automation platforms. Proven ownership of complex systems from concept through product launch. Expert in 3D CAD (SolidWorks) with strong proficiency in GD&T and detailed mechanical drawings. Deep expertise in machine design and precision motion systems. Strong analytical and modeling skills – mechanical, thermal, and system‑level. Preferred Qualifications
Experience in bioinstrumentation, analytical devices, or medical instruments. Working knowledge of embedded controls, sensors, and mechatronic integration. Experience mentoring other engineers and influencing design culture. Seniority Level
Mid‑Senior level Employment Type
Full‑time Job Function
Engineering and Information Technology Industries
Biotechnology Referrals increase your chances of interviewing at Foresite Labs by 2x Get notified about new Staff Research Development Engineer jobs in
San Diego, CA .
#J-18808-Ljbffr